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  1. Pheochromocytoma, a rare catecholamine-producing tumor, might provoke stress-induced Takotsubo-like cardiomyopathy and severe cardiogenic shock. Because venoarterial-extracorporeal membrane oxygenation (VA-ECM...

    Authors: Guillaume Hekimian, Fatima Kharcha, Nicolas Bréchot, Matthieu Schmidt, Cécile Ghander, Guillaume Lebreton, Xavier Girerd, Christophe Tresallet, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes and Charles-Edouard Luyt
    Citation: Annals of Intensive Care 2016 6:117
  2. Procalcitonin (PCT) is a well-known prognostic marker after elective cardiac surgery. However, the impact of elevated PCT in patients with an initially uneventful postoperative course is still unclear. The aim...

    Authors: Matthias Klingele, Hagen Bomberg, Simone Schuster, Hans-Joachim Schäfers and Heinrich Volker Groesdonk
    Citation: Annals of Intensive Care 2016 6:116
  3. Achieving good glycemic control in intensive care units (ICU) requires a safe and efficient insulin infusion protocol (IIP). We aimed to compare the clinical performance of two IIPs (Leuven versus modified Yal...

    Authors: Christophe E. M. De Block, Peter Rogiers, Philippe G. Jorens, Tom Schepens, Cosimo Scuffi and Luc F. Van Gaal
    Citation: Annals of Intensive Care 2016 6:115
  4. It is unclear whether biomarkers of alveolar damage (surfactant protein D, SPD) or conductive airway damage (club cell secretory protein 16, CC16) measured early after intensive care admittance are associated ...

    Authors: Jens-Ulrik S. Jensen, Theis S. Itenov, Katrin M. Thormar, Lars Hein, Thomas T. Mohr, Mads H. Andersen, Jesper Løken, Hamid Tousi, Bettina Lundgren, Hans Christian Boesen, Maria E. Johansen, Sisse R. Ostrowski, Pär I. Johansson, Jesper Grarup, Jørgen Vestbo and Jens D. Lundgren
    Citation: Annals of Intensive Care 2016 6:114
  5. This study aimed to assess whether a management algorithm using data obtained with a PiCCO system can improve clinical outcomes in critically ill patients with acute respiratory distress syndrome (ARDS).

    Authors: Zhong Yuanbo, Wang Jin, Shi Fei, Long Liangong, Liu Xunfa, Xu Shihai and Shan Aijun
    Citation: Annals of Intensive Care 2016 6:113
  6. Non-occlusive mesenteric ischemia (NOMI) is a common complication and accounts for a major cause of death in critically ill patients. The diagnosis of NOMI with respect to the eventual indications for surgical...

    Authors: Simon Bourcier, Ammar Oudjit, Geoffrey Goudard, Julien Charpentier, Sarah Leblanc, Romain Coriat, Hervé Gouya, Bertrand Dousset, Jean-Paul Mira and Frédéric Pène
    Citation: Annals of Intensive Care 2016 6:112
  7. In patients with acute circulatory failure, the decision to give fluids or not should not be taken lightly. The risk of overzealous fluid administration has been clearly established. Moreover, volume expansion...

    Authors: Xavier Monnet, Paul E. Marik and Jean-Louis Teboul
    Citation: Annals of Intensive Care 2016 6:111
  8. Cytomegalovirus (CMV) infection is increasingly recognized in critically ill immunocompetent patients. Some studies have demonstrated an association between CMV disease and increased mortality rates, prolonged...

    Authors: Awad Al-Omari, Fadi Aljamaan, Waleed Alhazzani, Samer Salih and Yaseen Arabi
    Citation: Annals of Intensive Care 2016 6:110
  9. The aim of this investigation was to compare ventilation at different levels of positive end-expiratory pressure (PEEP) with regard to clinical important outcomes of intensive care unit (ICU) patients without ...

    Authors: Ary Serpa Neto, Roberto Rabello Filho, Thomas Cherpanath, Rogier Determann, Dave A. Dongelmans, Frederique Paulus, Pieter Roel Tuinman, Paolo Pelosi, Marcelo Gama de Abreu and Marcus J. Schultz
    Citation: Annals of Intensive Care 2016 6:109
  10. Sepsis-3 definitions were published recently and validated only in high-income countries. The aim of this study was to assess the new criteria’s accuracy in stratifying mortality as compared to its predecessor...

    Authors: Bruno Adler Maccagnan Pinheiro Besen, Thiago Gomes Romano, Antonio Paulo Nassar Jr., Leandro Utino Taniguchi, Luciano Cesar Pontes Azevedo, Pedro Vitale Mendes, Fernando Godinho Zampieri and Marcelo Park
    Citation: Annals of Intensive Care 2016 6:107
  11. The therapeutic effect of aminoglycosides is highest and optimal when the peak plasma concentration (C max)/minimal inhibitory concentration (MIC) ratio is between 8 and 10. The French ...

    Authors: Nicolas Allou, Astrid Bouteau, Jérôme Allyn, Aurélie Snauwaert, Dorothée Valance, Julien Jabot, Bruno Bouchet, Richard Galliot, Laure Corradi, Philippe Montravers and Pascal Augustin
    Citation: Annals of Intensive Care 2016 6:106
  12. Glucocorticoid-induced leucine zipper (GILZ) is a potent anti-inflammatory protein involved in neutrophil apoptosis and the resolution of inflammation. Given the numerous pathophysiologic roles of neutrophils...

    Authors: Marie-Alix Espinasse, David Hajage, Philippe Montravers, Pascale Piednoir, Guillaume Dufour, Florence Tubach, Vanessa Granger, Luc de Chaisemartin, Benoît Noël, Marc Pallardy, Sylvie Chollet-Martin and Armelle Biola-Vidamment
    Citation: Annals of Intensive Care 2016 6:105
  13. Bloodstream infections (BSI) and delirium are frequent in critically ill patients. During systemic inflammatory response to BSI, cytokines may interact with neurotransmitters and neuronal receptors driving acu...

    Authors: Tolga Dittrich, Sarah Tschudin-Sutter, Andreas F. Widmer, Stephan Rüegg, Stephan Marsch and Raoul Sutter
    Citation: Annals of Intensive Care 2016 6:104
  14. Neuromuscular blockade (NMB) has been shown to improve outcome in acute respiratory distress syndrome (ARDS) in adults, challenging maintaining spontaneous breathing when there is severe lung injury. We tested...

    Authors: Marlon E. F. Wilsterman, Pauline de Jager, Robert Blokpoel, Inez Frerichs, Sandra K. Dijkstra, Marcel J. I. J. Albers, Johannes G. M. Burgerhof, Dick G. Markhorst and Martin C. J. Kneyber
    Citation: Annals of Intensive Care 2016 6:103
  15. Acute respiratory failure (ARF) is the most frequent complication in patients with hematological malignancies and is associated with high morbidity and mortality. ARF etiologies are numerous, and despite exten...

    Authors: Adrien Contejean, Virginie Lemiale, Matthieu Resche-Rigon, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Michael Darmon…
    Citation: Annals of Intensive Care 2016 6:102
  16. Middle East respiratory syndrome coronavirus (MERS-CoV) has caused several hospital outbreaks, including a major outbreak at King Abdulaziz Medical City, a 940-bed tertiary-care hospital in Riyadh, Saudi Arab...

    Authors: Hasan M. Al-Dorzi, Abdulaziz S. Aldawood, Raymond Khan, Salim Baharoon, John D. Alchin, Amal A. Matroud, Sameera M. Al Johany, Hanan H. Balkhy and Yaseen M. Arabi
    Citation: Annals of Intensive Care 2016 6:101
  17. Intra-abdominal hypertension (IAH) is frequently present in critically ill patients and is an independent predictor for mortality. Better recognition of clinically important thresholds is necessary. Increased ...

    Authors: Marije Smit, Maureen J. M. Werner, Annemieke Oude Lansink-Hartgring, Willem Dieperink, Jan G. Zijlstra and Matijs van Meurs
    Citation: Annals of Intensive Care 2016 6:99
  18. Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction...

    Authors: Oliver Karam, Pierre Demaret, Alain Duhamel, Alison Shefler, Philip C. Spinella, Simon J. Stanworth, Marisa Tucci and Stéphane Leteurtre
    Citation: Annals of Intensive Care 2016 6:98
  19. Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described espec...

    Authors: Cécile Aubron, Joris DePuydt, François Belon, Michael Bailey, Matthieu Schmidt, Jayne Sheldrake, Deirdre Murphy, Carlos Scheinkestel, D Jamie Cooper, Gilles Capellier, Vincent Pellegrino, David Pilcher and Zoe McQuilten
    Citation: Annals of Intensive Care 2016 6:97
  20. Over the last several decades, antibacterial drug use has become widespread with their misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have become less effective or even ineffecti...

    Authors: Gabor Zilahi, Antonio Artigas and Ignacio Martin-Loeches
    Citation: Annals of Intensive Care 2016 6:96
  21. Oxidative stress is a key feature of sepsis and could be a common pathophysiological pathway between septic shock and acute kidney injury (AKI) Our objective was to evaluate the erythrocyte superoxide dismuta...

    Authors: Nara Aline Costa, Ana Lúcia Gut, Paula Schmidt Azevedo, Suzana Erico Tanni, Natália Baraldi Cunha, Eloá Siqueira Magalhães, Graziela Biude Silva, Bertha Furlan Polegato, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, André Luís Balbi, Daniela Ponce and Marcos Ferreira Minicucci
    Citation: Annals of Intensive Care 2016 6:95
  22. The prognosis of cirrhotic patients admitted to the ICU is considered to be poor but has been mainly reported in liver ICU. We aimed to describe the prognosis of cirrhotic patients admitted to a general ICU, t...

    Authors: Gaël Piton, Claire Chaignat, Mikhael Giabicani, Jean-Paul Cervoni, Fabienne Tamion, Emmanuel Weiss, Catherine Paugam-Burtz, Gilles Capellier and Vincent Di Martino
    Citation: Annals of Intensive Care 2016 6:94
  23. Despite intermittent control of tracheal cuff pressure (P cuff) using a manual manometer, cuff underinflation (<20 cmH2O) and overinflation (>30 cmH2O) frequently occur in intubated cri...

    Authors: Anahita Rouzé, Julien De Jonckheere, Farid Zerimech, Julien Labreuche, Erika Parmentier-Decrucq, Benoit Voisin, Emmanuelle Jaillette, Patrice Maboudou, Malika Balduyck and Saad Nseir
    Citation: Annals of Intensive Care 2016 6:93
  24. Prior studies of physical functioning after critical illness have been mostly limited to survivors of acute respiratory distress syndrome. The purpose of this study was to objectively assess muscle strength an...

    Authors: Kevin J. Solverson, Christopher Grant and Christopher J. Doig
    Citation: Annals of Intensive Care 2016 6:92
  25. Abnormal chloride levels are commonly observed in critically ill patients, but their clinical relevance remains a matter of debate. We examined the association between abnormal chloremia and ICU and hospital ...

    Authors: Niels Van Regenmortel, Walter Verbrugghe, Tim Van den Wyngaert and Philippe G. Jorens
    Citation: Annals of Intensive Care 2016 6:91
  26. Neutropenia is defined by either an absolute or functional defect (acute myeloid leukemia or myelodysplastic syndrome) of polymorphonuclear neutrophils and is associated with high risk of specific complication...

    Authors: David Schnell, Elie Azoulay, Dominique Benoit, Benjamin Clouzeau, Pierre Demaret, Stéphane Ducassou, Pierre Frange, Matthieu Lafaurie, Matthieu Legrand, Anne-Pascale Meert, Djamel Mokart, Jérôme Naudin, Frédéric Pene, Antoine Rabbat, Emmanuel Raffoux, Patricia Ribaud…
    Citation: Annals of Intensive Care 2016 6:90
  27. A recently developed prediction score based on age, arterial oxygen partial pressure to fractional inspired oxygen ratio (PaO2/FiO2) and plateau pressure (abbreviated as ‘APPS’) was shown to accurately predict mo...

    Authors: Lieuwe D. Bos, Laura R. Schouten, Olaf L. Cremer, David S. Y. Ong and Marcus J. Schultz
    Citation: Annals of Intensive Care 2016 6:89
  28. Computed tomography angiography (CTA) is largely performed in European countries as an ancillary test for diagnosing brain death. However, CTA suffers from a lack of sensitivity, especially in patients who hav...

    Authors: Antoine J. Marchand, Philippe Seguin, Yannick Malledant, Marion Taleb, Hélène Raoult and Jean Yves Gauvrit
    Citation: Annals of Intensive Care 2016 6:88
  29. Impact of early systemic hemodynamic alterations and fluid resuscitation on outcome in the modern burn care remains controversial. We investigate the association between acute-phase systemic hemodynamics, timi...

    Authors: Sabri Soussi, Benjamin Deniau, Axelle Ferry, Charlotte Levé, Mourad Benyamina, Véronique Maurel, Maïté Chaussard, Brigitte Le Cam, Alice Blet, Maurice Mimoun, Jêrome Lambert, Marc Chaouat, Alexandre Mebazaa and Matthieu Legrand
    Citation: Annals of Intensive Care 2016 6:87
  30. Delirium is a frequently occurring syndrome in patients admitted to the intensive care unit (ICU) or medium care unit (MCU), yet the pathophysiology remains poorly understood. An excess of central serotonin ca...

    Authors: Catharina E. van Ewijk, Gabriel E. Jacobs and Armand R. J. Girbes
    Citation: Annals of Intensive Care 2016 6:85
  31. High-frequency oscillatory ventilation (HFOV) has not been shown to be beneficial in the management of moderate-to-severe acute respiratory distress syndrome (ARDS). There is uncertainty about the actual pres...

    Authors: Christophe Guervilly, Jean-Marie Forel, Sami Hraiech, Antoine Roch, Daniel Talmor and Laurent Papazian
    Citation: Annals of Intensive Care 2016 6:84
  32. Different video-laryngoscopes (VDLs) for endotracheal intubation (ETI) have recently been developed. We compared the performance of the VDL Airway Scope (AWS) with the direct laryngoscopy by Macintosh (DLM) fo...

    Authors: Pierre-Louis Declercq, Michael Bubenheim, Stéphanie Gelinotte, Kévin Guernon, Jean-Baptiste Michot, Vincent Royon, Dorothée Carpentier, Gaëtan Béduneau, Fabienne Tamion and Christophe Girault
    Citation: Annals of Intensive Care 2016 6:83
  33. The relatives of intensive care unit (ICU) patients must cope with both the severity of illness of their loved one and the unfamiliar and stressful ICU environment. This hardship may lead to post-intensive car...

    Authors: Maité Garrouste-Orgeas, Isabelle Vinatier, Alexis Tabah, Benoit Misset and Jean-François Timsit
    Citation: Annals of Intensive Care 2016 6:82
  34. End-inspiratory pause (EIP) prolongation decreases dead space-to-tidal volume ratio (Vd/Vt) and PaCO2. We do not know the physiological benefits of this approach to improve respiratory system mechanics in acute r...

    Authors: Hernan Aguirre-Bermeo, Indalecio Morán, Maurizio Bottiroli, Stefano Italiano, Francisco José Parrilla, Eugenia Plazolles, Ferran Roche-Campo and Jordi Mancebo
    Citation: Annals of Intensive Care 2016 6:81
  35. Early mobilization in critically ill patients has been shown to prevent bed-rest-associated morbidity. Reported reasons for not mobilizing patients, thereby excluding or delaying such intervention, are diverse...

    Authors: Cheryl Elizabeth Hickmann, Diego Castanares-Zapatero, Emilie Bialais, Jonathan Dugernier, Antoine Tordeur, Lise Colmant, Xavier Wittebole, Giuseppe Tirone, Jean Roeseler and Pierre-François Laterre
    Citation: Annals of Intensive Care 2016 6:80
  36. Authors: João M. Silva Jr., Helder Marcus Costa Rocha, Henrique Tadashi Katayama, Leandro Ferreira Dias, Mateus Barros de Paula, Leusi Magda Romano Andraus, Jose Maria Correa Silva and Luiz Marcelo Sá Malbouisson
    Citation: Annals of Intensive Care 2016 6:78

    The original article was published in Annals of Intensive Care 2016 6:42

  37. In 2010, the EUPHAS 2 collaborative group created a registry with the purpose of recording data from critically ill patients suffering from severe sepsis and septic shock treated with polymyxin-B hemoperfusion...

    Authors: Salvatore Lucio Cutuli, Antonio Artigas, Roberto Fumagalli, Gianpaola Monti, Vito Marco Ranieri, Claudio Ronco and Massimo Antonelli
    Citation: Annals of Intensive Care 2016 6:77
  38. The ultrasound (US)-guided technique has been recommended for central venous catheter (CVC) placement in critical care. However, several surveys have shown that the majority of physicians continue to perform l...

    Authors: Julien Maizel, Marie-Anaïs Bastide, Jack Richecoeur, Eric Frenoy, Christian Lemaire, Bertrand Sauneuf, Hervé Dupont, Fabienne Tamion, Saad Nseir and Damien Du Cheyron
    Citation: Annals of Intensive Care 2016 6:76
  39. In intensive care unit (ICU) patients, diaphragmatic dysfunction (DD) can occur on admission or during the subsequent stay. The respective incidence of these two phenomena has not been previously studied in hu...

    Authors: Alexandre Demoule, Nicolas Molinari, Boris Jung, Hélène Prodanovic, Gerald Chanques, Stefan Matecki, Julien Mayaux, Thomas Similowski and Samir Jaber
    Citation: Annals of Intensive Care 2016 6:75
  40. The benefit of ICU admission for elderly patients remains controversial. This report highlights the methodology, the feasibility of and the ethical and logistical constraints in designing and conducting a clu...

    Authors: Ariane Boumendil, Maguy Woimant, Jean-Pierre Quenot, François-Xavier Rooryck, Foued Makhlouf, Youri Yordanov, Samuel Delerme, Khalil Takun, Patrick Ray, Marie-Clément Kouka, Claire Poly, Maité Garrouste-Orgeas, Caroline Thomas, Tabasome Simon, Sylvie Azerad, Guillaume Leblanc…
    Citation: Annals of Intensive Care 2016 6:74
  41. Volume-controlled ventilation has been suggested to optimize lung deposition during nebulization although promoting spontaneous ventilation is targeted to avoid ventilator-induced diaphragmatic dysfunction. Co...

    Authors: Jonathan Dugernier, Gregory Reychler, Xavier Wittebole, Jean Roeseler, Virginie Depoortere, Thierry Sottiaux, Jean-Bernard Michotte, Rita Vanbever, Thierry Dugernier, Pierre Goffette, Marie-Agnes Docquier, Christian Raftopoulos, Philippe Hantson, François Jamar and Pierre-François Laterre
    Citation: Annals of Intensive Care 2016 6:73
  42. Although the loop-diuretic furosemide is widely employed in critically ill patients with known long-term effects on plasma electrolytes, accurate data describing its acute effects on renal electrolyte handling...

    Authors: Luca Zazzeron, Davide Ottolina, Eleonora Scotti, Michele Ferrari, Paola Bruzzone, Silvio Sibilla, Cristina Marenghi, Luciano Gattinoni and Pietro Caironi
    Citation: Annals of Intensive Care 2016 6:72
  43. In acute kidney injury (AKI), useless continuation of renal replacement therapy (RRT) may delay renal recovery and impair patient’s outcome. In this study, we aimed to identify predictive parameters that may h...

    Authors: Nicolas Viallet, Vincent Brunot, Nils Kuster, Delphine Daubin, Noémie Besnard, Laura Platon, Aurèle Buzançais, Romaric Larcher, Olivier Jonquet and Kada Klouche
    Citation: Annals of Intensive Care 2016 6:71
  44. Continuous glucose monitoring (CGM) has not yet been implemented in the intensive care unit (ICU) setting. The purpose of this study was to evaluate reliability, feasibility, nurse acceptance and accuracy of t...

    Authors: Tobias Wollersheim, Lilian Jo Engelhardt, Jeanne Pachulla, Rudolf Moergeli, Susanne Koch, Claudia Spies, Michael Hiesmayr and Steffen Weber-Carstens
    Citation: Annals of Intensive Care 2016 6:70
  45. Prolonged mechanical ventilation for acute medical conditions increases the risk of chronic critical illness (CCI). Close family members are confronted with the life-threatening condition of the CCI patients ...

    Authors: Gloria-Beatrice Wintermann, Kerstin Weidner, Bernhard Strauß, Jenny Rosendahl and Katja Petrowski
    Citation: Annals of Intensive Care 2016 6:69
  46. Microdialysis is a well-established technology that can be used for continuous blood glucose monitoring. We determined point and trend accuracy, and reliability of a microdialysis-based continuous blood glucos...

    Authors: J. H. Leopold, R. T. M. van Hooijdonk, M. Boshuizen, T. Winters, L. D. Bos, A. Abu-Hanna, A. M. T. Hoek, J. C. Fischer, E. C. van Dongen-Lases and M. J. Schultz
    Citation: Annals of Intensive Care 2016 6:68

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