Outcomes | Pre-implementation period From 1 January 2013 to 31 December 2013 (n = 104 children) | Post-implementation period From 1 May 2014 to 31 March 2015 (n = 93 children) | ||||
---|---|---|---|---|---|---|
Overall trend before the implementation of protocola | p value | Immediate change after the implementation of protocolb | p value | Change in trend after the implementation of protocolc | p value | |
Duration of mechanical ventilation (days) | −0.35 (0.42) | 0.450 | 0.17 (1.64) | 0.923 | −0.05 (0.60) | 0.933 |
PICU length of stay (days) | −0.71 (0.90) | 0.476 | 6.56 (3.49) | 0.134 | −1.07 (1.28) | 0.450 |
Sufentanil | ||||||
Daily dose (μg/kg/day) | 0.19 (0.31) | 0.574 | 0.38 (1.22) | 0.770 | −0.21 (0.44) | 0.668 |
Duration of administration (h) | −3.31 (4.79) | 0.528 | −1.42 (18.6) | 0.943 | −1.32 (6.78) | 0.855 |
Midazolam | ||||||
Daily dose (mg/kg/day) | −0.12 (0.18) | 0.541 | 0.04 (0.69) | 0.955 | 0.02 (0.25) | 0.944 |
Duration of administration (h) | 0.27 (3.59) | 0.944 | −13.4 (13.9) | 0.389 | −3.39 (5.07) | 0.541 |
Ketamine | ||||||
Daily dose (mg/kg/day) | 1.11 (2.96) | 0.727 | 1.97 (11.5) | 0.872 | −3.06 (4.19) | 0.506 |
Duration of administration (h) | 7.06 (21.2) | 0.756 | −4.82 (82.1) | 0.956 | −17.2 (30.0) | 0.598 |