Table 2 Weaning from extracorporeal membrane oxygenation (ECMO)

Venovenous ECMO

F_ECO₂ = 21%

Pplat < 25 to 30 cmH₂O with TV around 6 ml/kg and PEEP < 12 cmH₂O

Sweep gas flow 1 L/minute or stopped

and PaO₂ > 70 mmHg on FiO₂ < 60% or PaO₂/FiO₂ > 200 mmHg

Duration: several hours

and pH > 7.3 with PCO₂ < 50 mmHg

and no acute cor pulmonale

Arteriovenous ECMO

F_ECO₂ = 21%

Pplat < 25 to 30 cmH₂O with TV around 6 ml/kg and PEEP < 12 cmH₂O

Sweep gas flow 1 L/minute

and PaO₂ > 70 mmHg on FiO₂ < 60% or PaO₂/FiO₂ > 200 mmHg

Reduce pump blood flow by steps of 0.5 L/minute

and pH > 7.3 with PCO₂ < 50 mmHg

Duration: several hours

and no acute cor pulmonale

without left ventricular failure:

left ventricular ejection fraction > 25 to 30%

velocity-time integral > 12 cm