Table 1 Baseline characteristicsa
From: Clinical Warburg effect in lymphoma patients admitted to intensive care unit
|  | No Warburg/normal lactate level (n = 69) | No Warburg/high lactate level (n = 20) | Clinical Warburg effect (n = 46) |
|---|---|---|---|
Demographic characteristics | |||
 Sex male—no. (%) | 49 (71) | 13 (65) | 26 (58) |
 Age—year | 58 (40–64) | 61 (52–64) | 60 (50–72) |
Hemopathy characteristics | |||
 Lymphoma type —no. (%) | |||
  DLBCLb | 22 (32) | 10 (50) | 19 (41) |
  Burkitt | 8 (12) | 1 (5) | 11 (24) |
  Hodgkin | 8 (12) | 1 (5) | 1 (2) |
  T cell lymphoma | 8 (12) | 3 (15) | 12 (26) |
  Other | 23 (33) | 5 (25) | 3 (7) |
 Inaugural malignancy—no. (%) | 60 (87) | 14 (70) | 32 (70) |
 Stade IVc—no. (%) | 63 (96) | 20 (100) | 45 (98) |
 EBV associatedd—no. (%) | 11 (18) | 4 (20) | 4 (9) |
 HIV positive—no. (%) | 13 (19) | 4 (20) | 7 (15) |
 Serum LDH—UI/L | 828 (433–1591) | 890 (537–2066) | 2422 (1099–4763) |
 Ki67—% | 88 (80–95) | 85 (80–90) | 90 (90–100) |
 Associated hemophagocytic lymphohistiocytosis—no. (%) | 18 (26) | 6 (30) | 5 (11) |
 Associated tumor lysis syndrome—no. (%) | 22 (32) | 8 (40) | 25 (54) |
 Spontaneous tumor lysis syndrome—no. (%) | 16 (23) | 6 (30) | 18 (39) |
Clinical presentation at admission | |||
 SAPS II | 34 (23–51) | 49 (40–59) | 36.5 (28–49) |
 Total SOFA score at admission | 3 (0–6) | 6 (4–9) | 2 (0–4) |
 Body temperature—°C | 37.2 (36.7–37.8) | 37.0 (36.2–37.4) | 37.5 (36.8–38.0) |
 Mean blood pressure—mmHg | 87 (78–100) | 80 (72–89) | 98 (87–106) |
 Heart rate—bpm | 101 (88–110) | 108 (103–121) | 104 (91–120) |
 Respiratory rate—/min | 22 (17–26) | 24 (20–29) | 23 (20–28) |
 Mottling skin—no. (%) | 1 (1) | 6 (30) | 0 (0) |
 Metformin—no. (%) | 4 (6) | 5 (25) | 0 (0) |
Biological parameters at admission | |||
 Serum lactate—mmol/L | 1.5 (1.1–1.7) | 5.1 (2.6–8.6) | 4.4 (3.6–7.6) |
 Serum pH | 7.42 (7.38–7.44) | 7.38 (7.28–7.43) | 7.40 (7.36–7.43) |
 PaCO2—mmHg | 38 (34–43) | 31 (26–39) | 33 (29–38) |
 Serum bicarbonate—mmol/L | 24 (22–29) | 22 (17–24) | 20 (18–23) |
 Glycemia—mmol/L | 6.5 (5.9–7.3) | 7.0 (6.0–8.4) | 5.3 (3.7–6.2) |
 Hypoglycemia—no. (%) | 6 (9) | 3 (15) | 26 (57) |
 PT—% | 77 (64–92) | 70 (55–83) | 76 (66–85) |
 Factor V—% | 124 (86–148) | 100 (79–125) | 130 (106–162) |
 Acute liver failure—no. (%) | 2 (3) | 3 (15) | 0 (0) |
 Serum uric acid—mmol/L | 387 (271–595) | 357 (276–572) | 551 (360–716) |
 Hypercalcemia—no. (%) | 8 (12) | 3 (15) | 11 (24) |
 Serum albumin—g/L | 31 (26–36) | 31 (26–36) | 33 (26–35) |
Organ support at ICU admission | |||
 Vasopressor—no. (%) | 16 (23) | 13 (65) | 0 (0) |
 Mechanical ventilation—no. (%) | 16 (23) | 9 (45) | 4 (9) |
 Renal replacement therapy—no. (%) | 14 (20) | 9 (45) | 8 (17) |