Table 1 Baseline characteristics of patients with postresuscitation shock (PRS) managed with hypothermia (33 °C) or normothermia (37 °C)

Age, years, median [IQR)

67.1 [56.9–74.9]

67.8 [59.5–77.1]

0.23

Males, n (%)

99 (62.2)

111 (61.7)

0.91

Charlson score, median [IQR)

4 (2–6)

4 (2–6)

0.37

Comorbidities, n (%)

 Cardiovascular

94/118 (79.7)

116/139 (83.5)

0.43

 Pulmonary

56/118 (47.4)

66/139 (47.5)

0.10

Cardiac arrest location, n (%)

0.001

 Home

74/159 (46.5)

95/180 (52.8)

 Public place

52/159 (32.7)

29/180 (16.1)

 Hospital

33/159 (20.8)

56/180 (31.1)

Arrest witnessed, n (%)

154/159 (96.9)

170/179 (95.0)

0.39

Basic life support provided by bystander, n (%)

120/153 (78.4)

133/171 (77.8)

0.89

First-recorded cardiac rhythm, n (%)

0.97

 Asystole

125/143 (87.4)

148/169 (87.6)

 Pulseless electrical activity

18/143 (12.6)

21/169 (12.4)

Cause of cardiac arrest, n (%)

*

 Cardiac

43/159 (27.0)

50/180 (27.8)

 Asphyxia

81/159 (51.0)

9/180 (50.5)

 Anaphylaxis

4/159 (2.5)

3/180 (1.7)

 Neurological

5/159 (3.1)

4/180 (2.2)

 Other medical cause

15/159 (9.4)

16/180 (8.9)

 Pulmonary embolism

8/159 (5.0)

9/180 (5.0)

 Trauma

1/159 (0.6)

2/180 (1.1)

 Drug poisoning

0/159 (0.0)

4/180 (2.2)

 Drowning

2/159 (1.3)

1/180 (0.6)

GCS score, median [IQR]

3 [3–3

3 [3–3]

0.62

Time to randomisation, min, median [IQR]

241.0 [192.0–285.0]

226.0 [178.5–276.5]

0.21

Temperature, °C, median [IQR]

35.5 [34.3–36.3]

35.4 [34.4–36.5]

0.86

No-flow time, min, median [IQR]

2 [0–5]

0 [0–5]

0.10

Low-flow time, min, median [IQR]

19 [10–28]

19.0 [10–28]

0.82

Serum lactate at admission, mmol/L, median [IQR]

6.1 [3.7–10.6]

7.3 [4.0–10.7]

0.40

Epinephrine injection, n (%)

150/159 (94.3)

174/180 (96.7)

0.30

Total epinephrine dose, mg, median [IQR]

3 (2, 5)

4 (2, 5)

0.44

PCI, n (%)

13/159 (8.2)

13/180 (7.2)

0.74

CAHP score, median [IQR]

190 [170–212]

195 [177–222]

0.073

Type of vasoactive drug at admission, n (%)

 Norepinephrine

90/159 (56.6)

93/180 (51.7)

0.36

 Epinephrine

83/159 (52.2)

100/180 (55.6)

0.54

 Dobutamine

7/159 (4.4)

11/180 (6.1)

0.48

 Dopamine

0/159 (0)

1/180 (0.6)

1.00

Early onset pneumonia, n (%)

35 (22.0)

40 (22.2)

0.96