Fig. 4

Cumulative incidence of mortality up to 28 day. A Patients were stratified into two groups based on the highest quartile (Q4) versus the other quartiles (Q1 + Q3) for Nu H3.1. B Patients were stratified into 4 groups based on quartiles: Q4 (labeled +) vs Q1 + Q3 (labeled-) for Nu H3.1 and interleukin-6. First group: Nu H3.1–/ IL-6 – (n = 80 patients), second group: Nu H3.1–/IL-6 + (n = 20) third group Nu H3.1–/IL-6 + (n = 20), fourth group Nu H3.1 + / IL-6 + (n = 18). Cumulative incidence curves were estimated with Kaplan–Meier method on D 1–2. The p value was calculated by log rank test. Cumulative incidence curves for day 3–4 and 6–8 Nu H3.1 concentration are shown in Additional file 1: Figure S1