Table 1 Baseline characteristics and outcomes in full population
From: Prediction of pulmonary aspergillosis in patients with ventilator-associated pneumonia
Variables | Non aspergillus related VAP | ICU-acquired pulmonary aspergillosis | p-value |
|---|---|---|---|
n = 176 | n = 39 | ||
Age, year | 64 [53–70] | 70 [63–73] | 0.003 |
Male—no. (%) | 136 (77.3) | 33 (84.6) | 0.426 |
Year of admission | 0.687 | ||
2020—no. (%) | 65 (36.9) | 12 (30.8) | |
2021—no. (%) | 79 (44.9) | 18 (46.2) | |
2022—no. (%) | 32 (18.2) | 9 (23.1) | |
Immunocompromised—no. (%) | 44 (25.0) | 24 (61.5) | < 0.001 |
Oncohematological disorder—no. (%) | 26 (14.8) | 12 (30.8) | 0.034 |
Immunomodulatory treatment—no. (%)a | 9 (5.6) | 14 (41.2) | < 0.001 |
Solid organ transplant—no. (%) | 3 (1.7) | 3 (7.7) | 0.075 |
Neutropenia < 0.5 G/L | 5 (2.8) | 7 (17.9) | 0.001 |
Steroids | 77 (43.8) | 29 (74.4) | 0.001 |
< 1 mg/kg of prednisolone equivalent | 69 (41.3) | 17 (63.0) | 0.059 |
≥ 1 mg/kg of prednisolone equivalent | 9 (5.1) | 13 (33.3) | < 0.001 |
Simplified Acute Physiology Score II | 50 [37–68] | 47 [36–52] | 0.149 |
Reason for admission | |||
Medical (vs surgical)—no. (%) | 161 (91.5) | 39 (100.0) | 0.123 |
Trauma—no. (%) | 12 (6.8) | 0 (0.0) | 0.130 |
COVID-19—no. (%) | 97 (55.1) | 25 (64.1) | 0.397 |
Influenza—no. (%) | 1 (0.7) | 2 (6.9) | 0.077 |
Period of admission | 0.660 | ||
Winter—no. (%) | 54 (30.7) | 12 (30.8) | |
Spring—no. (%) | 52 (29.5) | 8 (20.5) | |
Summer—no. (%) | 24 (13.6) | 7 (17.9) | |
Fall—no. (%) | 46 (26.1) | 12 (30.8) | |
Localization before admission | 0.078 | ||
Other ICU—no. (%) | 29 (16.5) | 1 (2.6) | |
Home—no. (%) | 82 (46.6) | 21 (53.8) | |
Long care facility—no. (%) | 4 (2.3) | 0 (0.0) | |
Acute care ward—no. (%) | 61 (34.7) | 17 (43.6) | |
Early management | |||
Systemic antibiotic at admission—no. (%) | 115 (65.3) | 30 (76.9) | 0.227 |
Vascular catheter—no. (%) | 169 (96.0) | 39 (100.0) | 0.443 |
Multiple site decontamination—no. (%) | 45 (25.6) | 14 (35.9) | 0.234 |
Biological parameters at admission | |||
Creatininemia, µmol/L | 85 [64–135] | 84.50 [62–139.50] | 0.660 |
White blood cell count, Giga/L | 10.95 [8.83–16.43] | 8.67 [6.20–11.78] | 0.004 |
Neutrophilic count at admission, Giga/L | 9.20 [6.37–14.56] | 7.15 [3.55–10.36] | 0.002 |
Lymphocyte, Giga/L | 0.79 [0.55–1.28] | 0.54 [0.24–0.74] | < 0.001 |
PaO2/FiO2, mmHg | 137 [102–209] | 111 [86–129] | 0.002 |
Outcomes | |||
In ICU death—no. (%) | 52 (29.5) | 21 (53.8) | 0.007 |
Length of stay, days | 26 [17–39.50] | 27 [16.50–38.50] | 0.907 |
Length of mechanical ventilation, days | 22 [13–36] | 21 [11.50–34.50] | 0.319 |