Treatment intensity and outcome of nonagenarians selected for admission in ICUs: a multicenter study of the Outcomerea Research Group

Garrouste-Orgeas, Maité; Ruckly, Stéphane; Grégoire, Charles; Dumesnil, Anne-Sylvie; Pommier, Cécile; Jamali, Samir; Golgran-Toledano, Dany; Schwebel, Carole; Clec’h, Christophe; Soufir, Lilia; Fartoukh, Muriel; Marcotte, Guillaume; Argaud, Laurent; Verdière, Bruno; Darmon, Michael; Azoulay, Elie; Timsit, Jean-François

doi:10.1186/s13613-016-0133-9

Annals of Intensive Care

Table 3 Comparison of characteristics of non-survivors between octogenarians (80–90) and nonagenarians (>90)

From: Treatment intensity and outcome of nonagenarians selected for admission in ICUs: a multicenter study of the Outcomerea Research Group

Variables	80–90 years old N = 36	>90 years old N = 44	p value
Age in years, median (IQR)	82.9 (81.1–85.2)	92 (91–93.5)	<0.01
Males, n (%)	18 (50)	18 (40.9)	0.42
Body mass index, kg/m², median (IQR)^a	24.2 (22.2–26)	22 (20–27.3)	0.24
Transfer from ward, n (%)	21 (58.3)	17 (38.6)	0.08
At least one underlying disease^b, n (%)	12 (33.3)	20 (45.5)	0.27
Hepatic	0	1 (2.3)	0.36
Cardiovascular	7 (19.4)	15 (34.1)	0.14
Pulmonary	4 (11.1)	7 (15.9)	0.54
Renal	2 (5.6)	2 (4.5)	0.84
Immunosuppression	1 (2.8)	2 (4.5)	0.68
Admission category, n (%)			1.00
Medicine	27 (75)	33 (75)
Unscheduled surgery	9 (25)	11 (25)
Scheduled surgery	0	0
Main symptom at admission, n (%)
Shock and multiorgan failure	16 (44.4)	16 (36.4)	0.46
Acute respiratory failure	13 (36.1)	16 (36.4)	0.98
Acute renal failure	0	1 (2.3)	0.36
Coma	4 (11.1)	3 (6.8)	0.50
Monitoring	3 (8.3)	2 (4.5)	0.68
Trauma	0	1 (2.3)	0.36
Severity of illness at admission, median (IQR)
SAPS II at admission	55.5 (45.5–76)	62 (49.5–81.5)	0.20
SAPS II leaving out age points	37.5 (27.5–58)	44 (31.5–63.5)	0.20
SOFA within 48 h of admission	7 (5–10.5)	8 (6–10)	0.41
Intensity of care within 48 h of admission, n (%)
Endotracheal mechanical ventilation	27 (75)	29 (65.9)	0.38
Noninvasive mechanical ventilation	9 (25)	6 (13.6)	0.20
Epinephrine/norepinephrine	23 (63.9)	23 (52.3)	0.30
Dobutamine	11 (30.6)	14 (31.8)	0.90
Central venous catheter	23 (63.9)	18 (40.9)	0.04
Arterial catheter	18 (50)	12 (27.3)	0.04
Renal replacement therapy	1 (2.8)	2 (4.5)	0.68
Urinary catheter	30 (83.3)	36 (81.8)	0.86
Pre-ICU hospital stay, days, median (IQR)	1.5 (0–6.5)	0 (0–1)	0.03
Length of ICU stay, days, median (IQR)	8.5 (2.5–19.5)	6 (2–16)	0.17
Length of hospital stay, median (IQR)	13 (5–24)	8 (3–18.5)	0.09
Decision to forgo life-sustaining treatments within 48 h of admission, n (%)
Advance withholding^c	11 (30.6)	8 (18.2)	0.20
Withholding	2 (5.6)	5 (11.4)	0.36
Withdrawing	2 (5.6)	2 (4.5)	0.84

IQR inter quartile range, SAPS II Simplified Acute Physiologic Score II, SOFA Sepsis Organ Failure Assessment, ICU intensive care unit
^a31 missing values
^bDefined by Knaus definition [17]
^cAnticipated decision of no escalation of life-sustaining intervention before this need arises

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