Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study

Annals of Intensive Care

Table 2 Logistic regression models, odds ratio for mortality estimated for organ failure (SOFA ≥ 3 in each organ system)

SOFA component	Number of patients with organ failure	ICU mortality		30-day mortality
SOFA component	Number of patients with organ failure	Crude	OR (95% CI)	Crude	OR (95% CI)
Respiratory SOFA	1155 (30.3%)	38.1% vs. 21.5%, p < 0.001	1.53 (1.29 to 1.81)	49.3% vs. 34.0%, p < 0.001	1.36 (1.16 to 1.60)
Cardiovascular SOFA	1583 (41.5%)	37.1% vs. 19.1%, p < 0.001	1.69 (1.43 to 2.01)	49.0% vs. 31.3%, p < 0.001	1.54 (1.32 to 1.80)
Hepatic SOFA	57 (1.5%)	45.6% vs. 26.3%, p = 0.002	1.74 (0.97 to 3.15)	59.6% vs. 38.3%, p = 0.002	1.88 (1.05 to 3.40)
Renal SOFA	444 (11.6%)	38.3% vs. 25.0%, p < 0.001	1.87 (1.48 to 2.35)	50.7% vs. 37.1%, p < 0.001	1.71 (1.37 to 2.13)
Neurological SOFA	940 (24.7%)	47.4% vs. 19.7%, p < 0.001	2.79 (2.34 to 3.33)	58.2% vs. 32.3%, p < 0.001	2.21 (1.87 to 2.62)
Coagulation SOFA	76 (2.0%)	50.0% vs. 26.1%, p < 0.001	2.72 (1.66 to 4.48)	63.2% vs. 38.2%, p < 0.001	2.69 (1.63 to 4.44)

Aside from the SOFA score components the regression model included age, sex, reason for ICU admission and CFS score. Age and CFS score were treated as continuous variables in the model