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Annals of Intensive Care
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  1. Left ventricular ejection fraction (LVEF) is inconsistently associated with poor outcomes in patients with sepsis. Newer parameters such as LV longitudinal strain (LVLS), mitral annular plane systolic excursio...

    Authors: Patrik Johansson Blixt, Maxime Nguyen, Bernard Cholley, Fredrik Hammarskjöld, Alois Toiron, Belaid Bouhemad, Shaun Lee, Lina De Geer, Henrik Andersson, Meriam Åström Aneq, Jan Engvall and Michelle S. Chew
    Citation: Annals of Intensive Care 2024 14:12
    Content type: Research Published on:

  2. Previously, we reported a decreased mortality rate among patients with COVID-19 who were admitted at the ICU during the final upsurge of the second wave (February–June 2021) in the Netherlands. We examined whe...

    Authors: Fabian Termorshuizen, Dave A. Dongelmans, Sylvia Brinkman, Ferishta Bakhshi-Raiez, M. Sesmu Arbous, Dylan W. de Lange, Bas C. T. van Bussel and Nicolette F. de Keizer
    Citation: Annals of Intensive Care 2024 14:11
    Content type: Research Published on:

  3. Right ventricular (RV) function is tightly coupled to afterload, yet echocardiographic indices of RV function are frequently assessed in isolation. Normalizing RV function for afterload (RV-PA coupling) using ...

    Authors: Emma Bowcock, Stephen Huang, Rachel Yeo, Deshani Walisundara, Chris F. Duncan, Faraz Pathan, Geoffrey Strange, David Playford and Sam Orde
    Citation: Annals of Intensive Care 2024 14:10
    Content type: Research Published on:

  4. Healthcare expenses are increasing, as is the utilization of laboratory resources. Despite this, between 20% and 40% of requested tests are deemed inappropriate. Improper use of laboratory resources leads to u...

    Authors: Luigi Devis, Emilie Catry, Patrick M. Honore, Alexandre Mansour, Giuseppe Lippi, François Mullier and Mélanie Closset
    Citation: Annals of Intensive Care 2024 14:9
    Content type: Review Published on:

  7. Sepsis is a significant public health concern, particularly affecting individuals above 70 years in developed countries. This is a crucial fact due to the increasing aging population, their heightened vulnerab...

    Authors: Mercedes Ibarz, Lenneke E. M. Haas, Adrián Ceccato and Antonio Artigas
    Citation: Annals of Intensive Care 2024 14:6
    Content type: Review Published on:

  8. Authors: A. S. Giordani, A. Baritussio, R. Marcolongo and A. L. P. Caforio
    Citation: Annals of Intensive Care 2024 14:5
    Content type: Letter to the Editor Published on:

    The original article was published in Annals of Intensive Care 2023 13:78

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:3

  9. Aquaporin-4 immunoglobulin G Neuro Myelitis Optica spectrum disorders attacks (NMOSD-AQP4-IgG+ attacks) can cause respiratory failure requiring orotracheal intubation (OTI), but the risk factors and outcomes o...

    Authors: Edouard Januel, Vincent Brochard, Loïc Le Guennec, Elisabeth Maillart, Céline Louapre, Catherine Lubetzki, Nicolas Weiss, Sophie Demeret and Caroline Papeix
    Citation: Annals of Intensive Care 2024 14:4
    Content type: Research Published on:

  10. Authors: Marc Pineton de Chambrun, Yann Marquet, Mathieu Kerneis, Matthieu Schmidt, Charles-Edouard Luyt, Alain Combes and Guillaume Hekimian
    Citation: Annals of Intensive Care 2024 14:3
    Content type: Letter to the Editor Published on:

    The original article was published in Annals of Intensive Care 2024 14:5

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:5

  11. Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irres...

    Authors: Paula Martín-Vicente, Cecilia López-Martínez, Beatriz Rioseras and Guillermo M. Albaiceta
    Citation: Annals of Intensive Care 2024 14:2
    Content type: Review Published on:

  12. Various Positive End-Expiratory Pressure (PEEP) titration strategies have been proposed to optimize ventilation in patients with acute respiratory distress syndrome (ARDS). We aimed to compare PEEP titration s...

    Authors: Bertrand Pavlovsky, Christophe Desprez, Jean-Christophe Richard, Nicolas Fage, Arnaud Lesimple, Dara Chean, Antonin Courtais, Tommaso Mauri, Alain Mercat and François Beloncle
    Citation: Annals of Intensive Care 2024 14:1
    Content type: Research Published on:

  13. During Pressure Support Ventilation (PSV) an inspiratory hold allows to measure plateau pressure (Pplat), driving pressure (∆P), respiratory system compliance (Crs) and pressure-muscle-index (PMI), an index of...

    Authors: Mattia Docci, Emanuele Rezoagli, Maddalena Teggia-Droghi, Andrea Coppadoro, Matteo Pozzi, Alice Grassi, Isabella Bianchi, Giuseppe Foti and Giacomo Bellani
    Citation: Annals of Intensive Care 2023 13:132
    Content type: Research Published on:

  14. Internal redistribution of gas, referred to as pendelluft, is a new potential mechanism of effort-dependent lung injury. Neurally-adjusted ventilatory assist (NAVA) and proportional assist ventilation (PAV +) ...

    Authors: Daniel H. Arellano, Roberto Brito, Caio C. A. Morais, Pablo Ruiz-Rudolph, Abraham I. J. Gajardo, Dannette V. Guiñez, Marioli T. Lazo, Ivan Ramirez, Verónica A. Rojas, María A. Cerda, Juan N. Medel, Victor Illanes, Nivia R. Estuardo, Alejandro R. Bruhn, Laurent J. Brochard, Marcelo B. P. Amato…
    Citation: Annals of Intensive Care 2023 13:131
    Content type: Research Published on:

  15. Little attention has been paid to potential differences in prognosis between mechanically ventilated males and females in intensive care units (ICUs). We hypothesized that a sex gap in the risk of extubation f...

    Authors: Arnaud W. Thille, Florence Boissier, Rémi Coudroy, Sylvain Le Pape, François Arrivé, Laura Marchasson, Jean-Pierre Frat and Stéphanie Ragot
    Citation: Annals of Intensive Care 2023 13:130
    Content type: Research Published on:

  16. Although it has been reported that patients with pneumococcal pneumonia may develop meningitis, lumbar puncture is not systematically recommended in these patients, even in patients with associated bacteremia ...

    Authors: Paul Jaubert, Julien Charpentier, Sarah Benghanem, Alain Cariou, Frédéric Pène, Jean-Paul Mira and Mathieu Jozwiak
    Citation: Annals of Intensive Care 2023 13:129
    Content type: Research Published on:

  17. The physiological effects of renin-angiotensin system modulation in acute respiratory distress syndrome (ARDS) remain controversial and have not been investigated in randomized trials. We sought to determine w...

    Authors: Daniel E. Leisman, Damian R. Handisides, Lakhmir S. Chawla, Timothy E. Albertson, Laurence W. Busse, David W. Boldt, Adam M. Deane, Michelle N. Gong, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, B. Taylor Thompson, James S. Tumlin, Christopher D. Adams, Tony N. Hodges…
    Citation: Annals of Intensive Care 2023 13:128
    Content type: Research Published on:

  18. Endotoxin adsorption is a promising but controversial therapy in severe, refractory septic shock and conflicting results exist on the effective capacity of available devices to reduce circulating endotoxin and...

    Authors: Pedro David Wendel-Garcia, Barbara Eberle, Eva-Maria Kleinert, Matthias Peter Hilty, Stephan Blumenthal, Katharina Spanaus, Patricia Fodor and Marco Maggiorini
    Citation: Annals of Intensive Care 2023 13:127
    Content type: Research Published on:

  19. Frailty is widely acknowledged as influencing health outcomes among critically ill old patients. Yet, the traditional understanding of its impact has predominantly been through frequentist statistics. We endea...

    Authors: Bernhard Wernly, Raphael Romano Bruno, Michael Beil, Hans Flaatten, Malte Kelm, Sviri Sigal, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Andreas Koköfer, Sandra Oeyen, Brian Marsh, Rui Moreno, Sarah Wernly, Susannah Leaver, Dylan W. De Lange…
    Citation: Annals of Intensive Care 2023 13:126
    Content type: Research Published on:

  20. The administration technique for inhaled drug delivery during invasive ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition of a radiolabeled aerosol generated through f...

    Authors: Jonathan Dugernier, Déborah Le Pennec, Guillaume Maerckx, Laurine Allimonnier, Michel Hesse, Diego Castanares-Zapatero, Virginie Depoortere, Laurent Vecellio, Gregory Reychler, Jean-Bernard Michotte, Pierre Goffette, Marie-Agnes Docquier, Christian Raftopoulos, François Jamar, Pierre-François Laterre, Stephan Ehrmann…
    Citation: Annals of Intensive Care 2023 13:125
    Content type: Research Published on:

  21. Patients with bacterial meningitis can be severely ill necessitating intensive care unit (ICU) treatment. Here, we describe clinical features and prognostic factors of adults with bacterial meningitis admitted...

    Authors: Nora Chekrouni, Merel Kroon, Evelien H. G. M. Drost, Thijs M. van Soest, Merijn. W. Bijlsma, Matthijs C. Brouwer and Diederik van de Beek
    Citation: Annals of Intensive Care 2023 13:124
    Content type: Research Published on:

  22. In the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic lymphocytic leukemia (CLL) and several non-Hodgkin lymphoma. Beyond Bruton...

    Authors: Louise Baucher, Virginie Lemiale, Adrien Joseph, Florent Wallet, Marc Pineton de Chambrun, Alexis Ferré, Romain Lombardi, Laura Platon, Adrien Contejean, Charline Fuseau, Laure Calvet, Frédéric Pène, Achille Kouatchet, Djamel Mokart, Elie Azoulay and Antoine Lafarge
    Citation: Annals of Intensive Care 2023 13:123
    Content type: Research Published on:

  23. The unsuccessful extubation in patients with traumatic cervical spinal cord injuries (CSCI) may result from impairment diaphragm function and monitoring of diaphragm electrical activity (EAdi) can be informati...

    Authors: Rui Zhang, Xiaoting Xu, Hui Chen, Jennifer Beck, Christer Sinderby, Haibo Qiu, Yi Yang and Ling Liu
    Citation: Annals of Intensive Care 2023 13:122
    Content type: Research Published on:

  24. The prolonged β-lactam antibiotics infusion has been an attractive strategy in severe infections, because it provides a more stable free drug concentration and a longer duration of free drug concentration abov...

    Authors: Xiaoming Li, Yi Long, Guixin Wu, Rui Li, Mingming Zhou, Aiting He and Zhengying Jiang
    Citation: Annals of Intensive Care 2023 13:121
    Content type: Research Published on:

  25. Authors: Roberto Roncon-Albuquerque Jr, Sérgio Gaião, Francisco Vasques-Nóvoa, Carla Basílio, Ana Rita Ferreira, Alberto Touceda-Bravo, Rodrigo Pimentel, Ana Vaz, Sofia Silva, Guiomar Castro, Tiago Veiga, Hélio Martins, Francisco Dias, Catarina Pereira, Gonçalo Marto, Isabel Coimbra…
    Citation: Annals of Intensive Care 2023 13:120
    Content type: Letter to the Editor Published on:

    The original article was published in Annals of Intensive Care 2023 13:118

    The Research to this article has been published in Annals of Intensive Care 2023 13:86

  26. Disseminated intravascular coagulation (DIC) worsens the prognosis of septic shock and contributes to multiple organ failure. To date, no data linking DIC and acute kidney injury (AKI) occurrence, severity, an...

    Authors: Julie Helms, Hamid Merdji, Sébastien Loewert, François Severac, Alexandra Monnier, Julian Kaurin, Anaïs Curtiaud, Ferhat Meziani and Julien Demiselle
    Citation: Annals of Intensive Care 2023 13:119
    Content type: Research Published on:

  27. Authors: Alessandro Belletti, Jacopo D’Andria Ursoleo, Anna Mara Scandroglio, Giovanni Landoni and Alberto Zangrillo
    Citation: Annals of Intensive Care 2023 13:118
    Content type: Letter to the Editor Published on:

    The original article was published in Annals of Intensive Care 2023 13:86

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2023 13:120

  29. Multiple devices are available for noninvasive oxygenation support, including non-rebreather oxygen mask (O2-mask), high-flow oxygen through nasal cannula (HFNC), continuous positive airway pressure (CPAP), mask ...

    Authors: Anne-Fleur Haudebourg, Tommaso Maraffi, Samuel Tuffet, Philippe Le Corvoisier, Armand Mekontso Dessap and Guillaume Carteaux
    Citation: Annals of Intensive Care 2023 13:116
    Content type: Research Published on:

  30. Critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requiring veno-venous extracorporeal membrane oxygenation (vv-ECMO) are at risk for acute kidney injury (AKI). Currentl...

    Authors: Kevin Roedl, Silvia De Rosa, Marlene Fischer, Josephine Braunsteiner, Christian Schmidt-Lauber, Dominik Jarczak, Tobias B. Huber, Stefan Kluge and Dominic Wichmann
    Citation: Annals of Intensive Care 2023 13:115
    Content type: Research Published on:

  31. The effectiveness of high-flow nasal cannula oxygen therapy (HFNC) in patients with acute respiratory failure due to COVID-19 remains uncertain. We aimed at assessing whether HFNC is associated with reduced ri...

    Authors: Sylvain Le Pape, Sigourney Savart, François Arrivé, Jean-Pierre Frat, Stéphanie Ragot, Rémi Coudroy and Arnaud W. Thille
    Citation: Annals of Intensive Care 2023 13:114
    Content type: Research Published on:

  32. We aimed to study the incidence of acute kidney injury (AKI) in out-of-hospital cardiac arrest (OHCA) patients treated according to low-normal or high-normal mean arterial pressure (MAP) targets.

    Authors: Johanna Laurikkala, Koen Ameloot, Matti Reinikainen, Pieter-Jan Palmers, Cathy De Deyne, Ferdinande Bert, Matthias Dupont, Stefan Janssens, Joseph Dens, Johanna Hästbacka, Pekka Jakkula, Pekka Loisa, Thomas Birkelund, Erika Wilkman, Suvi T. Vaara and Markus B. Skrifvars
    Citation: Annals of Intensive Care 2023 13:113
    Content type: Research Published on:

  33. Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave.

    Authors: Philipp Kloss, Maximilian Lindholz, Annette Milnik, Elie Azoulay, Maurizio Cecconi, Giuseppe Citerio, Thomas De Corte, Frantisek Duska, Laura Galarza, Massimiliano Greco, Armand R. J. Girbes, Jozef Kesecioglu, Johannes Mellinghoff, Marlies Ostermann, Mariangela Pellegrini, Jean-Louis Teboul…
    Citation: Annals of Intensive Care 2023 13:112
    Content type: Research Published on:

  34. Assessment of the patient’s respiratory effort is essential during assisted ventilation. We aimed to evaluate the accuracy of airway pressure (Paw)-based indices to detect potential injurious inspiratory effort d...

    Authors: Yan-Lin Yang, Yang Liu, Ran Gao, De-Jing Song, Yi-Min Zhou, Ming-Yue Miao, Wei Chen, Shu-Peng Wang, Yue-Fu Wang, Linlin Zhang and Jian-Xin Zhou
    Citation: Annals of Intensive Care 2023 13:111
    Content type: Research Published on:

  35. The release of toxic bile acids (BAs) in the blood of critically ill patients with cholestatic liver dysfunction might lead to the damage of various organs. Their extracorporeal elimination using the cytokine ...

    Authors: Antonia Greimel, Katharina Habler, Caroline Gräfe, Nils Maciuga, Clara Isabell Brozat, Michael Vogeser, Michael Zoller, Felix L. Happich, Uwe Liebchen, Sandra Frank, Michael Paal and Christina Scharf
    Citation: Annals of Intensive Care 2023 13:110
    Content type: Research Published on:

  36. Predictors of ICU-acquired pulmonary aspergillosis (IPA) are not well-established in critically ill patients with ventilator-associated pneumonia (VAP), making IPA commonly misdiagnosed and anti-fungal therapy...

    Authors: Nicolas Massart, Emma Plainfosse, Yanis Benameur, Clarisse Dupin, Florence Legall, Anne Cady, Frederic Gourmelin, François Legay, Nicolas Barbarot, Eric Magalhaes, Pierre Fillatre, Aurélien Frerou and Florian Reizine
    Citation: Annals of Intensive Care 2023 13:109
    Content type: Research Published on:

  37. Data on ventilator associated pneumonia (VAP) in COVID-19 and influenza patients admitted to intensive care units (ICU) are scarce. This study aimed to estimate day-60 mortality related to VAP in ICU patients ...

    Authors: Guillaume Laurichesse, Carole Schwebel, Niccolò Buetti, Mathilde Neuville, Shidasp Siami, Yves Cohen, Virginie Laurent, Bruno Mourvillier, Jean Reignier, Dany Goldgran‐Toledano, Stéphane Ruckly, Etienne de Montmollin, Bertrand Souweine, Jean‐François Timsit and Claire Dupuis
    Citation: Annals of Intensive Care 2023 13:108
    Content type: Research Published on:

  38. Decisions about life-sustaining therapy (LST) in the intensive care unit (ICU) depend on predictions of survival as well as the expected functional capacity and self-perceived quality of life after discharge, ...

    Authors: Michael Beil, Peter Vernon van Heerden, Gavin M. Joynt, Stephen Lapinsky, Hans Flaatten, Bertrand Guidet, Dylan de Lange, Susannah Leaver, Christian Jung, Daniel Neves Forte, Du Bin, Muhammed Elhadi, Wojciech Szczeklik and Sigal Sviri
    Citation: Annals of Intensive Care 2023 13:107
    Content type: Research Published on:

  39. Catheter-related thrombosis (CRT) incidence, rate, and risk factors vary in literature due to differences in populations, catheters, diagnostic methods, and statistical approaches.

    Authors: Chiara Abbruzzese, Amedeo Guzzardella, Dario Consonni, Gloria Turconi, Claudia Bonetti, Matteo Brioni, Mauro Panigada and Giacomo Grasselli
    Citation: Annals of Intensive Care 2023 13:106
    Content type: Research Published on:

  40. The optimal strategy for fluid management during the first few days of ICU in sepsis patients remains controversial. We aimed to investigate the impact of cumulative fluid balance during the first three days o...

    Authors: Dong-gon Hyun, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Younsuck Koh, Dong Kyu Oh, Su Yeon Lee, Mi Hyeon Park, Haein Lee and Chae-Man Lim
    Citation: Annals of Intensive Care 2023 13:105
    Content type: Research Published on:

  41. Prophylactic high-flow nasal cannula (HFNC) oxygen therapy can decrease the risk of extubation failure. It is frequently used in the postextubation phase alone or in combination with noninvasive ventilation. H...

    Authors: Roque Basoalto, L. Felipe Damiani, Yorschua Jalil, María Consuelo Bachmann, Vanessa Oviedo, Leyla Alegría, Emilio Daniel Valenzuela, Maximiliano Rovegno, Pablo Ruiz-Rudolph, Rodrigo Cornejo, Jaime Retamal, Guillermo Bugedo, Arnaud W. Thille and Alejandro Bruhn
    Citation: Annals of Intensive Care 2023 13:104
    Content type: Research Published on:

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:8

    The Letter to the Editor to this article has been published in Annals of Intensive Care 2024 14:7

  42. in COVID-19 acute respiratory failure, the effects of CPAP and FiO2 on respiratory effort and lung stress are unclear. We hypothesize that, in the compliant lungs of early Sars-CoV-2 pneumonia, the application of...

    Authors: Lorenzo Giosa, Patrick Duncan Collins, Martina Sciolla, Francesca Cerrone, Salvatore Di Blasi, Matteo Maria Macrì, Luca Davicco, Andrea Laguzzi, Fabiana Gorgonzola, Roberto Penso, Irene Steinberg, Massimo Muraccini, Alberto Perboni, Vincenzo Russotto, Luigi Camporota, Giacomo Bellani…
    Citation: Annals of Intensive Care 2023 13:103
    Content type: Research Published on:

  43. Understanding the mechanisms underlying immune dysregulation in sepsis is a major challenge in developing more individualized therapy, as early and persistent inflammation, as well as immunosuppression, play a...

    Authors: Muzhda Haem Rahimi, Frank Bidar, Anne-Claire Lukaszewicz, Lorna Garnier, Léa Payen-Gay, Fabienne Venet and Guillaume Monneret
    Citation: Annals of Intensive Care 2023 13:102
    Content type: Research Published on:

  44. Acute respiratory failure (ARF) is the leading cause of ICU admission. Viruses are increasingly recognized as a cause of pneumonia in immunocompromised patients, but epidemiologic data are scarce. We used the Gro...

    Authors: Guillaume Dumas, Maxime Bertrand, Virginie Lemiale, Emmanuel Canet, François Barbier, Achille Kouatchet, Alexandre Demoule, Kada Klouche, Anne-Sophie Moreau, Laurent Argaud, Florent Wallet, Jean-Herlé Raphalen, Djamel Mokart, Fabrice Bruneel, Frédéric Pène and Elie Azoulay
    Citation: Annals of Intensive Care 2023 13:101
    Content type: Research Published on:

  45. Out-of-hospital cardiac arrest (OHCA) is a heterogeneous entity with multiple origins and prognoses. An early, reliable assessment of the prognosis is useful to adapt therapeutic strategy, tailor intensity of ...

    Authors: Jean Baptiste Lascarrou, Wulfran Bougouin, Jonathan Chelly, Jeremy Bourenne, Cedric Daubin, Olivier Lesieur, Pierre Asfar, Gwenhael Colin, Marine Paul, Nicolas Chudeau, Gregoire Muller, Guillaume Geri, Sophier Jacquier, Nicolas Pichon, Thomas Klein, Bertrand Sauneuf…
    Citation: Annals of Intensive Care 2023 13:100
    Content type: Research Published on:

  46. Before the Coronavirus Disease 2019 (COVID-19) pandemic in France, undocumented migrants had a higher risk than general population for being admitted to the intensive care unit (ICU) because of acute respirato...

    Authors: Sami Hraiech, Vanessa Pauly, Véronica Orleans, Pascal Auquier, Elie Azoulay, Antoine Roch, Laurent Boyer and Laurent Papazian
    Citation: Annals of Intensive Care 2023 13:99
    Content type: Research Published on:

  47. Little is known about the performance of the Sequential Organ Failure Assessment (SOFA) score in older critically ill adults. We aimed to evaluate the prognostic impact of physiological disturbances in the six...

    Authors: Kamil Polok, Jakub Fronczek, Zbigniew Putowski, Marcelina Czok, Bertrand Guidet, Christian Jung, Dylan de Lange, Susannah Leaver, Rui Moreno, Hans Flatten and Wojciech Szczeklik
    Citation: Annals of Intensive Care 2023 13:98
    Content type: Research Published on:

  48. The Warburg effect, characterized by elevated lactate levels without tissue hypoxia or shock, has been described in patients with aggressive lymphoproliferative malignancies. However, the clinical characterist...

    Authors: Anis Chaba, Sofiane Fodil, Virginie Lemiale, Eric Mariotte, Sandrine Valade, Elie Azoulay and Lara Zafrani
    Citation: Annals of Intensive Care 2023 13:97
    Content type: Research Published on:

  50. Authors: Bernard Cholley, Mirela Bojan, Benoit Guillon, Emmanuel Besnier, Mathieu Mattei, Bruno Levy, Alexandre Ouattara, Nadir Tafer, Clément Delmas, David Tonon, Bertrand Rozec, Jean-Luc Fellahi, Pascal Lim, François Labaste, François Roubille, Thibaut Caruba…
    Citation: Annals of Intensive Care 2023 13:94
    Content type: Correction Published on:

    The original article was published in Annals of Intensive Care 2023 13:69

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