Table 1 Sources and biological effect of investigated inflammatory mediators
Inflammatory mediator | Abbreviation | Major cell sources | Major activity |
|---|---|---|---|
Interleukin 6 | IL-6 | T cells, macrophages | Mediator of fever and acute phase response. Has both pro- and anti-inflammatory properties |
Interleukin 8 | IL-8 | Macrophages, epithelium, endothelium | Mediator inflammatory response. Chemotactic mainly for neutrophils |
Interleukin 10 | IL-10 | Monocytes, lymphocytes | Anti-inflammatory, inhibits synthesis various pro-inflammatory cytokines |
Intercellular adhesion molecule 1 | ICAM-1 | Leucocytes, endothelium | Facilitates leucocyte endothelial transmigration, signal transduction pro-inflammatory pathways |
Monocyte chemoattractant protein 1 | MCP-1 | Monocytes, endothelium, smooth muscle cells | Chemotactic mainly for monocytes |
Tissue factor | TF | Subendothelial tissue, platelets, leucocytes | Initiation coagulation cascade, intracellular signalling (angiogenesis, apoptosis) |
Cluster of differentiation molecule 11b | CD11b | Monocytes, neutrophils, macrophages, natural killer cells | Regulates leucocyte adhesion and migration, implicated in phagocytosis and cell mediated cytotoxicity |
L-selectin | L-selectin | Leucocytes | Adhesion and homing receptor for leucocytes to enter secondary lymphoid tissues |
Matrix metalloproteinase 9 | MMP9 | Macrophages, neutrophils, endothelium | Breakdown extracellular matrix, invasion of inflammatory cells |
β2 microglobulin |  |  | Housekeeping gene |