Table 1 Characteristics of patients with initially proven and suspected invasive candidiasis
From: Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study
Patients’ characteristics | SAT for initially proven invasive candidiasis N = 291 | SAT for suspected invasive candidiasis N = 544 | P value |
|---|---|---|---|
At ICU admission | |||
Age (years) | 62.2 ± 15.4 | 61.9 ± 14.5 | 0.93 |
Male gender | 185 (63.6) | 337 (62.0) | 0.64 |
Reason for admission to ICU | |||
Medical | 119 (40.9) | 268 (49.3) | 0.02 |
Surgical | 161 (55.3) | 260 (47.8) | 0.04 |
Trauma | 16 (5.5) | 16 (2.9) | 0.08 |
C-reactive protein (mg/L) | 165.9 ± 109.4 | 173.1 ± 122.6 | 0.67 |
Creatinine (µmol/L) | 145.8 ± 109.6 | 132.1 ± 96.9 | 0.13 |
Red blood cell transfusion in ICU | 163 (56.0) | 289 (53.1) | 0.42 |
Platelet transfusion in ICU | 60 (20.6) | 119 (21.9) | 0.67 |
At SAT initiation | |||
Length of hospital stay before SAT (days) | 13 [6; 23] | 11 [4; 20] | <0.01 |
Length of ICU stay before SAT (days) | 5 [2; 14] | 4 [0; 11] | <0.01 |
Body temperature (°C) | 37.6 ± 1.3 | 37.7 ± 1.3 | 0.34 |
SAPS II | 46.2 ± 18.0 | 50.1 ± 18.7 | 0.006 |
SOFA score | 7.3 ± 4.8 | 8.3 ± 4.3 | 0.0007 |
Septic shock | 120 (41.2) | 330 (66.7) | <0.0001 |
Severe sepsis | 118 (40.6) | 203 (37.3) | 0.36 |
Risk factors for invasive candidiasisa | |||
Invasive mechanical ventilation | 196 (67.4) | 458 (84.2) | <0.0001 |
Central venous catheter | 278 (95.5) | 526 (96.7) | 0.44 |
Urinary catheterization | 280 (96.2) | 516 (94.9) | 0.50 |
Antibiotic treatment | 268 (92.1) | 481 (88.4) | 0.12 |
Total parenteral nutrition | 149 (51.2) | 235 (43.2) | 0.03 |
Hemodialysis or hemodiafiltration | 92 (31.6) | 160 (29.4) | 0.51 |
Corticosteroid treatment | 55 (18.9) | 151 (27.8) | 0.005 |
Surgery just before or during ICU stay | 197 (67.7) | 341 (62.7) | 0.15 |
Abdominal surgery | 156 (78.2) | 263 (79.2) | 0.80 |
Scheduled abdominal surgery | 16 (10.3) | 48 (18.3) | 0.03 |
Emergency abdominal surgery | 140 (89.7) | 215 (81.7) | 0.03 |
Mortality on D28 | 96 (34.4 %) | 163 (31.6 %) | 0.42 |