Table 2 Hemodynamic, pulmonary and clinical variables in animals with a drop in mean arterial pressure ≥10 %, within 24 h from bacterial inoculum
Group | p value | ||
|---|---|---|---|
Control (six animals) | Treatment (five animals) | ||
Hemodynamic variables | |||
Heart rate (beats/min) | 66.7 ± 18.6 | 75.0 ± 22.0 | 0.031 |
Central venous pressure (mm Hg) | 7.7 ± 3.8 | 7.9 ± 2.7 | 0.653 |
Mean arterial pressure (mm Hg) | 77.6 ± 8.3 | 77.9 ± 11.5 | 0.814 |
Mean pulmonary arterial pressure (mm Hg) | 20.8 ± 4.7 | 21.5 ± 4.7 | 0.388 |
Cardiac output (L/min) | 3.3 ± 1.1 | 3.6 ± 1.2 | 0.245 |
Systemic vascular resistance (dyne/s/cm5) | 1837.2 ± 593.5 | 1703.4 ± 567.9 | 0.252 |
Pulmonary vascular resistance (dyne/s/cm5) | 299.9 ± 127.6 | 274.5 ± 113.9 | 0.159 |
Vasopressor dependency index | 0.25 ± 0.10 | 0.30 ± 0.17 | 0.385 |
Mixed venous saturation (%) | 61.9 ± 11.4 | 60.3 ± 0.10 | 0.164 |
Pv-aCO2 | 8.52 ± 3.38 | 8.78 ± 3.15 | 0.678 |
Fluid balance (mL) | −48.9 ± 445.2 | −73.5 ± 501.9 | 0.842 |
Pulmonary variables | |||
PaO2/FiO2 | 353.8 ± 55.3 | 340.4 ± 81.8 | 0.792 |
PaCO2 | 40.3 ± 4.2 | 40.7 ± 4.5 | 0.598 |
Lung elastance (cm H2O/L) | 27.7 ± 9.2 | 25.3 ± 8.2 | 0.477 |
Pulmonary shunt (%) | 8.8 ± 4.2 | 9.2 ± 4.1 | 0.635 |
Clinical variables | |||
Temperature (°C) | 38.3 ± 1.2 | 39.0 ± 1.1 | <0.001 |
White blood cells (cells/µL) | 17.9 ± 6.8 | 13.7 ± 5.0 | 0.004 |
Neutrophils (%) | 45.6 ± 14.6 | 42.5 ± 12.9 | 0.364 |
Lymphocytes (%) | 46.1 ± 14.8 | 50.4 ± 13.3 | 0.234 |
Monocytes (%) | 2.5 ± 1.2 | 3.3 ± 2.8 | 0.631 |
Hb (g/dL) | 8.6 ± 1.2 | 8.2 ± 1.5 | 0.290 |
Platelet (cells/mm3) | 255.0 ± 61.8 | 258.2 ± 115.1 | 0.741 |
Creatinine (mg/dL) | 0.99 ± 0.2 | 1.3 ± 1.4 | 0.154 |