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Articles
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Citation: Annals of Intensive Care 2024 14:90
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Impaired angiotensin II signaling in septic shock
Recent years have seen a resurgence of interest for the renin–angiotensin–aldosterone system in critically ill patients. Emerging data suggest that this vital homeostatic system, which plays a crucial role in ...
Citation: Annals of Intensive Care 2024 14:89 -
Lung ultrasound for causal diagnosis of shock (FALLS-protocol), a tool helping to guide fluid therapy while approaching fluid tolerance. Some comments on its accuracy
Citation: Annals of Intensive Care 2024 14:88 -
Correction: COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
Citation: Annals of Intensive Care 2024 14:87 -
Basing intubation of acutely hypoxemic patients on physiologic principles
The decision to intubate a patient with acute hypoxemic respiratory failure who is not in apparent respiratory distress is one of the most difficult clinical decisions faced by intensivists. A conservative app...
Citation: Annals of Intensive Care 2024 14:86 -
Impact of extended lung protection during mechanical ventilation on lung recovery in patients with COVID-19 ARDS: a phase II randomized controlled trial
Protective ventilation seems crucial during early Acute Respiratory Distress Syndrome (ARDS), but the optimal duration of lung protection remains undefined. High driving pressures (ΔP) and excessive patient ve...
Citation: Annals of Intensive Care 2024 14:85 -
Trajectory pattern of serially measured acute kidney injury biomarkers in critically ill patients: a prospective observational study
The clinical value of the trajectory of temporal changes in acute kidney injury (AKI) biomarkers has not been well established among intensive care unit (ICU) patients.
Citation: Annals of Intensive Care 2024 14:84 -
Immunosuppression at ICU admission is not associated with a higher incidence of ICU-acquired bacterial bloodstream infections: the COCONUT study
Immunosuppression at intensive care unit (ICU) admission has been associated with a higher incidence of ICU-acquired infections, some of them related to opportunistic pathogens. However, the association of imm...
Citation: Annals of Intensive Care 2024 14:83 -
Challenges in investigating “Gut barrier dysfunction and bacterial translocation in ICU-acquired bacteremia”
Citation: Annals of Intensive Care 2024 14:82 -
Correction: Cefiderocol in Difficult-to-Treat Nf-GNB in ICU Settings
Citation: Annals of Intensive Care 2024 14:81 -
Pneumocystis pneumonia in French intensive care units in 2013–2019: mortality and immunocompromised conditions
The recent epidemiology of Pneumocystis pneumonia (PCP) requiring intensive care unit (ICU) admission and the associated spectrum of immunocompromising conditions are poorly described.
Citation: Annals of Intensive Care 2024 14:80 -
Renin in critically ill patients
The renin-angiotensin system (RAS) constitutes one of the principal mechanisms to maintain hemodynamic and fluid homeostasis. However, most research until now on RAS primarily focuses on its relationship with ...
Citation: Annals of Intensive Care 2024 14:79 -
Reverse triggering ? a novel or previously missed phenomenon?
Reverse triggering (RT) was described in 2013 as a form of patient-ventilator asynchrony, where patient’s respiratory effort follows mechanical insufflation. Diagnosis requires esophageal pressure (Pes) or diaphr...
Citation: Annals of Intensive Care 2024 14:78 -
Family centeredness of care: a cross-sectional study in intensive care units part of the European society of intensive care medicine
To identify key components and variations in family-centered care practices.
Citation: Annals of Intensive Care 2024 14:77 -
Monitoring monocyte HLA-DR expression and CD4 + T lymphocyte count in dexamethasone-treated severe COVID-19 patients
A 10-day dexamethasone regimen has emerged as the internationally adopted standard-of-care for severe COVID-19 patients. However, the immune response triggered by SARS-CoV-2 infection remains a complex and dyn...
Citation: Annals of Intensive Care 2024 14:76 -
Immunostimulation in critically ill patients: do not forget to consider the timing, stratification, and monitoring
Citation: Annals of Intensive Care 2024 14:75 -
Comparison of the prognosis among in-hospital survivors of cardiogenic shock based on etiology: AMI and Non-AMI
Current data on post-discharge mortality and rehospitalization is still insufficient among in-hospital survivors of cardiogenic shock (CS), including acute myocardial infarction (AMI) and non-AMI survivors.
Citation: Annals of Intensive Care 2024 14:74 -
Cefiderocol in Difficult-to-Treat Nf-GNB in ICU Settings
The efficacy and safety of cefiderocol in ICU patients with difficult-to-treat resistance (DTR) non-fermenting Gram-negative bacteria (Nf-GNB) are not as well-established. Consequently, we conducted a cohort s...
Citation: Annals of Intensive Care 2024 14:73 -
Pulmonary redox imbalance drives early fibroproliferative response in moderate/severe coronavirus disease-19 acute respiratory distress syndrome and impacts long-term lung abnormalities
COVID-19-associated pulmonary fibrosis remains frequent. This study aimed to investigate pulmonary redox balance in COVID-19 ARDS patients and possible relationship with pulmonary fibrosis and long-term lung a...
Citation: Annals of Intensive Care 2024 14:72 -
Critical care beyond organ support: the importance of geriatric rehabilitation
Very old critically ill patients pose a growing challenge for intensive care. Critical illness and the burden of treatment in the intensive care unit (ICU) can lead to a long-lasting decline of functional and ...
Citation: Annals of Intensive Care 2024 14:71 -
Hospital-acquired bloodstream infections in critically ill cirrhotic patients: a post-hoc analysis of the EUROBACT-2 international cohort study
Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are especially susceptible to infections, yet there is a knowledge g...
Citation: Annals of Intensive Care 2024 14:70 -
Community-acquired Klebsiella pneumoniae pneumonia in ICU: a multicenter retrospective study
Alongside the recent worldwide expansion of hypervirulent Klebsiella pneumoniae (KP) infections, the available literature regarding cases of community acquired pneumonias (KP-CAP) remains scarce but reports a str...
Citation: Annals of Intensive Care 2024 14:69 -
Conservative versus liberal oxygen therapy for intensive care unit patients: meta-analysis of randomized controlled trials
It remains unclear whether conservative oxygen therapy (COT) or liberal oxygen therapy (LOT) is more beneficial to the clinical outcomes of intensive care unit (ICU) patients. We systematically reviewed the ef...
Citation: Annals of Intensive Care 2024 14:68 -
Recurrent ventilator-associated pneumonia in severe Covid-19 ARDS patients requiring ECMO support
To describe ventilator-associated pneumonia (VAP) recurrence in COVID-19 patients requiring extracorporeal membrane oxygenation (ECMO) support, and to evaluate the impact of antimicrobial treatment duration of...
Citation: Annals of Intensive Care 2024 14:67 -
Efficacy and safety of antibiotics targeting Gram-negative bacteria in nosocomial pneumonia: a systematic review and Bayesian network meta-analysis
Multiple randomized controlled studies have compared numerous antibiotic regimens, including new, recently commercialized antibiotics in the treatment of nosocomial pneumonia (NP). The objective of this Bayesi...
Citation: Annals of Intensive Care 2024 14:66 -
COVID-19 associated pulmonary aspergillosis in critically-ill patients: a prospective multicenter study in the era of Delta and Omicron variants
During the first COVID-19 pandemic wave, COVID-19-associated pulmonary aspergillosis (CAPA) has been reported in up to 11–28% of critically ill COVID-19 patients and associated with increased mortality. As new...
Citation: Annals of Intensive Care 2024 14:65 -
Managing sepsis and septic shock in an endothelial glycocalyx-friendly way: from the viewpoint of surviving sepsis campaign guidelines
Maintaining tissue perfusion in sepsis depends on vascular integrity provided by the endothelial glycocalyx, the critical layer covering the luminal surface of blood vessels. The glycocalyx is composed of prot...
Citation: Annals of Intensive Care 2024 14:64 -
Rebuttal to the letter “Assessment of COVID-19-related right ventricular morphological and functional alterations and evaluation of their impact on the course of the disease”
Citation: Annals of Intensive Care 2024 14:63 -
Methodological considerations in personalized methods for PEEP optimization with electrical impedance tomography
Citation: Annals of Intensive Care 2024 14:62 -
Microbiological features of drowning-associated pneumonia: a systematic review and meta-analysis
Drowning-associated pneumonia (DAP) is frequent in drowned patients, and possibly increases mortality. A better understanding of the microorganisms causing DAP could improve the adequacy of empirical antimicro...
Citation: Annals of Intensive Care 2024 14:61 -
Combined cardiac, lung, and diaphragm ultrasound for predicting weaning failure during spontaneous breathing trial
Weaning from invasive mechanical ventilation (MV) is a complex and challenging process that involves multiple pathophysiological mechanisms. A combined ultrasound evaluation of the heart, lungs, and diaphragm ...
Citation: Annals of Intensive Care 2024 14:60 -
Spontaneous breathing trial with pressure support on positive end-expiratory pressure and extensive use of non-invasive ventilation versus T-piece in difficult-to-wean patients from mechanical ventilation: a randomized controlled trial
The aim of this study is to assess whether a strategy combining spontaneous breathing trial (SBT) with both pressure support (PS) and positive end-expiratory pressure (PEEP) and extended use of post-extubation...
Citation: Annals of Intensive Care 2024 14:59 -
The chain of survival and rehabilitation for sepsis: concepts and proposals for healthcare trajectory optimization
This article describes the structures and processes involved in healthcare delivery for sepsis, from the prehospital setting until rehabilitation. Quality improvement initiatives in sepsis may reduce both morb...
Citation: Annals of Intensive Care 2024 14:58 -
Impact of therapeutic plasmapheresis on the duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis
Plasmapheresis is widely used for severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP) to remove excessive triglycerides from plasma. This study aimed to evaluate whether plasmapheresis could imp...
Citation: Annals of Intensive Care 2024 14:57 -
Oxygenation management during veno-arterial ECMO support for cardiogenic shock: a multicentric retrospective cohort study
Hyperoxemia is common and associated with poor outcome during veno-arterial extracorporeal membrane oxygenation (VA ECMO) support for cardiogenic shock. However, little is known about practical daily managemen...
Citation: Annals of Intensive Care 2024 14:56 -
Factors associated with adverse outcome among children with sickle cell disease admitted to the pediatric intensive care unit: an observational cohort
Sickle cell disease (SCD) is one of the most frequent inherited diseases in the world. Over the last decades, in high-income countries, an important decrease in mortality have been observed due to the improvem...
Citation: Annals of Intensive Care 2024 14:55 -
Association of socioeconomic deprivation with outcomes in critically ill adult patients: an observational prospective multicenter cohort study
The influence of socioeconomic deprivation on health inequalities is established, but its effect on critically ill patients remains unclear, due to inconsistent definitions in previous studies.
Citation: Annals of Intensive Care 2024 14:54 -
Effect of volume infusion on left atrial strain in acute circulatory failure
Left atrial strain (LAS) is a measure of atrial wall deformation during cardiac cycle and reflects atrial contribution to cardiovascular performance. Pathophysiological significance of LAS in critically ill pa...
Citation: Annals of Intensive Care 2024 14:53 -
Influence of fluid accumulation on major adverse kidney events in critically ill patients – an observational cohort study
Fluid accumulation (FA) is known to be associated with acute kidney injury (AKI) during intensive care unit (ICU) stay but data on mid-term renal outcome is scarce. The aim of this study was to investigate the...
Citation: Annals of Intensive Care 2024 14:52 -
Severe Legionnaires’ disease
Legionnaires’ disease (LD) is a common but under-diagnosed cause of community-acquired pneumonia (CAP), although rapid detection of urine antigen testing (UAT) and advances in molecular testing have improved t...
Citation: Annals of Intensive Care 2024 14:51 -
Positive end-expiratory pressure and left ventricular function are key factors affecting right ventricular to pulmonary arterial coupling
Citation: Annals of Intensive Care 2024 14:50 -
Capillary refill time response to a fluid challenge or a vasopressor test: an observational, proof-of-concept study
Several studies have validated capillary refill time (CRT) as a marker of tissue hypoperfusion, and recent guidelines recommend CRT monitoring during septic shock resuscitation. Therefore, it is relevant to fu...
Citation: Annals of Intensive Care 2024 14:49 -
Should initial ICU admission become a standard of care for acute bacterial meningitis ?
Citation: Annals of Intensive Care 2024 14:48 -
Pressure for change: can we continue to ignore the lack of evidence for blood pressure augmentation to treat delayed neurological deficit following subarachnoid haemorrhage?
Citation: Annals of Intensive Care 2024 14:47 -
The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years
Premorbid conditions influence the outcome of acutely ill adult patients aged 80 years and over who are admitted to the ICU. The aim of this study was to determine the influence of such premorbid conditions on...
Citation: Annals of Intensive Care 2024 14:46 -
Management of cardiogenic shock: a narrative review
Cardiogenic shock (CS) is characterized by low cardiac output and sustained tissue hypoperfusion that may result in end-organ dysfunction and death. CS is associated with high short-term mortality, and its man...
Citation: Annals of Intensive Care 2024 14:45 -
Clinical description and outcome of overall varicella-zoster virus-related organ dysfunctions admitted in intensive care units: the VAZOREA cohort study
Due to aging population and increasing part of immunocompromised patients, a raise in life-threatening organ damage related to VZV can be expected. Two retrospective studies were already conducted on VZV in IC...
Citation: Annals of Intensive Care 2024 14:44 -
Serial daily lactate levels association with 30-day outcome in cardiogenic shock patients treated with VA-ECMO: a post-hoc analysis of the HYPO-ECMO study
Reliable predictors of outcomes in venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy are limited. While elevated lactate levels over time have been linked to outcomes in cardiogenic shock (CS)...
Citation: Annals of Intensive Care 2024 14:43 -
Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case–control study
Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative ...
Citation: Annals of Intensive Care 2024 14:42 -
Early sevoflurane sedation in severe COVID-19-related lung injury patients. A pilot randomized controlled trial
This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from C...
Citation: Annals of Intensive Care 2024 14:41
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