Figure 6From: Ventilator-induced lung injury: historical perspectives and clinical implications Effect of increasing PEEP from 0 to 15 cm H 2 O during ventilation with two levels of tidal volume (V T , 7 ml/kg of body weight = Lo V T ; 14 ml/kg BW of body weight = Med V T ). When PEEP was increased, pulmonary edema, as evaluated by extravascular lung water (Qwl), occurred. The level of PEEP required to produce edema varied with VT; 15 cm H2O PEEP during ventilation with a low VT versus 10 cm H2O PEEP during ventilation with a moderately increased VT. *p < 0.05; **p < 0.01 vs. ZEEP and the same VT. Used with permission. From Dreyfuss and Saumon [33].Back to article page