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  1. Content type: Research

    Rapid response systems (RRSs) are considered an important tool for improving patient safety. We studied the effect of an RRS on the incidence of cardiac arrests and unexpected deaths.

    Authors: Friede M Simmes, Lisette Schoonhoven, Joke Mintjes, Bernard G Fikkers and Johannes G van der Hoeven

    Citation: Annals of Intensive Care 2012 2:20

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  2. Content type: Review

    The use or misuse of statins in critically ill patients recently attracted the attention of intensive care clinicians. Indeed, statins are probably the most common chronic treatment before critical illness and...

    Authors: Isabelle De Loecker and Jean-Charles Preiser

    Citation: Annals of Intensive Care 2012 2:19

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  3. Content type: Review

    Critical care delivery is a complex, expensive, error prone, medical specialty and remains the focal point of major improvement efforts in healthcare delivery. Various modeling and simulation techniques offer ...

    Authors: Yue Dong, Nicolas W Chbat, Ashish Gupta, Mirsad Hadzikadic and Ognjen Gajic

    Citation: Annals of Intensive Care 2012 2:18

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  4. Content type: Research

    Effective tight glycemic control (TGC) can improve outcomes in critical care patients, but it is difficult to achieve consistently. Insulin sensitivity defines the metabolic balance between insulin concentrati...

    Authors: Christopher G Pretty, Aaron J Le Compte, J Geoffrey Chase, Geoffrey M Shaw, Jean-Charles Preiser, Sophie Penning and Thomas Desaive

    Citation: Annals of Intensive Care 2012 2:17

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  5. Content type: Research

    We assessed the potential impact of infusion tubing on blood glucose imbalance in ICU patients given intensive insulin therapy (IIT). We compared the incidence of blood glucose imbalance in patients equipped, ...

    Authors: Eric Maury, Paola Vitry, Arnauld Galbois, Hafid Ait-Oufella, Jean-Luc Baudel, Bertrand Guidet and Georges Offenstadt

    Citation: Annals of Intensive Care 2012 2:16

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  6. Content type: Research

    A genomic biomarker identifying patients likely to benefit from drotrecogin alfa (activated) (DAA) may be clinically useful as a companion diagnostic. This trial was designed to validate biomarkers (improved r...

    Authors: Djillali Annane, Jean Paul Mira, Lorraine B Ware, Anthony C Gordon, Jonathan Sevransky, Frank Stüber, Patrick J Heagerty, Hugh F Wellman, Mauricio Neira, Alexandra DJ Mancini and James A Russell

    Citation: Annals of Intensive Care 2012 2:15

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  7. Content type: Review

    Cancer is a leading cause of death in children. In the past decades, there has been a marked increase in overall survival of children with cancer. However, children whose treatment includes hematopoietic stem ...

    Authors: Pierre Demaret, Geraldine Pettersen, Philippe Hubert, Pierre Teira and Guillaume Emeriaud

    Citation: Annals of Intensive Care 2012 2:14

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  8. Content type: Research

    Hyponatremia occurring as a result of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) or cerebral salt wasting syndrome is a common complication in patients with subarachnoid hemorrhage (S...

    Authors: Charalampos Pierrakos, Fabio Silvio Taccone, Guy Decaux, Jean-Louis Vincent and Serge Brimioulle

    Citation: Annals of Intensive Care 2012 2:13

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  9. Content type: Research

    Central nervous system infection is a daily concern in neurointensive care; however, diagnosis remains difficult because classical criteria based on cerebrospinal fluid (CSF) analysis are difficult to interpre...

    Authors: Anne-Claire Lukaszewicz, Géraldine Gontier, Valérie Faivre, Ingrid Ouanounou and Didier Payen

    Citation: Annals of Intensive Care 2012 2:10

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  10. Content type: Research

    The passive leg-raising (PLR) maneuver provides a dynamic assessment of fluid responsiveness inducing a reversible increase in cardiac preload. Since its effects are sudden and transitory, a continuous cardiac...

    Authors: Manuel Ignacio Monge García, Anselmo Gil Cano, Manuel Gracia Romero, Rocío Monterroso Pintado, Virginia Pérez Madueño and Juan Carlos Díaz Monrové

    Citation: Annals of Intensive Care 2012 2:9

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  11. Content type: Review

    Cardiac biomarkers (CB) were first developed for assisting the diagnosis of cardiac events, especially acute myocardial infarction. The discoveries of other CB, the better understanding of cardiac disease proc...

    Authors: Anthony S McLean and Stephen J Huang

    Citation: Annals of Intensive Care 2012 2:8

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  12. Content type: Research

    Numerous cases of swine-origin 2009 H1N1 influenza A virus (H1N1)-associated acute respiratory distress syndrome (ARDS) bridged by extracorporeal membrane oxygenation (ECMO) therapy have been reported; however...

    Authors: Tobias M Bingold, Bertram Scheller, Timo Wolf, Jens Meier, Alexander Koch, Kai Zacharowski, Peter Rosenberger and Thomas Iber

    Citation: Annals of Intensive Care 2012 2:7

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  13. Content type: Review

    Candida and Aspergillus spp. are the most common agents responsible for invasive fungal infections in children. They are associated with a high mortality and morbidity rate as well as high health care costs. An ...

    Authors: Olivier Brissaud, Julie Guichoux, Jerome Harambat, Olivier Tandonnet and Theoklis Zaoutis

    Citation: Annals of Intensive Care 2012 2:6

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  14. Content type: Research

    Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF) in very old patients (≥ 80 years), often in the context of a do-not-intubate order (DNI). We aimed to dete...

    Authors: Frederique Schortgen, Arnaud Follin, Lucilla Piccari, Ferran Roche-Campo, Guillaume Carteaux, Elodie Taillandier-Heriche, Sebastien Krypciak, Arnaud W Thille, Elena Paillaud and Laurent Brochard

    Citation: Annals of Intensive Care 2012 2:5

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  15. Content type: Research

    Neurologists often diagnose brain death (BD) and explain BD to families in the intensive care unit. This study was designed to determine whether neurologists agree with the standard concept of death (irreversi...

    Authors: Ari R Joffe, Natalie R Anton, Jonathan P Duff and Allan deCaen

    Citation: Annals of Intensive Care 2012 2:4

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  16. Content type: Review

    Safety is a global concept that encompasses efficiency, security of care, reactivity of caregivers, and satisfaction of patients and relatives. Patient safety has emerged as a major target for healthcare impro...

    Authors: Maité Garrouste-Orgeas, François Philippart, Cédric Bruel, Adeline Max, Nicolas Lau and B Misset

    Citation: Annals of Intensive Care 2012 2:2

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  17. Content type: Review

    Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding o...

    Authors: Jean-Pierre Quenot, Christophe Milési, Aurély Cravoisy, Gilles Capellier, Olivier Mimoz, Olivier Fourcade and Pierre-Yves Gueugniaud

    Citation: Annals of Intensive Care 2012 2:1

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  18. Content type: Research

    Sepsis continues to be a poorly understood syndrome with a high mortality rate. While we are beginning to decipher the intricate interplay of the inflammatory response during sepsis, the precise regulation of ...

    Authors: Michael A Flierl, Daniel Rittirsch, Sebastian Weckbach, Markus Huber-Lang, Kyros Ipaktchi, Peter A Ward and Philip F Stahel

    Citation: Annals of Intensive Care 2011 1:53

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  19. Content type: Research

    Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin (PVL)-secreting Staphylococcus aureus is a highly lethal infection that mainly affects healthy children and young adults. Both methic...

    Authors: Lukas Kreienbuehl, Emmanuel Charbonney and Philippe Eggimann

    Citation: Annals of Intensive Care 2011 1:52

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  20. Content type: Research

    Although prompt initiation of appropriate antifungal therapy is essential for the control of invasive Candida infections and an improvement of prognosis, early diagnosis of invasive candidiasis remains a challeng...

    Authors: Guillaume Leroy, Fabien Lambiotte, Didier Thévenin, Christian Lemaire, Erika Parmentier, Patrick Devos and Olivier Leroy

    Citation: Annals of Intensive Care 2011 1:50

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  21. Content type: Research

    Hypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate...

    Authors: James Krinsley, Marcus J Schultz, Peter E Spronk, Floris van Braam Houckgeest, Johannes P van der Sluijs, Christian Mélot and Jean-Charles Preiser

    Citation: Annals of Intensive Care 2011 1:49

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  22. Content type: Research

    Microcirculation plays a vital role in the development of multiple organ failure in severe sepsis. The effects of red blood cell (RBC) transfusions on these tissue oxygenation and microcirculation variables in...

    Authors: Farid Sadaka, Ravi Aggu-Sher, Katie Krause, Jacklyn O'Brien, Eric S Armbrecht and Robert W Taylor

    Citation: Annals of Intensive Care 2011 1:46

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  23. Content type: Review

    The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enoug...

    Authors: Nicolas Mongardon, Florence Dumas, Sylvie Ricome, David Grimaldi, Tarik Hissem, Frédéric Pène and Alain Cariou

    Citation: Annals of Intensive Care 2011 1:45

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  24. Content type: Research

    This study was designed to investigate the effect of hypertonic fluid administration on inflammatory mediator gene expression in patients with septic shock.

    Authors: Frank MP van Haren, James Sleigh, Ray Cursons, Mary La Pine, Peter Pickkers and Johannes G van der Hoeven

    Citation: Annals of Intensive Care 2011 1:44

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  25. Content type: Review

    Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic...

    Authors: Christophe Lelubre and Jean-Louis Vincent

    Citation: Annals of Intensive Care 2011 1:43

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  26. Content type: Research

    Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilat...

    Authors: Stéphane Delisle, Paul Ouellet, Patrick Bellemare, Jean-Pierre Tétrault and Pierre Arsenault

    Citation: Annals of Intensive Care 2011 1:42

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  27. Content type: Review

    Mitochondrial functions include production of energy, activation of programmed cell death, and a number of cell specific tasks, e.g., cell signaling, control of Ca2+ metabolism, and synthesis of a number of impor...

    Authors: Andrey V Kozlov, Soheyl Bahrami, Enrico Calzia, Peter Dungel, Lars Gille, Andrey V Kuznetsov and Jakob Troppmair

    Citation: Annals of Intensive Care 2011 1:41

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  28. Content type: Review

    Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at...

    Authors: Nimesh SA Patel, Massimo Collino, Muhammad M Yaqoob and Christoph Thiemermann

    Citation: Annals of Intensive Care 2011 1:40

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  29. Content type: Review

    Stress-related cardiomyopathies can be observed in the four following situations: Takotsubo cardiomyopathy or apical ballooning syndrome; acute left ventricular dysfunction associated with subarachnoid hemorrh...

    Authors: Christian Richard

    Citation: Annals of Intensive Care 2011 1:39

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  30. Content type: Research

    Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- pati...

    Authors: Alicia Evans, Geoffrey M Shaw, Aaron Le Compte, Chia-Siong Tan, Logan Ward, James Steel, Christopher G Pretty, Leesa Pfeifer, Sophie Penning, Fatanah Suhaimi, Matthew Signal, Thomas Desaive and J Geoffrey Chase

    Citation: Annals of Intensive Care 2011 1:38

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  31. Content type: Review

    Invasive candidiasis ranges from 5 to 10 cases per 1,000 ICU admissions and represents 5% to 10% of all ICU-acquired infections, with an overall mortality comparable to that of severe sepsis/septic shock. A la...

    Authors: Philippe Eggimann, Jacques Bille and Oscar Marchetti

    Citation: Annals of Intensive Care 2011 1:37

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  32. Content type: Review

    Echocardiography is useful for the diagnosis and management of hemodynamic failure in the intensive care unit so that competence in some elements of echocardiography is a core skill of the critical care specia...

    Authors: Paul H Mayo

    Citation: Annals of Intensive Care 2011 1:36

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  33. Content type: Review

    Recent interest in functional hemodynamic monitoring for the bedside assessment of cardiovascular insufficiency has heightened. Functional hemodynamic monitoring is the assessment of the dynamic interactions o...

    Authors: Xaime García and Michael R Pinsky

    Citation: Annals of Intensive Care 2011 1:35

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  34. Content type: Review

    Catheters are the leading source of bloodstream infections for patients in the intensive care unit (ICU). Comprehensive unit-based programs have proven to be effective in decreasing catheter-related bloodstrea...

    Authors: Jean-François Timsit, Yohann Dubois, Clémence Minet, Agnès Bonadona, Maxime Lugosi, Claire Ara-Somohano, Rebecca Hamidfar-Roy and Carole Schwebel

    Citation: Annals of Intensive Care 2011 1:34

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  35. Content type: Research

    The diagnostic ability of computer-based methods for cardiovascular system (CVS) monitoring offers significant clinical potential. This research tests the clinical applicability of a newly improved computer-ba...

    Authors: James A Revie, David J Stevenson, J Geoffrey Chase, Christopher E Hann, Bernard C Lambermont, Alexandre Ghuysen, Philippe Kolh, Philippe Morimont, Geoffrey M Shaw and Thomas Desaive

    Citation: Annals of Intensive Care 2011 1:33

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  36. Content type: Review

    Evidence is accumulating showing that septic acute kidney injury (AKI) is different from non-septic AKI. Specifically, a large body of research points to apoptotic processes underlying septic AKI. Unravelling ...

    Authors: Patrick M Honore, Rita Jacobs, Olivier Joannes-Boyau, Jouke De Regt, Willem Boer, Elisabeth De Waele, Vincent Collin and Herbert D Spapen

    Citation: Annals of Intensive Care 2011 1:32

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  37. Content type: Research

    We hypothesized that bedside nurses perceive significant variability in the pediatric intensivist thresholds for approaching a family about withdrawal/limitation of life-sustaining therapy.

    Authors: Colleen S Gresiuk and Ari R Joffe

    Citation: Annals of Intensive Care 2011 1:31

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  38. Content type: Review

    The aging of the population has increased the demand for healthcare resources. The number of patients aged 80 years and older admitted to the intensive care unit (ICU) increased during the past decade, as has ...

    Authors: Yên-Lan Nguyen, Derek C Angus, Ariane Boumendil and Bertrand Guidet

    Citation: Annals of Intensive Care 2011 1:29

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  39. Content type: Review

    Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potential...

    Authors: Daniel De Backer, Katia Donadello, Fabio Silvio Taccone, Gustavo Ospina-Tascon, Diamantino Salgado and Jean-Louis Vincent

    Citation: Annals of Intensive Care 2011 1:27

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  40. Content type: Research

    Continuous infusion of vancomycin is increasingly preferred as an alternative to intermittent administration in critically ill patients. Intermittent vancomycin treatment is associated with an increased occurr...

    Authors: Herbert D Spapen, Karin Janssen van Doorn, Marc Diltoer, Walter Verbrugghe, Rita Jacobs, Nadia Dobbeleir, Patrick M Honoré and Philippe G Jorens

    Citation: Annals of Intensive Care 2011 1:26

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  41. Content type: Review

    Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, stand...

    Authors: Jan Wernerman

    Citation: Annals of Intensive Care 2011 1:25

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  42. Content type: Review

    Helium is a low-density inert gas whose physical properties are very different from those of nitrogen and oxygen. Such properties could be clinically useful in the adult critical care setting, especially in pa...

    Authors: J-L Diehl, V Peigne, E Guérot, C Faisy, L Lecourt and A Mercat

    Citation: Annals of Intensive Care 2011 1:24

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