Antibiotic | Patients | Dose | Vd (l/kg) | CL (ml/min) | T ½(h) | C max(mg/ml) | AUC (mg·h/L) | MIC targeted (mg/L) | PD target achieved | Reference |
---|---|---|---|---|---|---|---|---|---|---|
Cefepime | 12 | 2 g q12h | 0.34* | 123 | 3.2 | 346 | 4 | 77% T > MIC | [18] | |
19 | 2 g q8h | 0.36 | 88.2* | 3.37 | 68 | 310 | 32 | 34% T > 4xMIC | [20] | |
13 | 2 g q12h | 0.32* | 134 | 2.5 | 249 | [33] | ||||
7 | 2 g q12h | 0.47* | 125 | 3.42 | 305 | 7 | 80% T > MIC90 | [19] | ||
5 | 100% T > MIC90 | |||||||||
17 | 2 g q8h | 0.37 | 88.2* | 3.37 | 66.56 | 324.02 | [34] | |||
Ceftazidime | 15 | 2 g q8h | 0.81* | 151 | 4.75 | 277.31 | [21] | |||
12 | 2 g q8h | 0.27* | 3.48 | 124.4 | 331 | 4 | 92% T > MIC | [35] | ||
17 | 2 g q8h | 0.51 | 63.7* | 6.28 | 61.65 | 523.49 | [34] | |||
18 | 2 g q8h | 0.48 | 112* | 5.84 | 63 | 522 | 32 | 45% T > 4xMIC | [20] | |
10 | 2 g q8h | 0.23 | 112* | 1.98 | [36] | |||||
49 | 2 g q8h or 6 g CI/day | 0.67* | 91.3 | [22] | ||||||
Meropenem | 8 | 2 g q8h or | 0.38* | 156.7 | 2.4 | 110.1 | 193.8 | 100% T > MIC | [37] | |
7 | 2 g LD + 3 g CI/day | 0.37* | 128.3 | 117.5 | 100% T > MIC | |||||
16 | 1 g q8h | 0.43 | 130.9* | 2.05 | 35 | 132 | 8 | 57% T > 4xMIC | [20] | |
10 | 1 g q8h or 3 g CI/day | 0.32* | 226.7 | [23] | ||||||
10 | 1 g q8h | 0.39* | 191 | 2.13 | 46.6 | 99.5 | 0.25-1 | 100% T > MIC | [38] | |
Piperacillin | 8 | 12/1.5 g PIP/TAZ CI | 0.33 | 286.7 | 144 | [24] | ||||
8 | 4/0.5 PIP/TAZ q6h or q8h | 266.6 | ||||||||
27 | 4 g q6h | 0.38 | 141.4* | 2.58 | 123 | 469 | 64 | 33% T > 4xMIC | [20] | |
Ceftriaxone | 54 | 2 g qd | 0.28* | 14.7 | 9.6 | 8 | 16% T > MIC | [25] | ||
10 | 2 g qd | 0.28* | 41.3 | 6.4 | 204.9 | [30] | ||||
Ertapenem | 17 | 1 g CI/day | 0.21* | 43.2 | 4.15 | 90 | 418 | 2 | 25% T > MIC | [39] |
8 | 1 g qd | 0.85* | 200.5 | 5.7 | 94.1 | 317.7 | [26] | |||
Flucloxacillin | 10 | 0.29* | 150.2 | 2.45 | [27] |