From: The methodological quality of animal research in critical care: the public face of science
Criterion | Number of 77 publications meeting criterion,n(%) [95% confidence interval] |
---|---|
Animal descriptions reported | Â |
 Strain | 67 (87%) [78%, 93%] |
 Sex | 59 (77%) [66%, 85%] |
 Age | 29 (38%) [28%, 49%] |
 Developmental stage | 27 (35%) [25%, 46%] |
  Developmental stage when given | Neonate 5, juvenile 1, adult 21 |
 Weight | 60 (78%) [67%, 86%] |
 Animal sourcea | 33 (43%) [32%, 54%] |
 Baseline characteristics of treatment groups describedb | 23 (31%) [21%, 41%] |
Outcomes reported | Â |
 Number of animals in largest treatment group 10 or less | 61 (79%) [69%, 87%] |
 Extra animals used in the results (that were not stated in methods) | 31 (40%) [30%, 51%] |
  Number of extra animals unclear | 23 (74% of 31) [57%, 87%] |
  Number of extra animals >100 | 12 (39% of 31) [24%, 56%] |
 Numbers with denominators given when reporting the majority of outcomesc | 35 (45%) [35%, 57%] |
 No unaccounted animal numbers for the majority of outcomes | 24 (31%) [22%, 42%] |
 No animals excluded from analysis for the majority of outcomesd | 20 (26%) [17%, 37%] |
 Animal numbers provided in the majority of tables/graphs | 46 (60%) [49%, 70%] |
 Number of statistical comparisons reported |  |
  >40 | 49 (64%) [52%, 74%] |
  21 to 40 | 19 (25%) [16%, 35%] |
  5 to 20 | 9 (12%) [6%, 21%] |
 Any negative outcome reported in resultse | 15 (20%) [12%, 30%] |
 If applicable, toxicity or lack of toxicity to animals was mentioned | 11 (22% of 49) [13%, 36%] |
 No post hoc outcomes analyzedf | 40 (52%) [41%, 63%] |