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  1. Content type: Review

    The pharmacokinetics of beta-lactam antibiotics in intensive care patients may be profoundly altered due to the dynamic, unpredictable pathophysiological changes that occur in critical illness. For many drugs,...

    Authors: Fekade Bruck Sime, Michael S Roberts, Sandra L Peake, Jeffrey Lipman and Jason A Roberts

    Citation: Annals of Intensive Care 2012 2:35

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  2. Content type: Research

    Work and family are the two domains from which most adults develop satisfaction in life. They also are responsible for stressful experiences. There is a perception in the community that work is increasingly th...

    Authors: Nathalie Embriaco, Sami Hraiech, Elie Azoulay, Karine Baumstarck-Barrau, Jean-Marie Forel, Nancy Kentish-Barnes, Frédéric Pochard, Anderson Loundou, Antoine Roch and Laurent Papazian

    Citation: Annals of Intensive Care 2012 2:34

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  3. Content type: Research

    Acute respiratory distress syndrome (ARDS) is a potentially fatal disease with high mortality. Our aim was to summarize the current evidence for use of neuromuscular blocking agents (NMBA) in the early phase o...

    Authors: Ary Serpa Neto, Victor Galvão Moura Pereira, Daniel Crepaldi Espósito, Maria Cecília Toledo Damasceno and Marcus J Schultz

    Citation: Annals of Intensive Care 2012 2:33

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  4. Content type: Review

    Vasculitis is characterized by the infiltration of vessel walls by inflammatory leukocytes with reactive damage and subsequent loss of vessel integrity. The clinical course of systemic vasculitis may be punctu...

    Authors: Mohamad Zaidan, Eric Mariotte, Lionel Galicier, Bertrand Arnulf, Véronique Meignin, Jérôme Vérine, Alfred Mahr and Élie Azoulay

    Citation: Annals of Intensive Care 2012 2:31

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  5. Content type: Research

    Even with an adequate pain assessment, critically ill patients under sedation experience pain during procedures in the intensive care unit (ICU). We evaluated the effects of adjunctive administration of Remife...

    Authors: Hervé Quintard, Isabelle Pavlakovic, Jean Mantz and Carole Ichai

    Citation: Annals of Intensive Care 2012 2:29

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  6. Content type: Research

    Patients in intensive care units receive many drugs simultaneously but through limited venous accesses. Several intravenous therapies have to be administered through the same catheter, thus increasing the risk...

    Authors: Aurélie Foinard, Bertrand Décaudin, Christine Barthélémy, Bertrand Debaene and Pascal Odou

    Citation: Annals of Intensive Care 2012 2:28

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  7. Content type: Research

    The utility of endotracheal bioimpedance cardiography (ECOM) has been scarcely reported. We tested the hypothesis that it could be an alternative to pulse contour analysis for cardiac index measurement and pre...

    Authors: Jean-Luc Fellahi, Marc-Olivier Fischer, Audrey Dalbera, Massimo Massetti, Jean-Louis Gérard and Jean-Luc Hanouz

    Citation: Annals of Intensive Care 2012 2:26

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  8. Content type: Research

    The purpose of the present study was to quantify bacterial translocation to mesenteric lymph nodes due to different levels of intra-abdominal hypertension (IAH; 15 vs. 30 mmHg) lasting for 24 h in a porcine mo...

    Authors: Torsten Kaussen, Pramod Kadaba Srinivasan, Mamdouh Afify, Christiane Herweg, René Tolba, Joachim Conze and Alexander Schachtrupp

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S17

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    This article is part of a Supplement: Volume 2 Supplement 1

  9. Content type: Research

    Intra-abdominal hypertension [IAH] occurs frequently among critically ill patients and is associated with increased mortality and organ failure. Two porcine models of IAH that cause abdominal compartment syndr...

    Authors: Michael Moller, Ulrik K Kjerkegaard, Jens Rolighed Larsen, Hanne Birke-Sorensen and Lars B Stolle

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S16

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    This article is part of a Supplement: Volume 2 Supplement 1

  10. Content type: Research

    Achievement of a negative fluid balance in patients with capillary leak is associated with improved outcome. We investigated the effects of a multi-modal restrictive fluid strategy aiming for negative fluid ba...

    Authors: Colin Cordemans, Inneke De laet, Niels Van Regenmortel, Karen Schoonheydt, Hilde Dits, Greg Martin, Wolfgang Huber and Manu LNG Malbrain

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S15

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    This article is part of a Supplement: Volume 2 Supplement 1

  11. Content type: Research

    The development of intra-abdominal hypertension [IAH] in critically ill patients admitted to the ICU is an independent predictor of mortality. In an attempt to find an early, clinically relevant metabolic sign...

    Authors: Liivi Maddison, Juri Karjagin, Jyrki Tenhunen and Joel Starkopf

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S14

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    This article is part of a Supplement: Volume 2 Supplement 1

  12. Content type: Research

    Although the World Society for Abdominal Compartment Syndrome in its guidelines recommends midaxillary line (MAL) as zero reference level in intra-abdominal pressure (IAP) measurements in aiming at standardizi...

    Authors: Caridad De Dios Soler Morejón, Tomás Ariel Lombardo, Teddy Osmin Tamargo Barbeito and Barquín García Sandra

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S13

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    This article is part of a Supplement: Volume 2 Supplement 1

  13. Content type: Research

    Current assumptions rely on intra-abdominal pressure (IAP) being uniform across the abdominal cavity. The abdominal contents are, however, a heterogeneous mix of solid, liquid and gas, and pressure transmissio...

    Authors: Adrian B Cresswell, Wayel Jassem, Parthi Srinivasan, Andreas A Prachalias, Elizabeth Sizer, William Burnal, Georg Auzinger, Paolo Muiesan, Mohammed Rela, Nigel D Heaton, Matthew J Bowles and Julia A Wendon

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S12

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    This article is part of a Supplement: Volume 2 Supplement 1

  14. Content type: Research

    Intra-abdominal pressure (IAP) is most commonly measured via the bladder with the patient in the supine position. In the ICU, patients are nursed with the head of the bed elevated at 30° (HOB30) to reduce the ...

    Authors: Nirooshan Rooban, Adrian Regli, Wendy A Davis and Bart L De Keulenaer

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S11

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    This article is part of a Supplement: Volume 2 Supplement 1

  15. Content type: Research

    The aim of this study was to determine whether intra-abdominal pressure (IAP) monitoring using the FoleyManometer (Holtech Medical, Charlottenlund, Denmark) increases the risk of urinary tract infection (UTI).

    Authors: Nele Desie, Alexandra Willems, Inneke De laet, Hilde Dits, Niels Van Regenmortel, Karen Schoonheydt, Martine Van De Vyvere and Manu LNG Malbrain

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S10

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  16. Content type: Research

    Intra-abdominal pressure (IAP) is seldom measured by default in intensive care patients. This review summarises the current evidence on the prevalence and risk factors of intra-abdominal hypertension (IAH) to ...

    Authors: Joel Starkopf, Kadri Tamme and Annika Reintam Blaser

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S9

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    This article is part of a Supplement: Volume 2 Supplement 1

  17. Content type: Research

    Several decades ago, the beneficial effects of goal-directed therapy, which include decompressive laparotomy (DL) and open abdomen procedures in cases of intra-abdominal hypertension (IAH) in children, were pr...

    Authors: Torsten Kaussen, Gerd Steinau, Pramod Kadaba Srinivasan, Jens Otto, Michael Sasse, Franz Staudt and Alexander Schachtrupp

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S8

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  18. Content type: Research

    Abdominal compartment syndrome (ACS) is a life threatening condition that may affect any critically ill patient. Little is known about the recognition and management of ACS in Germany.

    Authors: Torsten Kaussen, Jens Otto, Gerd Steinau, Jörg Höer, Pramod Kadaba Srinivasan and Alexander Schachtrupp

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S7

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    This article is part of a Supplement: Volume 2 Supplement 1

  19. Content type: Research

    Abdominal compartment syndrome (ACS) is a syndrome associated with multi-system effects of elevated intra-abdominal pressure (IAP) in critically ill children. It has a 90-100% mortality rate if not recognized ...

    Authors: Jennifer Newcombe, Mudit Mathur, Khaled Bahjri and J Chiaka Ejike

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S6

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    This article is part of a Supplement: Volume 2 Supplement 1

  20. Content type: Research

    The last several decades have seen many advances in the recognition and prevention of the abdominal compartment syndrome (ACS) and its precursor, intra-abdominal hypertension (IAH). There has also been a relat...

    Authors: Rosaleen Chun and Andrew W Kirkpatrick

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S5

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    This article is part of a Supplement: Volume 2 Supplement 1

  21. Content type: Research

    The importance of intra-abdominal pressure (IAP) and abdominal perfusion pressure (APP) in cirrhotic patients with septic shock is not well studied. We evaluated the relationship between IAP and APP and outcom...

    Authors: Hasan M Al-Dorzi, Hani M Tamim, Asgar H Rishu, Abdulrahman Aljumah and Yaseen M Arabi

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S4

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    This article is part of a Supplement: Volume 2 Supplement 1

  22. Content type: Research

    The aim of this study was to determine the incidence of intra-abdominal hypertension (IAH) in patients with two or more categorized risk factors (CRF) for IAH, and their morbidity and mortality during their in...

    Authors: Patricia Santa-Teresa, Javier Muñoz, Ignacio Montero, María Zurita, María Tomey, Luis Álvarez-Sala and Pablo García

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S3

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    This article is part of a Supplement: Volume 2 Supplement 1

  23. Content type: Research

    Data on intra-abdominal hypertension [IAH] and secondary abdominal compartment syndrome [ACS] due to neurological insults are limited.

    Authors: Konstantin A Popugaev, Ivan A Savin, Andrew U Lubnin, Alexander S Goriachev, Boris A Kadashev, Pavel L Kalinin, Andrew V Oshorov, Alexander A Polupan, Ekaterina U Sokolova, Maxim A Kutin and Valeriy I Lukianov

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S2

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  24. Content type: Research

    Capillary leak in critically ill patients leads to interstitial edema. Fluid overload is independently associated with poor prognosis. Bedside measurement of intra-abdominal pressure (IAP), extravascular lung ...

    Authors: Colin Cordemans, Inneke De laet, Niels Van Regenmortel, Karen Schoonheydt, Hilde Dits, Wolfgang Huber and Manu LNG Malbrain

    Citation: Annals of Intensive Care 2012 2(Suppl 1):S1

    Published on:

    This article is part of a Supplement: Volume 2 Supplement 1

  25. Content type: Research

    The purpose of this study was to assess the short- and long-term outcomes of HIV-infected patients admitted to intensive care units (ICU) according to immunovirological status at admission and highly active an...

    Authors: David Morquin, Vincent Le Moing, Thibaut Mura, Alain Makinson, Kada Klouche, Olivier Jonquet, Jacques Reynes and Philippe Corne

    Citation: Annals of Intensive Care 2012 2:25

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  26. Content type: Review

    Because of its still rising incidence and high mortality rate in intensive care unit (ICU) patients, early recognition of acute kidney injury (AKI) remains a critical issue. Surprisingly, effective biomarkers ...

    Authors: Patrick M Honore, Rita Jacobs, Olivier Joannes-Boyau, Lies Verfaillie, Jouke De Regt, Viola Van Gorp, Elisabeth De Waele, Willem Boer, Vincent Collin and Herbert D Spapen

    Citation: Annals of Intensive Care 2012 2:24

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  27. Content type: Review

    French law allows organ donation after death due to cardiocirculatory arrest. In the Maastricht classification, type III non-heart-beating donors are those who experience cardiocirculatory arrest after the wit...

    Authors: Jean-Pierre Graftieaux, Pierre-Edouard Bollaert, Lise Haddad, Nancy Kentish-Barnes, Gérard Nitenberg, René Robert, Daniel Villers and Didier Dreyfuss

    Citation: Annals of Intensive Care 2012 2:23

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  28. Content type: Review

    The alarming global rise of antimicrobial resistance combined with the lack of new antimicrobial agents has led to a renewed interest in optimization of our current antibiotics. Continuous infusion (CI) of tim...

    Authors: Bruno Van Herendael, Axel Jeurissen, Paul M Tulkens, Erika Vlieghe, Walter Verbrugghe, Philippe G Jorens and Margareta Ieven

    Citation: Annals of Intensive Care 2012 2:22

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  29. Content type: Research

    Previous studies have shown a good agreement between central venous pressure (CVP) measurements from catheters placed in superior vena cava and catheters placed in the abdominal cava/common iliac vein. However...

    Authors: Hafid Ait-Oufella, Pierre-Yves Boelle, Arnaud Galbois, Jean-luc Baudel, Dimitri Margetis, Mikael Alves, Georges Offenstadt, Eric Maury and Bertrand Guidet

    Citation: Annals of Intensive Care 2012 2:21

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  30. Content type: Research

    Rapid response systems (RRSs) are considered an important tool for improving patient safety. We studied the effect of an RRS on the incidence of cardiac arrests and unexpected deaths.

    Authors: Friede M Simmes, Lisette Schoonhoven, Joke Mintjes, Bernard G Fikkers and Johannes G van der Hoeven

    Citation: Annals of Intensive Care 2012 2:20

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  31. Content type: Review

    The use or misuse of statins in critically ill patients recently attracted the attention of intensive care clinicians. Indeed, statins are probably the most common chronic treatment before critical illness and...

    Authors: Isabelle De Loecker and Jean-Charles Preiser

    Citation: Annals of Intensive Care 2012 2:19

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  32. Content type: Review

    Critical care delivery is a complex, expensive, error prone, medical specialty and remains the focal point of major improvement efforts in healthcare delivery. Various modeling and simulation techniques offer ...

    Authors: Yue Dong, Nicolas W Chbat, Ashish Gupta, Mirsad Hadzikadic and Ognjen Gajic

    Citation: Annals of Intensive Care 2012 2:18

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  33. Content type: Research

    Effective tight glycemic control (TGC) can improve outcomes in critical care patients, but it is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between insulin concentrati...

    Authors: Christopher G Pretty, Aaron J Le Compte, J Geoffrey Chase, Geoffrey M Shaw, Jean-Charles Preiser, Sophie Penning and Thomas Desaive

    Citation: Annals of Intensive Care 2012 2:17

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  34. Content type: Research

    We assessed the potential impact of infusion tubing on blood glucose imbalance in ICU patients given intensive insulin therapy (IIT). We compared the incidence of blood glucose imbalance in patients equipped, ...

    Authors: Eric Maury, Paola Vitry, Arnauld Galbois, Hafid Ait-Oufella, Jean-Luc Baudel, Bertrand Guidet and Georges Offenstadt

    Citation: Annals of Intensive Care 2012 2:16

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  35. Content type: Research

    A genomic biomarker identifying patients likely to benefit from drotrecogin alfa (activated) (DAA) may be clinically useful as a companion diagnostic. This trial was designed to validate biomarkers (improved r...

    Authors: Djillali Annane, Jean Paul Mira, Lorraine B Ware, Anthony C Gordon, Jonathan Sevransky, Frank Stüber, Patrick J Heagerty, Hugh F Wellman, Mauricio Neira, Alexandra DJ Mancini and James A Russell

    Citation: Annals of Intensive Care 2012 2:15

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  36. Content type: Review

    Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem ...

    Authors: Pierre Demaret, Geraldine Pettersen, Philippe Hubert, Pierre Teira and Guillaume Emeriaud

    Citation: Annals of Intensive Care 2012 2:14

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  37. Content type: Research

    Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (S...

    Authors: Charalampos Pierrakos, Fabio Silvio Taccone, Guy Decaux, Jean-Louis Vincent and Serge Brimioulle

    Citation: Annals of Intensive Care 2012 2:13

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  38. Content type: Research

    Central nervous system infection is a daily concern in neurointensive care; however, diagnosis remains difficult because classical criteria based on cerebrospinal fluid (CSF) analysis are difficult to interpre...

    Authors: Anne-Claire Lukaszewicz, Géraldine Gontier, Valérie Faivre, Ingrid Ouanounou and Didier Payen

    Citation: Annals of Intensive Care 2012 2:10

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  39. Content type: Research

    The passive leg-raising (PLR) maneuver provides a dynamic assessment of fluid responsiveness inducing a reversible increase in cardiac preload. Since its effects are sudden and transitory, a continuous cardiac...

    Authors: Manuel Ignacio Monge García, Anselmo Gil Cano, Manuel Gracia Romero, Rocío Monterroso Pintado, Virginia Pérez Madueño and Juan Carlos Díaz Monrové

    Citation: Annals of Intensive Care 2012 2:9

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  40. Content type: Review

    Cardiac biomarkers (CB) were first developed for assisting the diagnosis of cardiac events, especially acute myocardial infarction. The discoveries of other CB, the better understanding of cardiac disease proc...

    Authors: Anthony S McLean and Stephen J Huang

    Citation: Annals of Intensive Care 2012 2:8

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  41. Content type: Research

    Numerous cases of swine-origin 2009 H1N1 influenza A virus (H1N1)-associated acute respiratory distress syndrome (ARDS) bridged by extracorporeal membrane oxygenation (ECMO) therapy have been reported; however...

    Authors: Tobias M Bingold, Bertram Scheller, Timo Wolf, Jens Meier, Alexander Koch, Kai Zacharowski, Peter Rosenberger and Thomas Iber

    Citation: Annals of Intensive Care 2012 2:7

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  42. Content type: Review

    Candida and Aspergillus spp. are the most common agents responsible for invasive fungal infections in children. They are associated with a high mortality and morbidity rate as well as high health care costs. An ...

    Authors: Olivier Brissaud, Julie Guichoux, Jerome Harambat, Olivier Tandonnet and Theoklis Zaoutis

    Citation: Annals of Intensive Care 2012 2:6

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  43. Content type: Research

    Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF) in very old patients (≥ 80 years), often in the context of a do-not-intubate order (DNI). We aimed to dete...

    Authors: Frederique Schortgen, Arnaud Follin, Lucilla Piccari, Ferran Roche-Campo, Guillaume Carteaux, Elodie Taillandier-Heriche, Sebastien Krypciak, Arnaud W Thille, Elena Paillaud and Laurent Brochard

    Citation: Annals of Intensive Care 2012 2:5

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  44. Content type: Research

    Neurologists often diagnose brain death (BD) and explain BD to families in the intensive care unit. This study was designed to determine whether neurologists agree with the standard concept of death (irreversi...

    Authors: Ari R Joffe, Natalie R Anton, Jonathan P Duff and Allan deCaen

    Citation: Annals of Intensive Care 2012 2:4

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  45. Content type: Review

    Safety is a global concept that encompasses efficiency, security of care, reactivity of caregivers, and satisfaction of patients and relatives. Patient safety has emerged as a major target for healthcare impro...

    Authors: Maité Garrouste-Orgeas, François Philippart, Cédric Bruel, Adeline Max, Nicolas Lau and B Misset

    Citation: Annals of Intensive Care 2012 2:2

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