Cisatracurium | Control | p value | SMD / RR | Heterogeneity | p value | |
---|---|---|---|---|---|---|
(n= 223) | (n= 208) | (95% Confidence Interval) | ||||
Age, years | 56.60 ± 4.08 | 60.16 ± 1.89 | 0.300** | |||
Lung injury score | 2.94 ± 0.07 | 2.86 ± 0.09 | 0.667** | |||
SAPS II | 46.26 ± 4.14 | 47.13 ± 1.80 | 0.999** | |||
Onset of ARDS, days | 0.90 ± 0.13 | 0.98 ± 0.31 | 0.700** | |||
Days receiving mechanical ventilation | 1.80 ± 1.26 | 2.13 ± 1.78 | 0.667** | |||
Change in PaO2 / FiO2 * | 93.66 ± 40.12 | 42.66 ± 4.04 | 0.050** | SMD: 0.29 (0.09 – 0.49)¶ | 0.320 | 0.004 |
Change in PaCO2 *, mmHg | 8.76 ± 27.1 | 10.66 ± 23.80 | 0.150** | SMD: 0.02 (-0.17 – 0.21) ¶ | 0.520 | 0.800 |
Change in PEEP*, cmH2O | - 2.20 ± 1.90 | - 0.46 ± 0.56 | 0.050** | SMD: -0.18 (-0.37 – 0.01) ¶ | 0.430 | 0.060 |
Change in VT *, mL/kg | 0.28 ± 0.33 | 0.30 ± 0.11 | 0.150** | SMD: -0.02 (-0.21 – 0.17) ¶ | 0.300 | 0.850 |
Change in FiO2 *, % | - 25.40 ± 7.91 | - 13.10 ± 7.39 | 0.050** | SMD: -0.31 (-0.50 – -0.12) ¶ | 0.260 | 0.002 |
Change in Plateau Pressure*, cmH2O | - 3.66 ± 1.49 | - 0.70 ± 0.60 | 0.050** | SMD: -0.11 (-0.30 – 0.08) ¶ | 0.040 | 0.250 |
Ventilator-free days at day 28, days | 6.76 ± 3.51 | 5.20 ± 3.40 | SMD: 0.22 (0.03 – 0.41) | 0.860 | 0.020 | |
Barotrauma, n (%) | 9 (4.0) | 20 (9.6) | RR: 0.45 (0.22 – 0.92) | 0.830 | 0.030 | |
Critical illness neuromyopathy, n (%) | 41 (18.3) | 29 (13.9) | RR: 1.13 (0.76 – 1.66) | 0.990 | 0.550 | |
ICU mortality, n (%) | 70 (31.4) | 93 (44.7) | RR: 0.71 (0.55 – 0.90) | 0.620 | 0.005 | |
Mortality at day 28 after inclusion, n (%) | 52 (23.3) | 71 (34.1) | RR: 0.68 (0.51 – 0.92) | 0.580 | 0.010 |