Table 7 Summaries of performance statistics of presepsin, procalcitonin, and C-reactive protein for diagnosing sepsis
Category | Biomarkers | Number of studies | Number of patients | Pooled sensitivity | Pooled specificity | AUC | Pooled DOR |
|---|---|---|---|---|---|---|---|
All | Presepsin | 13 | 2915 | 0.84 (0.79–0.88) | 0.75 (0.64–0.84) | 0.87 (0.84–0.90) | 16 (8–30) |
Procalcitonin | 13 | 2915 | 0.78 (0.72–0.83) | 0.79 (0.73–0.85) | 0.86 (0.82–0.88) | 14 (8–23) | |
All | Presepsin | 7 | 1204 | 0.83 (0.76–0.88) | 0.70 (0.55–0.81) | 0.85 (0.81–0.88) | 11 (7–18) |
C-reactive protein | 7 | 1204 | 0.77 (0.53–0.91) | 0.79 (0.62–0.89) | 0.85 (0.82–0.88) | 13 (5–36) | |
ED | Presepsin | 6 | 1822 | 0.83 (0.68–0.92) | 0.83 (0.67–0.92) | 0.90 (0.87–0.92) | 24 (5–113) |
Procalcitonin | 6 | 1822 | 0.79 (0.68–0.87) | 0.83 (0.72–0.91) | 0.88 (0.85–0.90) | 19 (7–52) | |
ICU | Presepsin | 5 | 452 | 0.88 (0.82–0.92) | 0.58 (0.42–0.73) | 0.87 (0.84–0.90) | 10 (5–18) |
Procalcitonin | 5 | 452 | 0.75 (0.68–0.81) | 0.75 (0.65–0.83) | 0.82 (0.78–0.85) | 9 (6–15) | |
Sepsis-1/2 | Presepsin | 7 | 2076 | 0.86 (0.76–0.91) | 0.79 (0.60–0.91) | 0.90 (0.87–0.92) | 23 (7–77) |
Procalcitonin | 7 | 2076 | 0.80 (0.72–0.87) | 0.83 (0.75–0.89) | 0.89 (0.86–0.91) | 20 (9–45) | |
Sepsis-1/2 | Presepsin | 3 | 694 | 0.86 (0.75–0.93) | 0.69 (0.33–0.90) | 0.87 (0.83–0.91) | 16 (6–38) |
C-reactive protein | 3 | 694 | 0.86 (0.44–0.98) | 0.85 (0.63–0.95) | 0.91 (0.86–0.93) | 34 (9–127) |