Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study

Annals of Intensive Care

Table 3 Effects on high-flow nasal cannula versus standard oxygen on hemodynamics and cardiac biomarkers

Variable	Standard oxygen	HFNC	p value
Systolic arterial pressure, mmHg	143 ± 19	140 ± 19	0.238
Diastolic arterial pressure, mmHg	73 ± 15	71 ± 14	0.427
Mean arterial pressure, mmHg	98 ± 14	96 ± 13	0.310
Heart rate, bpm	85 ± 12	86 ± 12	0.238
CVP, mmHg	3 [1–7]	4 [1–6]	0.792
SvcO₂, %	75 ± 10	75 ± 7	0.750
Pv-aCO₂ gap	2.5 ± 1.9	3.4 ± 2.2	0.273
NT-proBNP, pg/ml	355 [152–901]	329 [147–962]	0.314
Troponin T, pg/ml	17.2 [10.5–29.9]	19.1 [10.3–32.0]	0.206

Abbreviations: HFNC: high-flow nasal cannula; SvcO₂: central venous oxygen saturation; CVP: central venous pressure; Pv-aCO₂ gap: venous-to-arterial carbon dioxide gap; NT-proBNP: N-terminal pro-B-type natriuretic peptide. Normally distributed variables are expressed as mean ± standard deviation; non-normal distributed variables are expressed as median and [interquartile range]. p values were calculated using a two-way repeated measures ANOVA