Table 1 Definition of biomarkers and subtypes according to the national institute of health[1]
Denomination | Definition |
|---|---|
Biomarker | Biological characteristics objectively measured, and used as a marker either of a normal or pathological biological pathway, or of a pharmacological response to a specific intervention |
Biomarker type 0 | Biological maker of the disease course, linked to a recognised clinical variable |
Biomarker type I | Biological marker reflecting the effects of a therapy, and linked to its mechanism of action |
Biomarker type II | Biological marker used as a surrogate endpoint, where changes in the biomarker levels are associated to a clinical benefit or to an increased risk. |