Within six hours of the MSCs infusion | Within 24 hours of the MSCs infusionb |
---|---|
1. An increase in vasopressor dose greater than or equal to a predefined threshold: | 1. Cardiac arrest |
 > 10 mcg/minute norepinephrine | 2. Death |
 > 100 mcg/minute phenylephrine |  |
 > 10 mcg/kg/minute dopamine |  |
 > 0.1 mcg/kg/minute of epinephrinea |  |
 Addition of a third vasopressor |  |
2. New ventricular tachycardia, ventricular fibrillation or asystole | Â |
3. New cardiac arrhythmia requiring cardioversion | Â |
4. Hypoxemia requiring an increase in the fraction of inspired oxygen of 0.2 or more and an increase in the level of PEEP of 5 cmH20 or more to maintain transcutaneous oxygen saturations in the target range of 88 to 95% | Â |
5. A clinical scenario consistent with transfusion incompatibility or transfusion-related infection (urticaria, wheezing) | Â |