Benefits of an early cooling phase in continuous renal replacement therapy for ICU patients

Annals of Intensive Care

Table 3 Hemodynamic variations and therapeutic interventions from H7 to H12

	Group A				Group B				Pintergroup
	Period 2 Temp 36°C				Period 2 Temp 38°C
	n = 11				n = 11
	H7	H12	H12-H6	P Intra- group	H7	H12	H12-H7	P Intra- group	H12-H7
SAP mmHg	124 [21]	125 [18]	1.1 [21.1]	0.66	121 [27]	122 [25]	1.5[12.8]	0.48	0.07
DAP mmHg	62 [12]	58 [10]	−3.5 [10.7]	0.45	60 [5]	64 [10]	3.7 [10]	0.18	0.16
MAP mmHg	79 [15]	79 [11]	−0.9 [12.3]	0.88	80 [10]	83 [13]	2.5 [9.9]	0.33	0.53
HR beat/min	88 [16]	89 [12]	1.4 [12.3]	0.99	105 [23]	102 [23]	−2.8 [6.4]	0.2	0.69
Lactates (mmol/L)	4.9 [5.7]	5.6 [6.8]	0.6 [1.4]	0.33	2.2 [1.6]	2.4 [1.9]	0.2 [0.3]	0.21	0.64
Nep dosage μg/kg/min	0.76 [1.01]	0.81 [1.13]	0.05 [0.3]	0.89	0.64 [0.58]	0.66 [0.63]	−0.02 [0.1]	0.67	0.99
Increase of CA dose (no. patients)	2				4
Decrease of CA dose (no. patients)	4				2
Fluid infusion (n of patients)	3				0
Total volume infused (ml)	3500				0
Therapeutic action (no. patients)	3				4

Values are expressed as mean [SD] or median (interquartile range); SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, CA catecholamine, Nep norepinephrine. Therapeutic action: fluid infusion or increase dosage of catecholamine.