Table 2 Parameter estimates of the final model of linezolid
Model parameter | Typical value | Variability | ||
|---|---|---|---|---|
Value | 95% CI | % CV | 95% CI | |
Body clearance (L/h) | 6.17 | 4.97; 7.55 | 11.6 (BSV) 60.3 (BOV) | 1.43; 28.6 45.9; 80.5 |
Central volume of distribution (L) | 27.5 | 22.3; 33.3 | 43.0 (BSV) 6.60 (BOV) | 30.33; 62.5 0.89; 18.7 |
RRT clearance (L/h) | 1.65 | 1.39; 1.94 | 33.8 (BSV) | 23.4; 46.6 |
Inter-compartmental clearance (L/h) | 9.58 | 7.97; 11.2 | ||
Peripheral volume of distribution (L) | 43.7 | 22.3; 77.1 | 104.9 (BSV) 112.7 (BOV) | 87.2; 142 |
Change in body clearance for patients with liver disease (%) | − 78.7 | − 87.0; − 67.1 | ||
Pre-filter proportional error (%) | 12.0 | 10.4; 14.1 | ||
Post-filter proportional error (%) | 14.9 | 12.7; 16.7 | ||
Dialysate proportional error (%) | 22.9 | 19.8; 26.8 |