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  1. To evaluate the diagnostic performances of two training programs for residents with no prior ultrasound experience to reach competences in extended basic critical care transthoracic echocardiography (CCE) incl...

    Authors: Vincent Labbé, Stéphane Ederhy, Blandine Pasquet, Romain Miguel-Montanes, Cédric Rafat, David Hajage, Stéphane Gaudry, Didier Dreyfuss, Ariel Cohen, Muriel Fartoukh and Jean-Damien Ricard
    Citation: Annals of Intensive Care 2016 6:44
  2. We aimed at assessing the benefit-to-risk ratio of activated protein C (drotrecogin-alfa activated, DAA) and corticosteroids, given alone or in combination, in patients with septic shock.

    Authors: Djillali Annane, Christian Brun Buisson, Alain Cariou, Claude Martin, Benoit Misset, Alain Renault, Blandine Lehmann, Valérie Millul, Virginie Maxime and Eric Bellissant
    Citation: Annals of Intensive Care 2016 6:43

    The Erratum to this article has been published in Annals of Intensive Care 2016 6:79

  3. Patients undergoing intermediate-risk surgery are typically taken to the ward postoperatively. However, some may develop complications requiring intensive care later. We aimed to evaluate the characteristics o...

    Authors: João M. Silva Jr., Helder Marcus Costa Rocha, Henrique Tadashi Katayama, Leandro Ferreira Dias, Mateus Barros de Paula, Leusi Magda Romano Andraus, Jose Maria Correa Silva and Luiz Marcelo Sá Malbouisson
    Citation: Annals of Intensive Care 2016 6:42

    The Erratum to this article has been published in Annals of Intensive Care 2016 6:78

  4. Early detection of infection is critical to rapidly starting effective treatment. Diagnosis can be difficult, particularly in the intensive care unit (ICU) population. Because the presence of polymorphonuclear...

    Authors: Jean Bardon, Anne-Claire Lukaszewicz, Valérie Faivre, Benjamin Huot and Didier Payen
    Citation: Annals of Intensive Care 2016 6:41
  5. Two sets of diagnostic criteria of paediatric multiple organ dysfunction syndrome (MODS) were published by Proulx in 1996 and by Goldstein in 2005. We hypothesized that this changes the epidemiology of MODS. T...

    Authors: Andréanne Villeneuve, Jean-Sébastien Joyal, François Proulx, Thierry Ducruet, Nicole Poitras and Jacques Lacroix
    Citation: Annals of Intensive Care 2016 6:40
  6. Data on circulating total antioxidant capacity (TAC) levels in ischemic stroke patients compared with healthy controls are limited and provided conflicting findings. There are not data about the association be...

    Authors: Leonardo Lorente, María M. Martín, Antonia Pérez-Cejas, Pedro Abreu-González, Luis Ramos, Mónica Argueso, Juan J. Cáceres, Jordi Solé-Violán and Alejandro Jiménez
    Citation: Annals of Intensive Care 2016 6:39
  7. Changeovers of norepinephrine infusion pumps (CNIPs) frequently lead to haemodynamic instability. The aim of this study was to identify risk factors for haemodynamic instability associated with CNIP, independe...

    Authors: Martin Cour, Thomas Bénet, Romain Hernu, Marie Simon, Thomas Baudry, Philippe Vanhems and Laurent Argaud
    Citation: Annals of Intensive Care 2016 6:38
  8. EtCO2 variation has been advocated replacing cardiac output measurements to evaluate fluid responsiveness (FR) during sepsis. The ability of EtCO2 variation after a fluid challenge to detect FR in the context of...

    Authors: Matthias Jacquet-Lagrèze, Florent Baudin, Jean Stéphane David, Jean-Luc Fellahi, Patrick B. Hu, Marc Lilot and Vincent Piriou
    Citation: Annals of Intensive Care 2016 6:37
  9. Left ventricular (LV) diastolic dysfunction is highly prevalent in the general population and associated with a significant morbidity and mortality. Its prognostic role in patients sustaining septic shock in t...

    Authors: Céline Gonzalez, Emmanuelle Begot, François Dalmay, Nicolas Pichon, Bruno François, Anne-Laure Fedou, Catherine Chapellas, Antoine Galy, Claire Mancia, Thomas Daix and Philippe Vignon
    Citation: Annals of Intensive Care 2016 6:36
  10. Gram-negative pneumonia in patients who are intubated and mechanically ventilated is associated with increased morbidity and mortality as well as higher healthcare costs compared with those who do not have the...

    Authors: Matteo Bassetti, Charles-Edouard Luyt, David P. Nicolau and Jérôme Pugin
    Citation: Annals of Intensive Care 2016 6:35
  11. Despite the significant impact of nosocomial infections on the morbidity and mortality of patients staying in the intensive care unit (ICU), no study over the past 20 years has focused specifically on VAP foll...

    Authors: María Heredia-Rodríguez, María Teresa Peláez, Inmaculada Fierro, Esther Gómez-Sánchez, Estefanía Gómez-Pesquera, Mario Lorenzo, F. Javier Álvarez-González, Juan Bustamante-Munguira, José María Eiros, Jesús F. Bermejo-Martin, José I. Gómez-Herreras and Eduardo Tamayo
    Citation: Annals of Intensive Care 2016 6:34
  12. Pulmonary coagulopathy is a characteristic feature of lung injury including ventilator-induced lung injury. The aim of this individual patient data meta-analysis is to assess the effects of nebulized anticoag...

    Authors: Gerie J. Glas, Ary Serpa Neto, Janneke Horn, Amalia Cochran, Barry Dixon, Elamin M. Elamin, Iris Faraklas, Sharmila Dissanaike, Andrew C. Miller and Marcus J. Schultz
    Citation: Annals of Intensive Care 2016 6:33
  13. Prediction of diagnosis of ventilator-associated pneumonia (VAP) remains difficult. Our aim was to assess the value of biomarker kinetics in VAP prediction.

    Authors: Pedro Póvoa, Ignacio Martin-Loeches, Paula Ramirez, Lieuwe D. Bos, Mariano Esperatti, Joana Silvestre, Gisela Gili, Gema Goma, Eugenio Berlanga, Mateu Espasa, Elsa Gonçalves, Antoni Torres and Antonio Artigas
    Citation: Annals of Intensive Care 2016 6:32
  14. Outcome of very elderly patients admitted in intensive care unit (ICU) was most often reported for octogenarians. ICU admission demands for nonagenarians are increasing. The primary objective was to compare ou...

    Authors: Maité Garrouste-Orgeas, Stéphane Ruckly, Charles Grégoire, Anne-Sylvie Dumesnil, Cécile Pommier, Samir Jamali, Dany Golgran-Toledano, Carole Schwebel, Christophe Clec’h, Lilia Soufir, Muriel Fartoukh, Guillaume Marcotte, Laurent Argaud, Bruno Verdière, Michael Darmon, Elie Azoulay…
    Citation: Annals of Intensive Care 2016 6:31
  15. Proportional assist ventilation+ (PAV+) delivers airway pressure (P aw) in proportion to patient effort (P mus) by using the equation of motion of the respira...

    Authors: Francois Beloncle, Evangelia Akoumianaki, Nuttapol Rittayamai, Aissam Lyazidi and Laurent Brochard
    Citation: Annals of Intensive Care 2016 6:30
  16. Severity of cerebral venous thrombosis (CVT) may require the transfer to intensive care unit (ICU). This report described the context for CVT transfer to ICU, the strategy of care and the outcome after 1 year.

    Authors: Benjamin Soyer, Marco Rusca, Anne-Claire Lukaszewicz, Isabelle Crassard, Jean-Pierre Guichard, Damien Bresson, Joaquim Mateo and Didier Payen
    Citation: Annals of Intensive Care 2016 6:29

    The Erratum to this article has been published in Annals of Intensive Care 2016 6:108

  17. cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions...

    Authors: Julie Toubiana, Emilie Courtine, Frederic Tores, Pierre Asfar, Cédric Daubin, Christophe Rousseau, Fatah Ouaaz, Nathalie Marin, Alain Cariou, Jean-Daniel Chiche and Jean-Paul Mira
    Citation: Annals of Intensive Care 2016 6:28
  18. Our aim was to evaluate the impact of a computerized echocardiographic simulator on the learning curve for transesophageal echocardiography (TEE) hemodynamic assessment of ventilated patients in the ICU.

    Authors: Gwénaël Prat, Cyril Charron, Xavier Repesse, Pierre Coriat, Pierre Bailly, Erwan L’her and Antoine Vieillard-Baron
    Citation: Annals of Intensive Care 2016 6:27
  19. Cases of ventilator-associated pneumonia (VAP) due to multidrug-resistant (MDR) gram-negative bacilli (GNB) mainly Acinetobacter baumannii, Pseudomonas aeruginosa and enterobacteria are common in hospitalised pat...

    Authors: Sami Abdellatif, Ahlem Trifi, Foued Daly, Khaoula Mahjoub, Rochdi Nasri and Salah Ben Lakhal
    Citation: Annals of Intensive Care 2016 6:26
  20. Aneurysmal subarachnoid hemorrhage (SAH) is a serious condition associated with high mortality rates and long-term disability. We investigated the impact of fluid balance on neurologic outcome after adjustment...

    Authors: Yasser Sakr, Pedro Dünisch, Clesar Santos, Lena Matthes, Mohamed Zeidan, Konrad Reinhart, Rolf Kalff and Christian Ewald
    Citation: Annals of Intensive Care 2016 6:25
  21. The changes in metabolic pathways and metabolites due to critical illness result in a highly complex and dynamic metabolic state, making safe, effective management of hyperglycemia and hypoglycemia difficult. ...

    Authors: Kent W. Stewart, Christopher G. Pretty, Hamish Tomlinson, Felicity L. Thomas, József Homlok, Szabó Némedi Noémi, Attila Illyés, Geoffrey M. Shaw, Balázs Benyó and J. Geoffrey Chase
    Citation: Annals of Intensive Care 2016 6:24
  22. This review gives an overview of current knowledge on hyperoxia pathophysiology and examines experimental and human evidence of hyperoxia effects after cardiac arrest. Oxygen plays a pivotal role in critical c...

    Authors: Jean-François Llitjos, Jean-Paul Mira, Jacques Duranteau and Alain Cariou
    Citation: Annals of Intensive Care 2016 6:23
  23. Dysnatremia is associated with adverse outcome in critically ill patients. Changes in patients or treatment strategies may have affected the incidence of dysnatremia over time. We investigated long-term change...

    Authors: Annemieke Oude Lansink-Hartgring, Lara Hessels, Joachim Weigel, Anne Marie G. A. de Smet, Diederik Gommers, Prashant V. Nannan Panday, Ewout J. Hoorn and Maarten W. Nijsten
    Citation: Annals of Intensive Care 2016 6:22
  24. Endothelial progenitor cells (EPCs) have been suggested to constitute a restoration index of the disturbed endothelium in ICU patients. Neuromuscular electric stimulation (NMES) is increasingly employed in ICU...

    Authors: Christos Stefanou, Eleftherios Karatzanos, Georgios Mitsiou, Katerina Psarra, Epameinondas Angelopoulos, Stavros Dimopoulos, Vasiliki Gerovasili, Efstathios Boviatsis, Christina Routsi and Serafeim Nanas
    Citation: Annals of Intensive Care 2016 6:21
  25. Previous studies have suggested that prediction models for mortality should be adjusted for additional risk factors beyond the Acute Physiology and Chronic Health Evaluation (APACHE) score. Our objective was ...

    Authors: Guowei Li, Lehana Thabane, Deborah J. Cook, Renato D. Lopes, John C. Marshall, Gordon Guyatt, Anne Holbrook, Noori Akhtar-Danesh, Robert A. Fowler, Neill K. J. Adhikari, Rob Taylor, Yaseen M. Arabi, Dean Chittock, Peter Dodek, Andreas P. Freitag, Stephen D. Walter…
    Citation: Annals of Intensive Care 2016 6:18
  26. Several promising therapies assessed in the adult critically ill in large, multicenter randomized controlled trials (RCTs) were associated with significantly increased mortality in the intervention arms. Our h...

    Authors: James A. Russell and Mark D. Williams
    Citation: Annals of Intensive Care 2016 6:17
  27. Indirect calorimetry (IC) is the reference method for measurement of energy expenditure (EE) in mechanically ventilated critically ill patients. When IC is unavailable, EE can be calculated by predictive equat...

    Authors: Mark Lillelund Rousing, Mie Hviid Hahn-Pedersen, Steen Andreassen, Ulrike Pielmeier and Jean-Charles Preiser
    Citation: Annals of Intensive Care 2016 6:16
  28. Digital innovations are changing medicine, and hemodynamic monitoring will not be an exception. Five to ten years from now, we can envision a world where clinicians will learn hemodynamics with simulators and ...

    Authors: Frederic Michard
    Citation: Annals of Intensive Care 2016 6:15
  29. Cardiogenic shock which corresponds to an acute state of circulatory failure due to impairment of myocardial contractility is a very rare disease in children, even more than in adults. To date, no internationa...

    Authors: Olivier Brissaud, Astrid Botte, Gilles Cambonie, Stéphane Dauger, Laure de Saint Blanquat, Philippe Durand, Véronique Gournay, Elodie Guillet, Daniela Laux, Francis Leclerc, Philippe Mauriat, Thierry Boulain and Khaldoun Kuteifan
    Citation: Annals of Intensive Care 2016 6:14
  30. Esophageal pressure is used as a reliable surrogate of the pleural pressure. It is conventionally measured by an esophageal balloon placed in the lower part of the esophagus. To validate the correct position ...

    Authors: Davide Chiumello, Dario Consonni, Silvia Coppola, Sara Froio, Francesco Crimella and Andrea Colombo
    Citation: Annals of Intensive Care 2016 6:13
  31. Termination of resuscitation rule permits to stop futile resuscitative efforts by paramedics. In a different setting, the decision to withhold resuscitation by emergency physician could be based on different f...

    Authors: Jean-Christophe Orban, Didier Giolito, Jordan Tosi, Franck Le Duff, Nicolas Boissier, Christophe Mamino, Emmanuelle Molinatti, Thai Se Ung, Yassine Kabsy, Nicolas Fraimout, Julie Contenti and Jacques Levraut
    Citation: Annals of Intensive Care 2016 6:12
  32. In sedated and paralyzed children with acute respiratory failure, the compliance of respiratory system and functional residual capacity were significantly reduced compared with healthy subjects. However, no m...

    Authors: Davide Chiumello, Giovanna Chidini, Edoardo Calderini, Andrea Colombo, Francesco Crimella and Matteo Brioni
    Citation: Annals of Intensive Care 2016 6:11
  33. To evaluate the ability of the central venous-to-arterial CO2 content and tension differences to arteriovenous oxygen content difference ratios (∆ContCO2/∆ContO2 and ∆PCO2/∆ContO2, respectively), blood lactate co...

    Authors: Jihad Mallat, Malcolm Lemyze, Mehdi Meddour, Florent Pepy, Gaelle Gasan, Stephanie Barrailler, Emmanuelle Durville, Johanna Temime, Nicolas Vangrunderbeeck, Laurent Tronchon, Benoît Vallet and Didier Thevenin
    Citation: Annals of Intensive Care 2016 6:10
  34. The objectives of the study were to estimate the incidence of intensive care unit (ICU) admissions due to adverse drug events (ADEs), to assess preventability, severity and costs of the corresponding ADE and t...

    Authors: Pierre-Alain Jolivot, Claire Pichereau, Patrick Hindlet, Gilles Hejblum, Naïke Bigé, Eric Maury, Bertrand Guidet and Christine Fernandez
    Citation: Annals of Intensive Care 2016 6:9
  35. Clinical features and outcomes of patients with spontaneous ilio-psoas hematoma (IPH) in intensive care units (ICUs) are poorly documented. The objectives of this study were to determine epidemiological, clin...

    Authors: J. F. Llitjos, F. Daviaud, D. Grimaldi, S. Legriel, J. L. Georges, E. Guerot, J. P. Bedos, J. Y. Fagon, J. Charpentier and J. P. Mira
    Citation: Annals of Intensive Care 2016 6:8
  36. Intensive care unit (ICU) patients are aging, and older age has been associated with higher mortality in ICU. As previous studies have reported that older age was also associated with less intensive treatment,...

    Authors: Vincent Peigne, Dominique Somme, Emmanuel Guérot, Emilie Lenain, Gilles Chatellier, Jean-Yves Fagon and Olivier Saint-Jean
    Citation: Annals of Intensive Care 2016 6:7
  37. Breakdown of renal endothelial, tubular and glomerular matrix collagen plays a major role in acute kidney injury (AKI) development. Such collagen breakdown releases endostatin into the circulation. The aim of ...

    Authors: Johan Mårtensson, Niklas Jonsson, Neil J. Glassford, Max Bell, Claes-Roland Martling, Rinaldo Bellomo and Anders Larsson
    Citation: Annals of Intensive Care 2016 6:6
  38. Before discharging a patient from the ICU, an adequate patient evaluation is needed to detect individuals as high risk for unfavorable outcome. A pro- or anti-inflammatory status is a potential risk factor fo...

    Authors: S. Sophie Gülcher, Nynke A. Bruins, W. Peter Kingma and E. Christiaan Boerma
    Citation: Annals of Intensive Care 2016 6:5
  39. Therapeutic hypothermia (TH between 32 and 34 °C) was recommended until recently in unconscious successfully resuscitated cardiac arrest (CA) patients, especially after initial shockable rhythm. A randomized c...

    Authors: Nicolas Deye, François Vincent, Philippe Michel, Stephan Ehrmann, Daniel da Silva, Michael Piagnerelli, Antoine Kimmoun, Olfa Hamzaoui, Jean-Claude Lacherade, Bernard de Jonghe, Florence Brouard, Corinne Audoin, Xavier Monnet and Pierre-François Laterre
    Citation: Annals of Intensive Care 2016 6:4
  40. Due to the limited data available in the pediatric population and lack of interventional studies to show that administration of vitamin D indeed improves clinical outcomes, opinion is still divided as to wheth...

    Authors: Jhuma Sankar, Wonashi Lotha, Javed Ismail, C. Anubhuti, Rameshwar S. Meena and M. Jeeva Sankar
    Citation: Annals of Intensive Care 2016 6:3
  41. In the context of recent guidelines on invasive candidiasis (IC), how French intensive care units (ICUs) are managing IC?

    Authors: Olivier Leroy, Sébastien Bailly, Jean-Pierre Gangneux, Jean-Paul Mira, Patrick Devos, Hervé Dupont, Philippe Montravers, Pierre-François Perrigault, Jean-Michel Constantin, Didier Guillemot, Elie Azoulay, Olivier Lortholary, Caroline Bensoussan and Jean-François Timsit
    Citation: Annals of Intensive Care 2016 6:2
  42. Hyponatremia is the most common electrolyte disturbance in hospitalized patients, and it represents a well-established risk factor for ICU/hospital mortality. The majority of hyponatremic states are associated...

    Authors: Michele Umbrello, Elena S. Mantovani, Paolo Formenti, Claudia Casiraghi, Davide Ottolina, Martina Taverna, Angelo Pezzi, Giovanni Mistraletti and Gaetano Iapichino
    Citation: Annals of Intensive Care 2016 6:1
  43. Acute renal failure (ARF) in critically ill patients is currently very frequent and requires renal replacement therapy (RRT) in many patients. During the last 15 years, several studies have considered importan...

    Authors: Christophe Vinsonneau, Emma Allain-Launay, Clarisse Blayau, Michael Darmon, Damien du Cheyron, Theophile Gaillot, Patrick M. Honore, Etienne Javouhey, Thierry Krummel, Annie Lahoche, Serge Letacon, Matthieu Legrand, Mehran Monchi, Christophe Ridel, René Robert, Frederique Schortgen…
    Citation: Annals of Intensive Care 2015 5:58
  44. Early after intubation, a layer of biofilm covers the inner lumen of the endotracheal tube (ETT). Cleaning the ETT might prevent airways colonization by pathogens, reduce resistance to airflow, and decrease su...

    Authors: Andrea Coppadoro, Giacomo Bellani, Alfio Bronco, Alberto Lucchini, Simone Bramati, Vanessa Zambelli, Roberto Marcolin and Antonio Pesenti
    Citation: Annals of Intensive Care 2015 5:57
  45. Echocardiography and the N-terminal pro-brain-type natriuretic peptide (NT-proBNP) level are important tests for assessing left ventricular function in patients presenting to the emergency department with acute d...

    Authors: Zouheir Bitar, Ossama Maadarani and Khaled Almerri
    Citation: Annals of Intensive Care 2015 5:56
  46. The potential influence of bed availability on triage to intensive care unit (ICU) admission is among the factors that may influence the ideal ratio of ICU beds to population: thus, high bed availability (HBA)...

    Authors: René Robert, Rémi Coudroy, Stéphanie Ragot, Olivier Lesieur, Isabelle Runge, Vincent Souday, Arnaud Desachy, Jean-Paul Gouello, Michel Hira, Mouldi Hamrouni and Jean Reignier
    Citation: Annals of Intensive Care 2015 5:55
  47. While a systematic approach to weaning reduces the rate of extubation failure in intubated brain-injured patients, no data are available on the weaning outcome of these patients after tracheotomy. We aimed to ...

    Authors: Rosanna Vaschetto, Pamela Frigerio, Maurizio Sommariva, Arianna Boggero, Valentina Rondi, Francesca Grossi, Silvio Cavuto, Stefano Nava, Francesco Della Corte and Paolo Navalesi
    Citation: Annals of Intensive Care 2015 5:54
  48. Since the overall prognosis of very elderly patients is generally limited, admissions to intensive care in these patients are often restricted. Therefore, only very few information is available on the prognosi...

    Authors: Sophie Becker, Jakob Müller, Geraldine de Heer, Stephan Braune, Valentin Fuhrmann and Stefan Kluge
    Citation: Annals of Intensive Care 2015 5:53

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