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  1. Multiple experimental and human trials have shown that microcirculatory alterations are frequent in sepsis. In this review, we discuss the characteristics of these alterations, the various mechanisms potential...

    Authors: Daniel De Backer, Katia Donadello, Fabio Silvio Taccone, Gustavo Ospina-Tascon, Diamantino Salgado and Jean-Louis Vincent
    Citation: Annals of Intensive Care 2011 1:27
  2. Continuous infusion of vancomycin is increasingly preferred as an alternative to intermittent administration in critically ill patients. Intermittent vancomycin treatment is associated with an increased occurr...

    Authors: Herbert D Spapen, Karin Janssen van Doorn, Marc Diltoer, Walter Verbrugghe, Rita Jacobs, Nadia Dobbeleir, Patrick M Honoré and Philippe G Jorens
    Citation: Annals of Intensive Care 2011 1:26
  3. Intravenous glutamine supplementation is standard care when parenteral nutrition is given for critical illness. There are data of a reduced mortality when glutamine supplementation is given. In addition, stand...

    Authors: Jan Wernerman
    Citation: Annals of Intensive Care 2011 1:25
  4. Helium is a low-density inert gas whose physical properties are very different from those of nitrogen and oxygen. Such properties could be clinically useful in the adult critical care setting, especially in pa...

    Authors: J-L Diehl, V Peigne, E Guérot, C Faisy, L Lecourt and A Mercat
    Citation: Annals of Intensive Care 2011 1:24
  5. Suspicion of sepsis in neutropenic patients requires immediate antimicrobial treatment. The initial regimen in critically ill patients should cover both Gram-positive and Gram-negative pathogens, including Pseudo...

    Authors: Matthieu Legrand, Adeline Max, Benoît Schlemmer, Elie Azoulay and Bertrand Gachot
    Citation: Annals of Intensive Care 2011 1:22
  6. Fibroblast growth factor-23 (FGF-23), a novel regulator of mineral metabolism, is markedly elevated in chronic kidney disease and has been associated with poor long-term outcomes. However, whether FGF-23 has a...

    Authors: MaryAnn Zhang, Raymond Hsu, Chi-yuan Hsu, Kristina Kordesch, Erica Nicasio, Alfredo Cortez, Ian McAlpine, Sandra Brady, Hanjing Zhuo, Kirsten N Kangelaris, John Stein, Carolyn S Calfee and Kathleen D Liu
    Citation: Annals of Intensive Care 2011 1:21
  7. Given the persistent shortage of organs for transplantation, new donor management strategies to improve both organ utilization and quality of procured organs are needed. Current management protocols for the ca...

    Authors: Lorraine B Ware, Tatsuki Koyama, Dean Billheimer, Megan Landeck, Elizabeth Johnson, Sandra Brady, Gordon R Bernard and Michael A Matthay
    Citation: Annals of Intensive Care 2011 1:20
  8. Microbiologists have extensively worked during the past decade on a particular phase of the bacterial cell cycle known as biofilm, in which single-celled individuals gather together to form a sedentary but dyn...

    Authors: Christophe Bordi and Sophie de Bentzmann
    Citation: Annals of Intensive Care 2011 1:19
  9. The primary objective of this study was to examine levels of B-type natriuretic peptide (BNP) in mechanically ventilated patients with acute lung injury and to test whether the level of BNP would be higher in ...

    Authors: Magda Cepkova, Vineet Kapur, Xiushui Ren, Thomas Quinn, Hanjing Zhuo, Elyse Foster, Michael A Matthay and Kathleen D Liu
    Citation: Annals of Intensive Care 2011 1:18
  10. The Surviving Sepsis Campaign is a global effort to improve the care of patients with severe sepsis and septic shock. The first Surviving Sepsis Campaign Guidelines were published in 2004 with an updated versi...

    Authors: Paul E Marik
    Citation: Annals of Intensive Care 2011 1:17
  11. ARDS is particularly characterized by pulmonary edema caused by an increase in pulmonary capillary permeability. It is considered that limiting pulmonary edema or accelerating its resorption through the modula...

    Authors: Antoine Roch, Christophe Guervilly and Laurent Papazian
    Citation: Annals of Intensive Care 2011 1:16
  12. Urine output often is used as a marker of acute kidney injury but also to guide fluid resuscitation in critically ill patients. Although decrease of urine output may be associated to a decrease of glomerular f...

    Authors: Matthieu Legrand and Didier Payen
    Citation: Annals of Intensive Care 2011 1:13
  13. Critically ill patients are highly variable in their response to care and treatment. This variability and the search for improved outcomes have led to a significant increase in the use of protocolized care to ...

    Authors: J Geoffrey Chase, Aaron J Le Compte, J-C Preiser, Geoffrey M Shaw, Sophie Penning and Thomas Desaive
    Citation: Annals of Intensive Care 2011 1:11
  14. Recruitment maneuvers (RM) consist of a ventilatory strategy that increases the transpulmonary pressure transiently to reopen the recruitable lung units in acute respiratory distress syndrome (ARDS). The ratio...

    Authors: Claude Guerin, Sophie Debord, Véronique Leray, Bertrand Delannoy, Frédérique Bayle, Gael Bourdin and Jean-Christophe Richard
    Citation: Annals of Intensive Care 2011 1:9
  15. Depression of left ventricular (LV) intrinsic contractility is constant in patients with septic shock. Because most parameters of cardiac function are strongly dependent on afterload, especially in this contex...

    Authors: Antoine Vieillard-Baron
    Citation: Annals of Intensive Care 2011 1:6
  16. A few decades have passed since intensive care unit (ICU) beds have been available for critically ill patients with cancer. Although the initial reports showed dismal prognosis, recent data suggest that an inc...

    Authors: Elie Azoulay, Marcio Soares, Michael Darmon, Dominique Benoit, Stephen Pastores and Bekele Afessa
    Citation: Annals of Intensive Care 2011 1:5
  17. Chest x-rays (CXRs) are the main imaging tool in intensive care units (ICUs). CXRs also are associated with concerns inherent to their use, considering both healthcare organization and patient perspectives. In...

    Authors: Vincent Ioos, Arnaud Galbois, Ludivine Chalumeau-Lemoine, Bertrand Guidet, Eric Maury and Gilles Hejblum
    Citation: Annals of Intensive Care 2011 1:4
  18. Erythropoietin (EPO) is a 30.4 kDa glycoprotein produced by the kidney, and is mostly well-known for its physiological function in regulating red blood cell production in the bone marrow. Accumulating evidence...

    Authors: Elizabeth Moore and Rinaldo Bellomo
    Citation: Annals of Intensive Care 2011 1:3
  19. The clinical determination of the intravascular volume can be extremely difficult in critically ill and injured patients as well as those undergoing major surgery. This is problematic because fluid loading is ...

    Authors: Paul E Marik, Xavier Monnet and Jean-Louis Teboul
    Citation: Annals of Intensive Care 2011 1:1

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