Table 1 Clinical characteristics of patients
NLF | ACLF | Combined | |
|---|---|---|---|
Number of patients | 9 | 9 | 18 |
Males | 5 (56%) | 7 (78%) | |
Number of PK samples | 259 | 195 | 454 |
Number of PK samples per patient | 30 (12–33) | 21 (12–31) | 25 (12–33) |
Age (Years) | 69 (8) | 52 (13) | 61 (14) |
Weight (kg) | 88 (15) | 87 (11) | 87 (13) |
Height (cm) | 172 (7) | 177 (8) | |
BMI (kg/m2) | 29.7 (4.8) | 27.8 (4.5) | |
APACHE II | 28 (10) | 30 (10) | 29 (10) |
SAPS II | 52 (15) | 56 (14) | 54 (14) |
MELD | n/a | 31 (7) | n/a |
CLIF-SOFA | n/a | 15 (4) | |
PT (%) | 83 (21) | 60 (28) | 72 (27) |
Bilirubin (mg/dL) | 2.0 (3.0) | 10.8 (10.7) | 6.4 (8.9) |
Antithrombin (%) | 85 (25) | 34 (22) | 59 (35) |
RRT modes and flow rates | |||
CVVHD (n) | 8 | 5 | |
Blood flow (ml/min) | 100 (80–120) | 120 (100–350) | |
Dialysate flow (ml/h) | 2000 (1500–3300) | 2400 (2000–4800) | |
Ultrafiltration (ml/h) | 150 (0–250) | 150 (0–200) | |
CVVH (n) | 1 | 4 | |
Blood flow (ml/min) | 200 | 200 (150–200) | |
Replacement fluid (ml/h) | 2000 | 2000 (2000–4000) | |
Ultrafiltration (ml/h) | 150 | 0 (0–80) | |