Urinary neutrophil gelatinase-associated lipocalin and plasma IL-6 in discontinuation of continuous venovenous hemodiafiltration for severe acute kidney injury: a multicenter prospective observational study

Annals of Intensive Care

Table 2 Baseline characteristics at CVVHDF discontinuation (CVVHDF survivors, n = 105)

Characteristics	Success group (n = 70)	Failure group (n = 35)	P value
Age, year	65 [49, 74]	68 [53, 76]	0.25
Men, n (%)	46 (65.7)	25 (71.4)	0.35
CVVHDF duration, hour	63 [40, 148]	140 [62, 354]	< 0.01*
Effluent flow rate of CVVHDF/BW, ml/h/kg	22.4 [18.1, 28.8]	19.4 [14.2, 24.5]	0.07
Total fluid balance during CVVHDF, ml	− 1179 [− 4499, 1661]	− 1066 [− 4169, 4402]	0.72
Urine amount, ml/day	1730 [877, 2940]	360 [74, 930]	< 0.01*
PaO₂/FIO₂ ratio	320 [213, 435]	317 [268, 435]	0.42
SOFA score	8 [5, 10]	8 [5, 11]	0.76
Mean arterial pressure, mmHg	83 [72, 95]	82 [74, 95]	0.96
Heart rate, /minute	89 [76, 100]	83 [70, 100]	0.34
Use of ventilator, n (%)	33 (47.1)	14 (40.0)	0.49
Use of vasopressor(s), n (%)	36 (51.4)	8 (22.9)	< 0.01*
Use of diuretic(s), n (%)	40 (57.1)	12 (34.3)	0.03*
Laboratory data
White blood cell count,/µl	10850 [8375, 16000]	10800 [6000, 16000]	0.86
Hemoglobin, g/dl	9.2 [8.3, 10.8]	8.6 [7.9, 9.5]	0.04*
Platelet count, × 10⁴/dl	9.7 [5.2, 13.9]	14.6 [6.4, 17.3]	0.03*
Blood urea nitrogen, mg/dl	21.8 [13.0, 34.5]	39.5 [25.7, 53.1]	< 0.01*
Serum creatinine, mg/dl	1.01 [0.76, 1.79]	2.11 [1.36, 3.41]	< 0.01*
Serum potassium, mEq/l	4.2 [3.8, 4.5]	4.3 [3.7, 4.6]	0.79
Total bilirubin, mg/dl	1.4 [0.8, 4.5]	2.5 [0.7, 5.2]	0.60
C-reactive protein, mg/dl	9.0 [3.3, 18.3]	7.9 [5.4, 15.3]	0.72
Arterial pH	7.43 [7.39, 7.45]	7.43 [7.40, 7.46]	0.35
Lactate, mmol/l	1.0 [0.8, 1.5]	1.3 [0.8, 1.6]	0.60

Data are displayed as n (%) or median [interquartile range]
CVVHDF continuous venovenous hemodiafiltration; SOFA Sequential Organ Failure Assessment
^*p < 0.0