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  1. Research

    Moral distress and its contribution to the development of burnout syndrome among critical care providers

    Burnout appears to be common among critical care providers. It is characterized by three components: emotional exhaustion, depersonalization and personal accomplishment. Moral distress is the inability of a mo...

    Renata Rego Lins Fumis, Gustavo Adolpho Junqueira Amarante, Andréia de Fátima Nascimento and José Mauro Vieira Junior

    Annals of Intensive Care 2017 7:71

    Published on: 21 June 2017

  2. Research

    Etiologies, diagnostic work-up and outcomes of acute respiratory distress syndrome with no common risk factor: a prospective multicenter study

    Patients meeting the Berlin definition for the acute respiratory distress syndrome (ARDS) might lack exposure to one or more “common” risk factors and exhibit different clinical phenotype and outcomes. We aime...

    Nicolas de Prost, Tài Pham, Guillaume Carteaux, Armand Mekontso Dessap, Christian Brun-Buisson, Eddy Fan, Giacomo Bellani, John Laffey, Alain Mercat, Laurent Brochard and Bernard Maître

    Annals of Intensive Care 2017 7:69

    Published on: 19 June 2017

  3. Review

    Targeted temperature management in the ICU: guidelines from a French expert panel

    Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term “targeted temperature management” (TTM) h...

    Alain Cariou, Jean-François Payen, Karim Asehnoune, Gerard Audibert, Astrid Botte, Olivier Brissaud, Guillaume Debaty, Sandrine Deltour, Nicolas Deye, Nicolas Engrand, Gilles Francony, Stéphane Legriel, Bruno Levy, Philippe Meyer, Jean-Christophe Orban, Sylvain Renolleau…

    Annals of Intensive Care 2017 7:70

    Published on: 19 June 2017

  4. Research

    Systemic antibiotics for preventing ventilator-associated pneumonia in comatose patients: a systematic review and meta-analysis

    Early-onset ventilator-associated pneumonia (EO-VAP) is the leading cause of morbidity and mortality in comatose patients. However, VAP prevention bundles focus mainly on late-onset VAP and may be less effecti...

    Cássia Righy, Pedro Emmanuel Americano do Brasil, Jordi Vallés, Fernando A. Bozza and Ignacio Martin-Loeches

    Annals of Intensive Care 2017 7:67

    Published on: 15 June 2017

  5. Research

    Assessment of renal hemodynamic toxicity of fluid challenge with 0.9% NaCl compared to balanced crystalloid (PlasmaLyte®) in a rat model with severe sepsis

    According to international guidelines, volume expansion with crystalloids is the first-line treatment for hemodynamic management in patients with severe sepsis or septic shock. Compared to balanced crystalloid...

    Pierre-Yves Olivier, François Beloncle, Valérie Seegers, Maher Tabka, Mathilde Renou de La Bourdonnaye, Alain Mercat, Paul Cales, Daniel Henrion, Peter Radermacher, Lise Piquilloud, Nicolas Lerolle and Pierre Asfar

    Annals of Intensive Care 2017 7:66

    Published on: 14 June 2017

  6. Research

    Frequency, associated factors and outcome of multi-drug-resistant intensive care unit-acquired pneumonia among patients colonized with extended-spectrum β-lactamase-producing Enterobacteriaceae

    We assessed prevalence, associated factors and prognosis of extended-spectrum beta-lactamase-producing Enterobacteriaceae pneumonia acquired in intensive care unit (ESBL-PE pneumonia) among carriers. Variable...

    Keyvan Razazi, Armand Mekontso Dessap, Guillaume Carteaux, Chloé Jansen, Jean-Winoc Decousser, Nicolas de Prost and Christian Brun-Buisson

    Annals of Intensive Care 2017 7:61

    Published on: 12 June 2017

  7. Research

    Venoarterial PCO2-to-arteriovenous oxygen content difference ratio is a poor surrogate for anaerobic metabolism in hemodilution: an experimental study

    The identification of anaerobic metabolism in critically ill patients is a challenging task. Observational studies have suggested that the ratio of venoarterial PCO2 (Pv–aCO2) to arteriovenous oxygen content diff...

    Arnaldo Dubin, Gonzalo Ferrara, Vanina Siham Kanoore Edul, Enrique Martins, Héctor Saúl Canales, Carlos Canullán, Gastón Murias, Mario Omar Pozo and Elisa Estenssoro

    Annals of Intensive Care 2017 7:65

    Published on: 12 June 2017

  8. Research

    Red blood cell transfusion in the resuscitation of septic patients with hematological malignancies

    Indications for red blood cell (RBC) transfusion in septic acute circulatory failure remain unclear. We addressed the practices and the prognostic impact of RBC transfusion in the early resuscitation of severe...

    Adrien Mirouse, Matthieu Resche-Rigon, Virginie Lemiale, Djamel Mokart, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne Renault, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar…

    Annals of Intensive Care 2017 7:62

    Published on: 12 June 2017

  9. Research

    Early impairment of intracranial conduction time predicts mortality in deeply sedated critically ill patients: a prospective observational pilot study

    Somatosensory (SSEP) and brainstem auditory (BAEP) evoked potentials are neurophysiological tools which, respectively, explore the intracranial conduction time (ICCT) and the intrapontine conduction time (IPCT...

    Eric Azabou, Benjamin Rohaut, Nicholas Heming, Eric Magalhaes, Régine Morizot-Koutlidis, Stanislas Kandelman, Jeremy Allary, Guy Moneger, Andrea Polito, Virginie Maxime, Djillali Annane, Frederic Lofaso, Fabrice Chrétien, Jean Mantz, Raphael Porcher and Tarek Sharshar

    Annals of Intensive Care 2017 7:63

    Published on: 12 June 2017

  10. Research

    Can proportional ventilation modes facilitate exercise in critically ill patients? A physiological cross-over study

    Early exercise of critically ill patients may have beneficial effects on muscle strength, mass and systemic inflammation. During pressure support ventilation (PSV), a mismatch between demand and assist could i...

    Evangelia Akoumianaki, Nicolas Dousse, Aissam Lyazidi, Jean-Claude Lefebvre, Severine Graf, Ricardo Luiz Cordioli, Nathalie Rey, Jean-Christophe Marie Richard and Laurent Brochard

    Annals of Intensive Care 2017 7:64

    Published on: 12 June 2017

  11. Review

    Noninvasive ventilation with helium–oxygen mixture in hypercapnic COPD exacerbation: aggregate meta-analysis of randomized controlled trials

    When used as a driving gas during NIV in hypercapnic COPD exacerbation, a helium–oxygen (He/O2) mixture reduces the work of breathing and gas trapping. The potential for He/O2 to reduce the rate of NIV failure le...

    Fekri Abroug, Lamia Ouanes-Besbes, Zeineb Hammouda, Saoussen Benabidallah, Fahmi Dachraoui, Islem Ouanes and Philippe Jolliet

    Annals of Intensive Care 2017 7:59

    Published on: 6 June 2017

  12. Research

    Low HDL levels in sepsis versus trauma patients in intensive care unit

    The protective cardiovascular effect of high-density lipoproteins (HDLs) is considered to chiefly rely on reverse cholesterol transport from peripheral tissues back to the liver. However, HDL particles display...

    Sébastien Tanaka, Julien Labreuche, Elodie Drumez, Anatole Harrois, Sophie Hamada, Bernard Vigué, David Couret, Jacques Duranteau and Olivier Meilhac

    Annals of Intensive Care 2017 7:60

    Published on: 6 June 2017

  13. Research

    Omega-3 supplementation in patients with sepsis: a systematic review and meta-analysis of randomized trials

    Nutritional supplementation of omega-3 fatty acids has been proposed to modulate the balance of pro- and anti-inflammatory mediators in sepsis. If proved to improve clinical outcomes in critically ill patients...

    Clara Lu, Sunjay Sharma, Lauralyn McIntyre, Andrew Rhodes, Laura Evans, Saleh Almenawer, Lori Leduc, Derek C. Angus and Waleed Alhazzani

    Annals of Intensive Care 2017 7:58

    Published on: 5 June 2017

  14. Research

    The impact of a multifaceted intervention including sepsis electronic alert system and sepsis response team on the outcomes of patients with sepsis and septic shock

    Compliance with the clinical practice guidelines of sepsis management has been low. The objective of our study was to describe the results of implementing a multifaceted intervention including an electronic al...

    Yaseen M. Arabi, Hasan M. Al-Dorzi, Ahmed Alamry, Ra’ed Hijazi, Sami Alsolamy, Majid Al Salamah, Hani M. Tamim, Saad Al-Qahtani, Abdulaziz Al-Dawood, Abdellatif M. Marini, Fatimah H. Al Ehnidi, Shihab Mundekkadan, Amal Matroud, Mohamed S. Mohamed and Saadi Taher

    Annals of Intensive Care 2017 7:57

    Published on: 30 May 2017

  15. Research

    Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study

    Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of ox...

    Jingyuan Xu, Xiao Peng, Chun Pan, Shixia Cai, Xiwen Zhang, Ming Xue, Yi Yang and Haibo Qiu

    Annals of Intensive Care 2017 7:56

    Published on: 23 May 2017

  16. Research article

    Nasal high flow in management of children with status asthmaticus: a retrospective observational study

    Asthma is the most common obstructive airway disease in children and adults. Nasal high flow (NHF) is a recent device that is now used as a primary support for respiratory distress. Several studies have report...

    Florent Baudin, Alexandra Buisson, Blandine Vanel, Bruno Massenavette, Robin Pouyau and Etienne Javouhey

    Annals of Intensive Care 2017 7:55

    Published on: 22 May 2017

  17. Research

    Functional outcome of patients with prolonged hypoglycemic encephalopathy

    Little is known about the causes, clinical course and long-term outcome of comatose patients with prolonged hypoglycemic encephalopathy.

    Guillaume Barbara, Bruno Mégarbane, Laurent Argaud, Guillaume Louis, Nicolas Lerolle, Francis Schneider, Stéphane Gaudry, Nicolas Barbarot, Angéline Jamet, Hervé Outin, Sébastien Gibot and Pierre-Edouard Bollaert

    Annals of Intensive Care 2017 7:54

    Published on: 22 May 2017

  18. Research

    External validation of SAPS 3 and MPM0-III scores in 48,816 patients from 72 Brazilian ICUs

    The performance of severity-of-illness scores varies in different scenarios and must be validated prior of being used in a specific settings and geographic regions. Moreover, models’ calibration may deteriorat...

    Giulliana Martines Moralez, Ligia Sarmet Cunha Farah Rabello, Thiago Costa Lisboa, Mariza da Fonte Andrade Lima, Rodrigo Marques Hatum, Fernando Vinicius Cesar De Marco, Alessandra Alves, Jorge Eduardo da Silva Soares Pinto, Hélia Beatriz Nunes de Araújo, Grazielle Viana Ramos, Aline Reis Silva, Guilherme Côrtes Fernandes, Guilherme Brenande Alves Faria, Ciro Leite Mendes, Roberto Álvaro Ramos Filho, Valdênia Pereira de Souza…

    Annals of Intensive Care 2017 7:53

    Published on: 18 May 2017

  19. Research

    The effect of insulin administration on c-peptide in critically ill patients with type 2 diabetes

    In critically ill patients with permissive hyperglycemia, it is uncertain whether exogenous insulin administration suppresses or enhances c-peptide secretion (a marker of pancreatic beta-cell response). We aim...

    Marco Crisman, Luca Lucchetta, Nora Luethi, Luca Cioccari, Que Lam, Glenn M. Eastwood, Rinaldo Bellomo and Johan Mårtensson

    Annals of Intensive Care 2017 7:50

    Published on: 12 May 2017

  20. Review

    Systematic review and meta-analysis of complications and mortality of veno-venous extracorporeal membrane oxygenation for refractory acute respiratory distress syndrome

    Veno-venous extracorporeal membrane oxygenation (ECMO) for refractory acute respiratory distress syndrome (ARDS) is a rapidly expanding technique. We performed a systematic review and meta-analysis of the most...

    Sergi Vaquer, Candelaria de Haro, Paula Peruga, Joan Carles Oliva and Antonio Artigas

    Annals of Intensive Care 2017 7:51

    Published on: 12 May 2017

  21. Review

    Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference

    The French Intensive Care Society organized its yearly Paris International Conference in intensive care on June 18–19, 2015. The main purpose of this meeting is to gather the best experts in the field in order...

    Rinaldo Bellomo, Claudio Ronco, Ravindra L. Mehta, Pierre Asfar, Julie Boisramé-Helms, Michael Darmon, Jean-Luc Diehl, Jacques Duranteau, Eric A. J. Hoste, Joannes-Boyau Olivier, Matthieu Legrand, Nicolas Lerolle, Manu L. N. G. Malbrain, Johan Mårtensson, Heleen M. Oudemans-van Straaten, Jean-Jacques Parienti…

    Annals of Intensive Care 2017 7:49

    Published on: 4 May 2017

  22. Research

    High-flow nasal cannula to prevent postextubation respiratory failure in high-risk non-hypercapnic patients: a randomized multicenter trial

    Extubation failure is associated with increased morbidity and mortality, but cannot be safely predicted or avoided. High-flow nasal cannula (HFNC) prevents postextubation respiratory failure in low-risk patients.

    Rafael Fernandez, Carles Subira, Fernando Frutos-Vivar, Gemma Rialp, Cesar Laborda, Joan Ramon Masclans, Amanda Lesmes, Luna Panadero and Gonzalo Hernandez

    Annals of Intensive Care 2017 7:47

    Published on: 2 May 2017

  23. Research

    Are high nurse workload/staffing ratios associated with decreased survival in critically ill patients? A cohort study

    Despite the central role of nurses in intensive care, a relationship between intensive care nurse workload/staffing ratios and survival has not been clearly established. We determined whether there is a thresh...

    Anna Lee, Yip Sing Leo Cheung, Gavin Matthew Joynt, Czarina Chi Hung Leung, Wai-Tat Wong and Charles David Gomersall

    Annals of Intensive Care 2017 7:46

    Published on: 2 May 2017

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