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  1. Titration of the continuous distending pressure during a staircase incremental–decremental pressure lung volume optimization maneuver in children on high-frequency oscillatory ventilation is traditionally driv...

    Authors: Pauline de Jager, Johannes G. M. Burgerhof, Alette A. Koopman, Dick G. Markhorst and Martin C. J. Kneyber
    Citation: Annals of Intensive Care 2020 10:153
  2. Assessment and maintenance of end-organ perfusion are key to resuscitation in critical illness, although there are limited direct methods or proxy measures to assess cerebral perfusion. Novel non-invasive meth...

    Authors: E. Courtie, T. Veenith, A. Logan, A. K. Denniston and R. J. Blanch
    Citation: Annals of Intensive Care 2020 10:152
  3. In COVID-19 patients with severe acute respiratory distress syndrome (ARDS), the relatively preserved respiratory system compliance despite severe hypoxemia, with specific pulmonary vascular dysfunction, sugge...

    Authors: François Bagate, Samuel Tuffet, Paul Masi, François Perier, Keyvan Razazi, Nicolas de Prost, Guillaume Carteaux, Didier Payen and Armand Mekontso Dessap
    Citation: Annals of Intensive Care 2020 10:151
  4. Persistent hyperlactatemia has been considered as a signal of tissue hypoperfusion in septic shock patients, but multiple non-hypoperfusion-related pathogenic mechanisms could be involved. Therefore, pursuing ...

    Authors: Ricardo Castro, Eduardo Kattan, Giorgio Ferri, Ronald Pairumani, Emilio Daniel Valenzuela, Leyla Alegría, Vanessa Oviedo, Nicolás Pavez, Dagoberto Soto, Magdalena Vera, César Santis, Brusela Astudillo, María Alicia Cid, Sebastian Bravo, Gustavo Ospina-Tascón, Jan Bakker…
    Citation: Annals of Intensive Care 2020 10:150
  5. Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation ...

    Authors: Elsa Manquat, Matthieu Le Dorze, Gauthier Pean De Ponfilly, Hanaa Benmansour, Rishma Amarsy, Emmanuelle Cambau, Benjamin Soyer, Benjamin Glenn Chousterman and Hervé Jacquier
    Citation: Annals of Intensive Care 2020 10:149

    The Correction to this article has been published in Annals of Intensive Care 2021 11:84

  6. Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels
    Citation: Annals of Intensive Care 2020 10:148

    The original article was published in Annals of Intensive Care 2020 10:36

  7. Authors: Elisa Damiani, Andrea Carsetti, Erika Casarotta, Roberta Domizi, Claudia Scorcella, Erica Adrario and Abele Donati
    Citation: Annals of Intensive Care 2020 10:147

    The original article was published in Annals of Intensive Care 2020 10:140

    The original article was published in Annals of Intensive Care 2020 10:95

  8. The impact of neutropenia in critically ill immunocompromised patients admitted in a context of acute respiratory failure (ARF) remains uncertain. The primary objective was to assess the prognostic impact of n...

    Authors: Djamel Mokart, Michael Darmon, Peter Schellongowski, Peter Pickkers, Marcio Soares, Jordi Rello, Philippe R. Bauer, Andry van de Louw, Virginie Lemiale, Fabio Silvio Taccone, Ignacio Martin-Loeches, Jorge Salluh, Katerina Rusinova, Sangeeta Mehta, Massimo Antonelli, Achille Kouatchet…
    Citation: Annals of Intensive Care 2020 10:146
  9. Sepsis is one of the leading causes of death worldwide. The associated incidence, mortality and trends do not differ greatly between documented reports. The purpose of this study was to provide an in-depth des...

    Authors: Claire Dupuis, Lila Bouadma, Stéphane Ruckly, Anne Perozziello, Damien Van-Gysel, Arthur Mageau, Bruno Mourvillier, Etienne de Montmollin, Sébastien Bailly, Gregory Papin, Fabrice Sinnah, Camille Vinclair, Sonia Abid, Romain Sonneville and Jean-François Timsit
    Citation: Annals of Intensive Care 2020 10:145
  10. Patient–ventilator asynchrony is common in mechanically ventilated patients and may be related to adverse outcomes. Few studies have reported the occurrence of asynchrony in brain-injured patients. We aimed to...

    Authors: Xu-Ying Luo, Xuan He, Yi-Min Zhou, Yu-Mei Wang, Jing-Ran Chen, Guang-Qiang Chen, Hong-Liang Li, Yan-Lin Yang, Linlin Zhang and Jian-Xin Zhou
    Citation: Annals of Intensive Care 2020 10:144
  11. Immune checkpoint inhibitors have reshaped the standard of care in oncology. However, they have been associated with potentially life-threatening immune-related adverse events. With the growing indications of ...

    Authors: Adrien Joseph, Audrey Simonaggio, Annabelle Stoclin, Antoine Vieillard-Baron, Guillaume Geri, Stéphane Oudard, Jean-Marie Michot, Olivier Lambotte, Elie Azoulay and Virginie Lemiale
    Citation: Annals of Intensive Care 2020 10:143
  12. Despite advances in the management of bloodstream infections (BSI) caused by Candida spp., the mortality still remains high in critically ill patients. The worldwide epidemiology of yeast-related BSI is subject t...

    Authors: Maria Schroeder, Theresa Weber, Timme Denker, Sarah Winterland, Dominic Wichmann, Holger Rohde, Ann-Kathrin Ozga, Marlene Fischer and Stefan Kluge
    Citation: Annals of Intensive Care 2020 10:142
  13. The average length of stay (LOS) in the intensive care unit (ICU_ALOS) is a helpful parameter summarizing critical bed occupancy. During the outbreak of a novel virus, estimating early a reliable ICU_ALOS esti...

    Authors: Nathanael Lapidus, Xianlong Zhou, Fabrice Carrat, Bruno Riou, Yan Zhao and Gilles Hejblum
    Citation: Annals of Intensive Care 2020 10:135
  14. Authors: Patrick M. Honore, Leonel Barreto Gutierrez, Luc Kugener, Sebastien Redant, Rachid Attou, Andrea Gallerani and David De Bels
    Citation: Annals of Intensive Care 2020 10:139

    The original article was published in Annals of Intensive Care 2020 10:94

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2020 10:141

  15. Persistent swallowing disorders (SD) are non-pulmonary complications of mechanical ventilation (MV). However, there are few clinical studies on persistent SD in critically ill patients undergoing tracheal intu...

    Authors: G. Beduneau, V. Souday, J. C. Richard, J. F. Hamel, D. Carpentier, J. M. Chretien, P. Bouchetemble, L. Laccoureye, A. Astier, V. Tanguy, A. Mercat, F. Beloncle and F. Tamion
    Citation: Annals of Intensive Care 2020 10:138
  16. Data on outcome of critically ill children with cirrhosis are scarce. We aimed to evaluate the prognostic accuracy of sequential organs scoring systems in children with cirrhosis admitted to Paediatric Intensi...

    Authors: Caroline Claude, Akash Deep, Martin Kneyber, Salman Siddiqui, Sylvain Renolleau, Luc Morin, Emmanuel Jacquemin, Jean-Paul Teglas, Vincent Gajdos, Pierre Tissières and Philippe Durand
    Citation: Annals of Intensive Care 2020 10:137
  17. Early treatment is advocated in the management of patients with suspected sepsis in the emergency department (ED). We sought to understand the association between the ED treatments and outcome in patients admi...

    Authors: Narani Sivayoham, Lesley A. Blake, Shafi E. Tharimoopantavida, Saad Chughtai, Adil N. Hussain and Andrew Rhodes
    Citation: Annals of Intensive Care 2020 10:136
  18. A Covid-19 outbreak developed in Lombardy, Veneto and Emilia-Romagna (Italy) at the end of February 2020. Fear of an imminent saturation of available ICU beds generated the notion that rationing of intensive c...

    Authors: Tommaso Tonetti, Giacomo Grasselli, Alberto Zanella, Giacinto Pizzilli, Roberto Fumagalli, Simone Piva, Luca Lorini, Giorgio Iotti, Giuseppe Foti, Sergio Colombo, Luigi Vivona, Sandra Rossi, Massimo Girardis, Vanni Agnoletti, Anselmo Campagna, Giovanni Gordini…
    Citation: Annals of Intensive Care 2020 10:133
  19. Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. Despite treatment being in line with current guidelines, mortality remains high in those with septic shock. I...

    Authors: Axel Nierhaus, Giorgio Berlot, Detlef Kindgen-Milles, Eckhard Müller and Massimo Girardis
    Citation: Annals of Intensive Care 2020 10:132
  20. Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS).

    Authors: David Grimaldi, Nadia Aissaoui, Gauthier Blonz, Giuseppe Carbutti, Romain Courcelle, Stephane Gaudry, Aurelie Gaultier, Alain D’hondt, Julien Higny, Geoffrey Horlait, Sami Hraiech, Laurent Lefebvre, Francois Lejeune, Andre Ly, Michael Piagnerelli, Bertrand Sauneuf…
    Citation: Annals of Intensive Care 2020 10:131
  21. Intra-abdominal hypertension is frequently present in critically ill patients and is an independent predictor for mortality. Risk factors for intra-abdominal hypertension and abdominal compartment syndrome hav...

    Authors: Marije Smit, Bart Koopman, Willem Dieperink, Jan B. F. Hulscher, H. Sijbrand Hofker, Matijs van Meurs and Jan G. Zijlstra
    Citation: Annals of Intensive Care 2020 10:130
  22. Data on respiratory mechanics of COVID-19 ARDS patients are scarce. Respiratory mechanics and response to positive expiratory pressure (PEEP) may be different in obese and non-obese patients.

    Authors: Mehdi Mezidi, Florence Daviet, Paul Chabert, Sami Hraiech, Laurent Bitker, Jean-Marie Forel, Hodane Yonis, Ines Gragueb, Francois Dhelft, Laurent Papazian, Jean-Christophe Richard and Christophe Guervilly
    Citation: Annals of Intensive Care 2020 10:129
  23. About 30% of patients with Guillain-Barré syndrome become ventilator dependent, of whom roughly 75% develop pneumonia. This trial aimed at assessing the impact of early mechanical ventilation (EMV) on pneumoni...

    Authors: Marie-Anne Melone, Nicholas Heming, Paris Meng, Dominique Mompoint, Jerôme Aboab, Bernard Clair, Jerôme Salomon, Tarek Sharshar, David Orlikowski, Sylvie Chevret and Djillali Annane
    Citation: Annals of Intensive Care 2020 10:128
  24. Extracorporeal CO2 removal (ECCO2R) could be a valuable additional modality for invasive mechanical ventilation (IMV) in COPD patients suffering from severe acute exacerbation (AE). We aimed to evaluate in such p...

    Authors: J.-L. Diehl, L. Piquilloud, D. Vimpere, N. Aissaoui, E. Guerot, J. L. Augy, M. Pierrot, D. Hourton, A. Arnoux, C. Richard, J. Mancebo and A. Mercat
    Citation: Annals of Intensive Care 2020 10:126
  25. Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non...

    Authors: Virginie Montiel, Arnaud Robert, Annie Robert, Anas Nabaoui, Tourneux Marie, Natalia Morales Mestre, Maerckx Guillaume, Pierre-François Laterre and Xavier Wittebole
    Citation: Annals of Intensive Care 2020 10:125
  26. Preliminary reports have described significant procoagulant events in patients with coronavirus disease-2019 (COVID-19), including life-threatening pulmonary embolism (PE).

    Authors: Yasser Sakr, Manuela Giovini, Marc Leone, Giacinto Pizzilli, Andreas Kortgen, Michael Bauer, Tommaso Tonetti, Gary Duclos, Laurent Zieleskiewicz, Samuel Buschbeck, V. Marco Ranieri and Elio Antonucci
    Citation: Annals of Intensive Care 2020 10:124
  27. Acute respiratory failure is the main reason for admission to the intensive care unit (ICU) in HIV-infected adults. There is little data about the epidemiology of respiratory viruses in this population.

    Authors: Alexandre Elabbadi, Jérémie Pichon, Benoit Visseaux, Aurélie Schnuriger, Lila Bouadma, Quentin Philippot, Juliette Patrier, Vincent Labbé, Stéphane Ruckly, Muriel Fartoukh, Jean-François Timsit and Guillaume Voiriot
    Citation: Annals of Intensive Care 2020 10:123
  28. Multiple screening Duplex ultrasound scans (DUS) are performed in trauma patients at high risk of deep vein thrombosis (DVT) in the intensive care unit (ICU). Intensive care physician performed compression ult...

    Authors: Lloyd Roberts, Tom Rozen, Deirdre Murphy, Adam Lawler, Mark Fitzgerald, Harry Gibbs, Kyle Brooks, Joshua F. Ihle, Tim Leong, Judit Orosz, Eldho Paul and Vinodh Bhagyalakshmi Nanjayya
    Citation: Annals of Intensive Care 2020 10:122
  29. Persistent hypotension is a frequent complication after cardiac surgery with cardiopulmonary bypass (CPB). Midodrine, an orally administered alpha agonist, could potentially reduce intravenous vasopressor use ...

    Authors: Jan-Alexis Tremblay, Philippe Laramée, Yoan Lamarche, André Denault, William Beaubien-Souligny, Anne-Julie Frenette, Loay Kontar, Karim Serri and Emmanuel Charbonney
    Citation: Annals of Intensive Care 2020 10:121
  30. Although mechanical ventilation is a lifesaving treatment, abundant evidence indicates that its prolonged use (1 week or more) promotes respiratory muscle weakness due to both contractile dysfunction and atrop...

    Authors: Paolo Formenti, Michele Umbrello, Martin Dres and Davide Chiumello
    Citation: Annals of Intensive Care 2020 10:120
  31. Data on the prevalence of bacterial and viral co-infections among patients admitted to the ICU for acute respiratory failure related to SARS-CoV-2 pneumonia are lacking. We aimed to assess the rate of bacteria...

    Authors: Damien Contou, Aurore Claudinon, Olivier Pajot, Maïté Micaëlo, Pascale Longuet Flandre, Marie Dubert, Radj Cally, Elsa Logre, Megan Fraissé, Hervé Mentec and Gaëtan Plantefève
    Citation: Annals of Intensive Care 2020 10:119
  32. The French Society of Intensive Care Medicine (SRLF), jointly with the French-Speaking Group of Paediatric Emergency Rooms and Intensive Care Units (GFRUP) and the French-Speaking Association of Paediatric Sur...

    Authors: Jean-François Timsit, Julien Baleine, Louis Bernard, Silvia Calvino-Gunther, Michael Darmon, Jean Dellamonica, Eric Desruennes, Marc Leone, Alain Lepape, Olivier Leroy, Jean-Christophe Lucet, Zied Merchaoui, Olivier Mimoz, Benoit Misset, Jean-Jacques Parienti, Jean-Pierre Quenot…
    Citation: Annals of Intensive Care 2020 10:118
  33. Acute Kidney Injury (AKI) is a frequent complication of severe SARS-CoV-2 infection. Multiple mechanisms are involved in COVID-19-associated AKI, from direct viral infection and secondary inflammation to compl...

    Authors: Adrien Joseph, Lara Zafrani, Asma Mabrouki, Elie Azoulay and Michael Darmon
    Citation: Annals of Intensive Care 2020 10:117
  34. Nonintubated chest trauma patients with fractured ribs admitted to the intensive care unit (ICU) are at risk for complications and may require invasive ventilation at some point. Effective pain control is esse...

    Authors: Konstantinos Bachoumas, Albrice Levrat, Aurélie Le Thuaut, Stéphane Rouleau, Samuel Groyer, Hervé Dupont, Paul Rooze, Nathanael Eisenmann, Timothée Trampont, Julien Bohé, Benjamin Rieu, Jean-Charles Chakarian, Aurélie Godard, Laura Frederici, Stephanie Gélinotte, Aurélie Joret…
    Citation: Annals of Intensive Care 2020 10:116
  35. Critical illness has detrimental effects on the diaphragm, but the impact of critical illness on other major muscles of the respiratory pump has been largely neglected. This study aimed to determine the impact...

    Authors: Marloes M. IJland, Joris Lemson, Johannes G. van der Hoeven and Leo M. A. Heunks
    Citation: Annals of Intensive Care 2020 10:115
  36. Capillary refill time (CRT) may improve more rapidly than lactate in response to increments in systemic flow. Therefore, it can be assessed more frequently during septic shock (SS) resuscitation. Hyperlactatem...

    Authors: Eduardo Kattan, Glenn Hernández, Gustavo Ospina-Tascón, Emilio Daniel Valenzuela, Jan Bakker and Ricardo Castro
    Citation: Annals of Intensive Care 2020 10:114
  37. The objective of this study was to evaluate the ability of endothelial biomarkers to early predict clinical deterioration of patients admitted to the emergency department (ED) with a suspected sepsis. This was...

    Authors: Thomas Lafon, Marie-Angélique Cazalis, Christine Vallejo, Karim Tazarourte, Sophie Blein, Alexandre Pachot, Pierre-François Laterre, Said Laribi and Bruno François
    Citation: Annals of Intensive Care 2020 10:113
  38. Gasping during cardiac arrest is associated with favourable neurological outcomes for out-of-hospital cardiac arrest. Moreover, while extracorporeal cardiopulmonary resuscitation (ECPR) performed for refractor...

    Authors: Naofumi Bunya, Hirofumi Ohnishi, Kenshiro Wada, Ryuichiro Kakizaki, Takehiko Kasai, Nobutaka Nagano, Nobuaki Kokubu, Kei Miyata, Shuji Uemura, Keisuke Harada and Eichi Narimatsu
    Citation: Annals of Intensive Care 2020 10:112
  39. Red blood cell (RBC) transfusions are associated with risks including immunological reactions and volume overload. Current guidelines suggest a restrictive transfusion strategy in most patients with sepsis but...

    Authors: Caroline Ulfsdotter Nilsson, Peter Bentzer, Linnéa E. Andersson, Sofia A. Björkman, Fredrik P. Hanssson and Thomas Kander
    Citation: Annals of Intensive Care 2020 10:111
  40. The COVID-19 pandemic has resulted in an unprecedented healthcare crisis with a high prevalence of psychological distress in healthcare providers. We sought to document the prevalence of burnout syndrome among...

    Authors: Elie Azoulay, Jan De Waele, Ricard Ferrer, Thomas Staudinger, Marta Borkowska, Pedro Povoa, Katerina Iliopoulou, Antonio Artigas, Stefan J. Schaller, Manu Shankar Hari, Mariangela Pellegrini, Michael Darmon, Jozef Kesecioglu and Maurizio Cecconi
    Citation: Annals of Intensive Care 2020 10:110
  41. Hypoxemia is the main feature of COVID-19-related acute respiratory distress syndrome (C-ARDS), but its underlying mechanisms are debated, especially in patients with low respiratory system elastance (Ers). We...

    Authors: Paul Masi, François Bagate, Thomas d’Humières, Lara Al-Assaad, Laure Abou Chakra, Genevieve Derumeaux and Armand Mekontso Dessap
    Citation: Annals of Intensive Care 2020 10:108
  42. Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs witho...

    Authors: Daniel E. Hurtado, Benjamín Erranz, Felipe Lillo, Mauricio Sarabia-Vallejos, Pablo Iturrieta, Felipe Morales, Katherine Blaha, Tania Medina, Franco Diaz and Pablo Cruces
    Citation: Annals of Intensive Care 2020 10:107
  43. In critically ill patients, tigecycline (TGC) remains an important therapeutic option due to its efficacy against multiresistant Gram-positive and Gram-negative bacteria. TGC is metabolized and eliminated pred...

    Authors: Rawan Alraish, Sebastian G. Wicha, Otto R. Frey, Anka C. Roehr, Johann Pratschke, Martin Stockmann, Tilo Wuensch and Magnus Kaffarnik
    Citation: Annals of Intensive Care 2020 10:106

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