Skip to main content

Table 4 In-hospital management and prognosis of cardiogenic shock patients according to the presence of mottling at admission

From: Mottling as a prognosis marker in cardiogenic shock

 

Overall (n = 660)

No mottling (n = 404)

Mottling (n = 256)

p

Medications used, n (%)

       

 Diuretics

532/657

81.0

332/402

82.6

200/255

78.4

0.186

 Volume expander

281/656

42.8

153/401

38.2

128/255

50.2

0.002

 Dobutamine

540/657

82.2

329/402

81.8

211/255

82.8

0.768

  If yes, maximum dose (mg/kg/min)

      

0.007

   5–10

340

62.6

225

68.0

115

54.2

 

   10–15

121

22.3

59

17.8

62

29.2

 

   > 15

44

8.1

26

7.9

18

8.5

 

   Unknown

38

7.0

21

6.3

17

8.0

 

 Norepinephrine

344/657

52.4

194/402

48.3

150/255

58.8

0.008

  If yes, maximum dose (mg/h)

      

0.128

   < 1

67

19.3

44

22.4

23

15.2

 

   1–5

177

51.0

99

50.5

78

51.7

 

   > 5

71

20.5

33

16.8

38

25.2

 

   Unknown

32

9.2

20

10.2

12

7.9

 

 Epinephrine

86/657

13.1

39/402

9.7

47/255

18.4

0.001

  If yes, maximum dose (mg/h)

      

0.395

   < 1

32

36.0

18

43.9

14

29.2

 

   1–5

34

38.2

12

29.3

22

45.8

 

   > 5

13

14.6

6

14.6

7

14.6

 

   Unknown

10

11.2

5

12.2

5

10.4

 

 Norepinephrine + dobutamine combination

299/657

45.5

165/402

41.0

134/255

52.6

0.004

 Levosimendan

47/657

7.2

34/402

8.5

13/255

5.1

0.576

 Dopamine

1/657

0.2

0/402

0.0

1/255

0.4

1.000

 Isoprenaline

30/657

4.6

15/402

3.7

15/255

5.9

0.198

 Antiarrhythmic

261/657

39.7

154/402

38.3

107/255

42.0

0.351

 Transfusion

115/656

17.5

60/401

15.0

55/255

21.6

0.030

 Fibrinolysis

11/656

1.7

5/401

1.3

6/255

2.4

0.353

Organ replacement therapies, n (%)

       

 Respiratory support

       

  Invasive

249/657

37.9

121/402

30.1

128/255

50.2

 < 0.001

  Non-invasive

183/657

27.9

103/402

25.6

80/255

31.4

0.109

 Mechanical circulatory support

122/658

18.5

66/402

16.4

56/256

21.9

0.079

  If yes

       

  IABP

43/121

35.5

23/66

34.9

20/55

36.4

0.862

  Impella

22/121

18.2

11/66

16.7

11/55

20.0

0.636

  ECLS

72/121

59.5

37/66

56.1

35/55

63.6

0.398

 Renal replacement therapy

101/659

15.3

50/403

12.4

51/256

19.9

0.009

Invasive cardiology, n (%)

       

 CAG

346

52.4

219

54.2

127

49.6

0.249

  If yes

       

  CAG result

      

0.205

  Normal

61

17.6

39

17.8

22

17.3

 

  1—Mono

71

20.5

51

23.3

20

15.7

 

  2—Bi

80

23.1

49

22.4

31

24.4

 

  3—Tri

76

22.0

50

22.8

26

20.5

 

  Unknown

58

16.8

30

13.7

28

22.0

 

  Culprit lesion

225/281

80.1

143/178

80.3

82/103

79.6

0.883

 Any PCI

192

29.1

121

30.0

71

27.7

0.541

 Right heart catheterisation

107/657

16.3

70/402

17.4

37/255

14.5

0.326

 Pace-maker implantation

28/625

4.5

16/388

4.1

12/237

5.1

0.582

 Defibrillator implantation

31/625

5.0

18/388

4.6

13/237

5.5

0.636

 Radiofrequency ablation

15/625

2.4

13/388

3.4

2/237

0.8

0.047

Discharge

       

 LVEF (%), mean ± SD

34.8

 ± 14.2

34.2

 ± 13.7

36

 ± 14.9

0.221

 n

375

 

240

 

135

 

 LVEF variation*, mean ± SD

8.2

 ± 14.0

7.4

 ± 13.7

9.5

 ± 14.5

0.172

 n

372

 

238

 

134

 

 Length of stay in ICU/ICCU (days), median (IQR)

12 (7–21)

 

11 (7–20)

 

13 (8–25)

0.061

 n

380

 

232

 

148

 

 Length of stay in hospital (days), median (IQR)

16 (11–27)

 

16 (11–25)

 

19 (12–31)

0.033

 n

367

 

238

 

129

 

 Discharge mode

      

0.074

  Home

141

25.4

96

28.3

45

20.8

 

  Rehabilitation

38

6.8

23

6.8

15

6.9

 

  Transferred (other center/other department)

183

33.0

116

34.2

67

31.0

 

  Death

190

34.2

103

30.4

87

40.3

 

  Other

3

0.5

1

0.3

2

0.9

 

 Registration on transplant waiting list

33/552

6.0

21/333

6.3

12/219

5.5

0.689

Mortality

       

 30-day mortality

173

26.2

94

23.3

79

30.9

0.031

 1-year mortality**

308

46.7

170

42.1

138

53.9

0.003

  1. Values in italics indicate the number of patients included in the statistical analysis
  2. CAG, coronary arteriography; ECLS, extracorporeal membrane oxygenation; IABP, intra-aortic balloon pump; ICCU, intensive cardiac care unit; ICU, intensive care unit; IQR, interquartile range; LVEF, left ventricular ejection fraction; PCI, percutaneous coronary intervention; SD, standard deviation
  3. *At discharge compared with admission
  4. **2.5% of patients lost to follow-up at 1-year