D0 | D1 | D2 | |||||||
---|---|---|---|---|---|---|---|---|---|
S+ | S− | p | S+ | S− | p | S+ | S− | p | |
S urea (mmol/l) | 10 [7.6–13] | 7.3 [6.2–12] | 0.56 | 16 [12–24] | 17 [14–21] | 0.26 | 22 [15–37] | 24 [20–27] | 0.54 |
S creat (µmol/l) | 105 [73–170] | 83 [64–117] | 0.36 | 177 [136–294] | 158 [115–197] | 0.15 | 227 [137–309] | 218 [155–314] | 0.65 |
24-h urinary output (l) | 2.3 [1.5–3.5] | 1.9 [1.0–2.5] | 0.05 | 2.4 [1.8–3.7] | 2.6 [1.7–3.3] | 0.46 | 2.7 [2.1–3.4] | 2.5 [1.7–3.3] | 0.32 |
Use of furo [n (%)] | 19 (73) | 24 (86) | 0.42 | 15 (59) | 25 (89) | 0.009 | 9 (35) | 21 (75) | 0.005 |
Dose of furo (mg/24 h) | 470 [215–1000] | 1000 [483–1000] | 0.06 | 500 [125–970] | 1000 [500–1000] | 0.01 | 500 [250–1000] | 1000 [500–1000] | 0.01 |
Diuretic RI (ml/mg) | 6 [2.9–15.4] | 2.1 [1.1–6.4] | 0.02 | 4.6 [3.6–26.4] | 3.2 [1.9–4.3] | 0.06 | 5.8 [2.5–8.2] | 3.4 [2.6–5.8] | 0.09 |
UrCl (ml/min) | 15 [8–20] | 6 [4–12] | 0.008 | 12.5 [8–20] | 7 [5–9] | 0.001 | 13 [9–18] | 6 [4–8] | <0.001 |
CrCl (ml/min) | 31 [15–41] | 18 [7–26] | 0.009 | 31 [18–40] | 15 [8–21] | 0.002 | 31 [16–42] | 13 [6–21] | <0.001 |
UUr (mmol/24 h) | 187 [72–339] | 85.9 [44–157] | 0.031 | 357 [195–569] | 147 [95–224] | 0.002 | 592 [230–672] | 236 [113–272] | 0.002 |
UCr (mmol/24 h) | 4.9 [2.5–6.4] | 2.55 [0.7–3.9] | 0.002 | 6.65 [5–8.8] | 3.5 [1.6–4.4] | <0.001 | 8.1 [6–9.5] | 4.4 [2.2–5.2] | <0.001 |
UrGR (µmol/min) | 530 [331–722] | 318 [254–442] | 0.02 | 428 [257–681] | 305 [232–393] | 0.08 | |||
CrGR (µmol/min) | 6.8 [5.8–9.9] | 4.1 [2.9–5.2] | <0.001 | 6.2 [4.8–7.8] | 4 [3.4–4.9] | 0.002 | |||
UUr/UrGR (%) | 51 [36–61] | 36 [24–48] | 0.03 | 71 [62–84] | 48 [31–60] | <0.001 | |||
UCr/CrGR (%) | 72 [53–85] | 57 [40–67] | 0.047 | 94 [77–100] | 67 [44–82] | <0.001 |