Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial

Annals of Intensive Care

Table 3 Results (subgroup with PaO₂/FiO₂ < 200 mmHg)

Variable (unit)	Timepoint	Isoflurane			Propofol			p
		n	Mean (± SD)	SM/LSM change from BL	n	Mean (± SD)	SM/LSM change from BL	(isoflurane vs. propofol)
PaO₂/FiO₂ (mmHg)	BL	37	152 (± 33)		45	150 (± 38)
	EOT	36	186 (± 54)	0.43/30	45	214 (± 85)	0.84/66	0.029
	D7	20	198 (± 69)	0.43/36	20	174 (± 106)	0.42/33	0.933
FiO₂	BL	37	57 (± 14)		45	58 (± 17)
FiO₂	EOT	37	51 (± 13)	− 0.34/− 4.6	45	47 (± 11)	− 0.60/− 9.9	0.157
PaCO₂	BL	37	45 (± 10)		45	46 (± 13)
PaCO₂	EOT	36	47 (± 8)	0.28/3.1	45	45 (± 10	− 0.02/− 0.3	0.186
pH	BL	37	7.4 (± 0.1)		45	7.4 (± 0.1)
pH	EOT	36	7.4 (± 0.1)	0.01/− 0.00	43	7.4 (± 0.1)	0.18/0.02	0.424
V_T (ml/kg)	BL	37	6.6 (± 2.8)		45	6.0 (± 1.7)
V_T (ml/kg)	EOT	31	6.2 (± 2.4)	0.10/− 0.00	34	6.2 (± 2.3)	0.22/0.4	0.454
Ventilator mode	BL	37	Fully controlled: 51.4%; Partially assisted: 21.6% Fully assisted: 27%		45	Fully controlled: 68.9% Partially assisted: 24.4% Fully assisted: 6.7%
Ventilator mode	EOT	36	Fully controlled: 41.7% Partially assisted: 16.7% Fully assisted: 41.7%		45	Fully controlled: 48.9% Partially assisted: 24.4% Fully assisted: 26.7%

Change in PaO₂/FiO₂ ratio between baseline (BL) and end of study sedation (EOT, usually after 48 h)
LSM least squares mean, SD standard deviation, PaO₂ arterial partial pressure of oxygen, FiO₂ inspired fraction of oxygen, D7 day seven after randomization, SM standardized means mean divided by total pooled standard deviation, V_T tidal volume