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  1. Numerous cases of swine-origin 2009 H1N1 influenza A virus (H1N1)-associated acute respiratory distress syndrome (ARDS) bridged by extracorporeal membrane oxygenation (ECMO) therapy have been reported; however...

    Authors: Tobias M Bingold, Bertram Scheller, Timo Wolf, Jens Meier, Alexander Koch, Kai Zacharowski, Peter Rosenberger and Thomas Iber

    Citation: Annals of Intensive Care 2012 2:7

    Content type: Research

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  2. Candida and Aspergillus spp. are the most common agents responsible for invasive fungal infections in children. They are associated with a high mortality and morbidity rate as well as high health care costs. An ...

    Authors: Olivier Brissaud, Julie Guichoux, Jerome Harambat, Olivier Tandonnet and Theoklis Zaoutis

    Citation: Annals of Intensive Care 2012 2:6

    Content type: Review

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  3. Noninvasive ventilation (NIV) is frequently used for the management of acute respiratory failure (ARF) in very old patients (≥ 80 years), often in the context of a do-not-intubate order (DNI). We aimed to dete...

    Authors: Frederique Schortgen, Arnaud Follin, Lucilla Piccari, Ferran Roche-Campo, Guillaume Carteaux, Elodie Taillandier-Heriche, Sebastien Krypciak, Arnaud W Thille, Elena Paillaud and Laurent Brochard

    Citation: Annals of Intensive Care 2012 2:5

    Content type: Research

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  4. Neurologists often diagnose brain death (BD) and explain BD to families in the intensive care unit. This study was designed to determine whether neurologists agree with the standard concept of death (irreversi...

    Authors: Ari R Joffe, Natalie R Anton, Jonathan P Duff and Allan deCaen

    Citation: Annals of Intensive Care 2012 2:4

    Content type: Research

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  5. Safety is a global concept that encompasses efficiency, security of care, reactivity of caregivers, and satisfaction of patients and relatives. Patient safety has emerged as a major target for healthcare impro...

    Authors: Maité Garrouste-Orgeas, François Philippart, Cédric Bruel, Adeline Max, Nicolas Lau and B Misset

    Citation: Annals of Intensive Care 2012 2:2

    Content type: Review

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  6. Critically ill adult patients often require multiple examinations in the hospital and need transport from one department to another, or even between hospitals. However, to date, no guidelines exist regarding o...

    Authors: Jean-Pierre Quenot, Christophe Milési, Aurély Cravoisy, Gilles Capellier, Olivier Mimoz, Olivier Fourcade and Pierre-Yves Gueugniaud

    Citation: Annals of Intensive Care 2012 2:1

    Content type: Review

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  7. Sepsis continues to be a poorly understood syndrome with a high mortality rate. While we are beginning to decipher the intricate interplay of the inflammatory response during sepsis, the precise regulation of ...

    Authors: Michael A Flierl, Daniel Rittirsch, Sebastian Weckbach, Markus Huber-Lang, Kyros Ipaktchi, Peter A Ward and Philip F Stahel

    Citation: Annals of Intensive Care 2011 1:53

    Content type: Research

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  8. Community-acquired necrotizing pneumonia caused by Panton-Valentine leukocidin (PVL)-secreting Staphylococcus aureus is a highly lethal infection that mainly affects healthy children and young adults. Both methic...

    Authors: Lukas Kreienbuehl, Emmanuel Charbonney and Philippe Eggimann

    Citation: Annals of Intensive Care 2011 1:52

    Content type: Research

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  9. Although prompt initiation of appropriate antifungal therapy is essential for the control of invasive Candida infections and an improvement of prognosis, early diagnosis of invasive candidiasis remains a challeng...

    Authors: Guillaume Leroy, Fabien Lambiotte, Didier Thévenin, Christian Lemaire, Erika Parmentier, Patrick Devos and Olivier Leroy

    Citation: Annals of Intensive Care 2011 1:50

    Content type: Research

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  10. Hypoglycemia is associated with increased mortality in critically ill patients. The impact of hypoglycemia on resource utilization has not been investigated. The objective of this investigation was to evaluate...

    Authors: James Krinsley, Marcus J Schultz, Peter E Spronk, Floris van Braam Houckgeest, Johannes P van der Sluijs, Christian Mélot and Jean-Charles Preiser

    Citation: Annals of Intensive Care 2011 1:49

    Content type: Research

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  11. Microcirculation plays a vital role in the development of multiple organ failure in severe sepsis. The effects of red blood cell (RBC) transfusions on these tissue oxygenation and microcirculation variables in...

    Authors: Farid Sadaka, Ravi Aggu-Sher, Katie Krause, Jacklyn O'Brien, Eric S Armbrecht and Robert W Taylor

    Citation: Annals of Intensive Care 2011 1:46

    Content type: Research

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  12. The prognosis for postcardiac arrest patients remains very bleak, not only because of anoxic-ischemic neurological damage, but also because of the "postcardiac arrest syndrome," a phenomenon often severe enoug...

    Authors: Nicolas Mongardon, Florence Dumas, Sylvie Ricome, David Grimaldi, Tarik Hissem, Frédéric Pène and Alain Cariou

    Citation: Annals of Intensive Care 2011 1:45

    Content type: Review

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  13. This study was designed to investigate the effect of hypertonic fluid administration on inflammatory mediator gene expression in patients with septic shock.

    Authors: Frank MP van Haren, James Sleigh, Ray Cursons, Mary La Pine, Peter Pickkers and Johannes G van der Hoeven

    Citation: Annals of Intensive Care 2011 1:44

    Content type: Research

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  14. Red blood cell (RBC) transfusion is a common intervention in intensive care unit (ICU) patients. Anemia is frequent in this population and is associated with poor outcomes, especially in patients with ischemic...

    Authors: Christophe Lelubre and Jean-Louis Vincent

    Citation: Annals of Intensive Care 2011 1:43

    Content type: Review

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  15. Mechanical ventilation seems to occupy a major source in alteration in the quality and quantity of sleep among patients in intensive care. Quality of sleep is negatively affected with frequent patient-ventilat...

    Authors: Stéphane Delisle, Paul Ouellet, Patrick Bellemare, Jean-Pierre Tétrault and Pierre Arsenault

    Citation: Annals of Intensive Care 2011 1:42

    Content type: Research

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  16. Mitochondrial functions include production of energy, activation of programmed cell death, and a number of cell specific tasks, e.g., cell signaling, control of Ca2+ metabolism, and synthesis of a number of impor...

    Authors: Andrey V Kozlov, Soheyl Bahrami, Enrico Calzia, Peter Dungel, Lars Gille, Andrey V Kuznetsov and Jakob Troppmair

    Citation: Annals of Intensive Care 2011 1:41

    Content type: Review

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  17. Erythropoietin (EPO) is the major hormone stimulating the production and differentiation of red blood cells. EPO is used widely for treating anemia of critical illness or anemia induced by chemotherapy. EPO at...

    Authors: Nimesh SA Patel, Massimo Collino, Muhammad M Yaqoob and Christoph Thiemermann

    Citation: Annals of Intensive Care 2011 1:40

    Content type: Review

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  18. Stress-related cardiomyopathies can be observed in the four following situations: Takotsubo cardiomyopathy or apical ballooning syndrome; acute left ventricular dysfunction associated with subarachnoid hemorrh...

    Authors: Christian Richard

    Citation: Annals of Intensive Care 2011 1:39

    Content type: Review

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  19. Tight glycemic control (TGC) has shown benefits but has been difficult to achieve consistently. STAR (Stochastic TARgeted) is a flexible, model-based TGC approach directly accounting for intra- and inter- pati...

    Authors: Alicia Evans, Geoffrey M Shaw, Aaron Le Compte, Chia-Siong Tan, Logan Ward, James Steel, Christopher G Pretty, Leesa Pfeifer, Sophie Penning, Fatanah Suhaimi, Matthew Signal, Thomas Desaive and J Geoffrey Chase

    Citation: Annals of Intensive Care 2011 1:38

    Content type: Research

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  20. Invasive candidiasis ranges from 5 to 10 cases per 1,000 ICU admissions and represents 5% to 10% of all ICU-acquired infections, with an overall mortality comparable to that of severe sepsis/septic shock. A la...

    Authors: Philippe Eggimann, Jacques Bille and Oscar Marchetti

    Citation: Annals of Intensive Care 2011 1:37

    Content type: Review

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  21. Echocardiography is useful for the diagnosis and management of hemodynamic failure in the intensive care unit so that competence in some elements of echocardiography is a core skill of the critical care specia...

    Authors: Paul H Mayo

    Citation: Annals of Intensive Care 2011 1:36

    Content type: Review

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  22. Recent interest in functional hemodynamic monitoring for the bedside assessment of cardiovascular insufficiency has heightened. Functional hemodynamic monitoring is the assessment of the dynamic interactions o...

    Authors: Xaime García and Michael R Pinsky

    Citation: Annals of Intensive Care 2011 1:35

    Content type: Review

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  23. Catheters are the leading source of bloodstream infections for patients in the intensive care unit (ICU). Comprehensive unit-based programs have proven to be effective in decreasing catheter-related bloodstrea...

    Authors: Jean-François Timsit, Yohann Dubois, Clémence Minet, Agnès Bonadona, Maxime Lugosi, Claire Ara-Somohano, Rebecca Hamidfar-Roy and Carole Schwebel

    Citation: Annals of Intensive Care 2011 1:34

    Content type: Review

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  24. The diagnostic ability of computer-based methods for cardiovascular system (CVS) monitoring offers significant clinical potential. This research tests the clinical applicability of a newly improved computer-ba...

    Authors: James A Revie, David J Stevenson, J Geoffrey Chase, Christopher E Hann, Bernard C Lambermont, Alexandre Ghuysen, Philippe Kolh, Philippe Morimont, Geoffrey M Shaw and Thomas Desaive

    Citation: Annals of Intensive Care 2011 1:33

    Content type: Research

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  25. Evidence is accumulating showing that septic acute kidney injury (AKI) is different from non-septic AKI. Specifically, a large body of research points to apoptotic processes underlying septic AKI. Unravelling ...

    Authors: Patrick M Honore, Rita Jacobs, Olivier Joannes-Boyau, Jouke De Regt, Willem Boer, Elisabeth De Waele, Vincent Collin and Herbert D Spapen

    Citation: Annals of Intensive Care 2011 1:32

    Content type: Review

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  26. We hypothesized that bedside nurses perceive significant variability in the pediatric intensivist thresholds for approaching a family about withdrawal/limitation of life-sustaining therapy.

    Authors: Colleen S Gresiuk and Ari R Joffe

    Citation: Annals of Intensive Care 2011 1:31

    Content type: Research

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  27. The aging of the population has increased the demand for healthcare resources. The number of patients aged 80 years and older admitted to the intensive care unit (ICU) increased during the past decade, as has ...

    Authors: Yên-Lan Nguyen, Derek C Angus, Ariane Boumendil and Bertrand Guidet

    Citation: Annals of Intensive Care 2011 1:29

    Content type: Review

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  28. Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potential...

    Authors: Daniel De Backer, Katia Donadello, Fabio Silvio Taccone, Gustavo Ospina-Tascon, Diamantino Salgado and Jean-Louis Vincent

    Citation: Annals of Intensive Care 2011 1:27

    Content type: Review

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  29. Continuous infusion of vancomycin is increasingly preferred as an alternative to intermittent administration in critically ill patients. Intermittent vancomycin treatment is associated with an increased occurr...

    Authors: Herbert D Spapen, Karin Janssen van Doorn, Marc Diltoer, Walter Verbrugghe, Rita Jacobs, Nadia Dobbeleir, Patrick M Honoré and Philippe G Jorens

    Citation: Annals of Intensive Care 2011 1:26

    Content type: Research

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  30. Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, stand...

    Authors: Jan Wernerman

    Citation: Annals of Intensive Care 2011 1:25

    Content type: Review

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  31. Helium is a low-density inert gas whose physical properties are very different from those of nitrogen and oxygen. Such properties could be clinically useful in the adult critical care setting, especially in pa...

    Authors: J-L Diehl, V Peigne, E Guérot, C Faisy, L Lecourt and A Mercat

    Citation: Annals of Intensive Care 2011 1:24

    Content type: Review

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  32. Suspicion of sepsis in neutropenic patients requires immediate antimicrobial treatment. The initial regimen in critically ill patients should cover both Gram-positive and Gram-negative pathogens, including Pseudo...

    Authors: Matthieu Legrand, Adeline Max, Benoît Schlemmer, Elie Azoulay and Bertrand Gachot

    Citation: Annals of Intensive Care 2011 1:22

    Content type: Review

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  33. Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has a...

    Authors: MaryAnn Zhang, Raymond Hsu, Chi-yuan Hsu, Kristina Kordesch, Erica Nicasio, Alfredo Cortez, Ian McAlpine, Sandra Brady, Hanjing Zhuo, Kirsten N Kangelaris, John Stein, Carolyn S Calfee and Kathleen D Liu

    Citation: Annals of Intensive Care 2011 1:21

    Content type: Research

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  34. Given the persistent shortage of organs for transplantation, new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the ca...

    Authors: Lorraine B Ware, Tatsuki Koyama, Dean Billheimer, Megan Landeck, Elizabeth Johnson, Sandra Brady, Gordon R Bernard and Michael A Matthay

    Citation: Annals of Intensive Care 2011 1:20

    Content type: Research

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  35. Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dyn...

    Authors: Christophe Bordi and Sophie de Bentzmann

    Citation: Annals of Intensive Care 2011 1:19

    Content type: Review

    Published on:

  36. The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in ...

    Authors: Magda Cepkova, Vineet Kapur, Xiushui Ren, Thomas Quinn, Hanjing Zhuo, Elyse Foster, Michael A Matthay and Kathleen D Liu

    Citation: Annals of Intensive Care 2011 1:18

    Content type: Research

    Published on:

  37. The Surviving Sepsis Campaign is a global effort to improve the care of patients with severe sepsis and septic shock. The first Surviving Sepsis Campaign Guidelines were published in 2004 with an updated versi...

    Authors: Paul E Marik

    Citation: Annals of Intensive Care 2011 1:17

    Content type: Review

    Published on:

  38. ARDS is particularly characterized by pulmonary edema caused by an increase in pulmonary capillary permeability. It is considered that limiting pulmonary edema or accelerating its resorption through the modula...

    Authors: Antoine Roch, Christophe Guervilly and Laurent Papazian

    Citation: Annals of Intensive Care 2011 1:16

    Content type: Review

    Published on:

  39. Urine output often is used as a marker of acute kidney injury but also to guide fluid resuscitation in critically ill patients. Although decrease of urine output may be associated to a decrease of glomerular f...

    Authors: Matthieu Legrand and Didier Payen

    Citation: Annals of Intensive Care 2011 1:13

    Content type: Review

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  40. Critically ill patients are highly variable in their response to care and treatment. This variability and the search for improved outcomes have led to a significant increase in the use of protocolized care to ...

    Authors: J Geoffrey Chase, Aaron J Le Compte, J-C Preiser, Geoffrey M Shaw, Sophie Penning and Thomas Desaive

    Citation: Annals of Intensive Care 2011 1:11

    Content type: Review

    Published on:

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