Anemia and red blood cell transfusion in critically ill cardiac patients

Annals of Intensive Care

Table 1 Anemia and outcomes in cardiac adults: observations studies

	Health problem	Patients	Studies	Risk
Outcome		(n)	(n)	(95% CI)
Meta-analyses
Mortality^a[14]	ACS	51,449	10	aOR: 1.49 (1.24 to 1.79)
Mortality^b[9]	ACS	171,915	27	aHR: 1.49 (1.23 to 1.81)
Studies not included in the meta-analyses
Mortality [15]	New heart failure	12,065	1	aHR: 1.34 (1.24 to 1.46)
Mortality [16]	PCI	6,116	1	aHR: 1.8 (1.3 to 2.3)
Mortality [17]	PCI	48,851	1	aOR: 2.29 (1.79 to 2.92)
Mortality [18]	Cardiac surgery	13,843	1	12.5% versus 7.5%, P = 0.014
Mortality [19]	CABG	2,102	1	aOR: 0.99 (0.98 to 1.0)
Mortality [20]	ACS	7,922	1	aOR: 1.71 (1.34 to 2.17)
Meta-analyses on other outcomes
Heart failure^a[14]	ACS	152,849	5	OR: 1.96 (1.47 to 2.62)
Cardiogenic shock^a[14]	ACS	129,136	4	OR: 1.95 (1.04 to 2.64)
Reinfarction^b[9]	ACS	22,115	6	RR: 1.25 (1.02 to 1.53)

ACS: acute coronary syndrome; aHR: adjusted HR; aOR: adjusted odds ratio; CABG: coronary artery bypass graft; CI: confidence interval; HR: hazard ratio; OR: odds ratio; PCI: percutaneous coronary intervention; RR: relative risk.
This table reports data from two meta-analyses [9, 14] and six observational studies [15–20] that were not included in these meta-analyses.
^aOverall, the meta analysis conducted by Liu et al. [14] included 241,293 patients enrolled in 19 studies; the analysis on mortality (10 studies) disclosed a very important heterogeneity (I² = 84%).
^bOverall, the meta analysis conducted by Lawler et al. [9] included 233,144 patients. The analyses on mortality and reinfarction included 27 and 10 studies respectively; an important heterogeneity was found in both instances (I² = 98.2% and 48.4% respectively).