Table 1 Characteristics of enrolled patients

Age (years)

60 [49–70]

63 [52–73]

59 [49–70]

Sex (female)

71 (35%)

15 (30%)

56 (37%)

BMI (kg/m²)

26.1 [23.5–30.7]

25.6 [23.5–27.8]

26.1 [23.4–31.2]

SOFA score

4 [3–6]

5 [3–6]

4 [3–6]

Charlson comorbidity Index

2 [1–4]

2 [1–3]

2 [1–4]

ICU admission reason

 Medical

178 (88%)

45 (90%)

133 (87%)

  ARDS COVID

56 (28%)

19 (38%)

37 (25%)

  Septic shock

41 (20%)

9 (18%)

32 (21%)

  ARDS

17 (8%)

6 (12%)

11 (7%)

  Cardiac arrest

17 (8%)

3 (6%)

14 (9%)

  Acute liver failure

7 (4%)

2 (4%)

5 (3%)

  Others^a

40 (20%)

6 (12%)

34 (22%)

 Surgical

25 (12%)

5 (10%)

20 (13%)

  Trauma

6 (3%)

2 (4%)

4 (3%)

  Others^b

19 (9%)

3 (6%)

16 (10%)

 Laboratory data at enrollment

  Hct (%)

33 [28–38]

32 [29–38]

33 [27–38]

  Platelets (10³/mm³)

202 [129–269]

199 [141–254]

207 [121–270]

  INR

1.19 [1.08–1.46]

1.2 [1.07–1.48]

1.19 [1.12–1.36]

  aPTT Ratio

0.95 [0.85–1.09]

0.95 [0.86–1.09]

0.94 [0.84–1.1]

  Fibrinogen (mg/dL)

436 [264–643]

421 [245–642]

523 [313–657]

  D-dimers (mg/dL)

3585 [1436–10476]

3585 [1357–12300]

3586 [1677–6484]

 Anticoagulation during ICU stay

185 (91%)

48 (96%)

137 (90%)

  Prophylaxis

105 (52%)

26 (52%)

79 (52%)

  Therapy

80 (39%)

22 (44%)

58 (38%)

 Antiplatelet therapy during ICU stay

43 (21%)

8 (16%)

35 (23%)

  Monotherapy

32 (16%)

7 (14%)

25 (16%)

  Double

11 (5%)

1 (2%)

10 (7%)

ECMO

21 (10%)

4 (8%)

17 (11%)

Surgical intervention^c

53 (26%)

12 (24%)

41 (27%)

N. Catheters during ICU stay

2 [1, 2]

2 [1, 2]

2 [2–2]

  1

85 (42%)

9 (18%)

76 (50%)

  2

80 (39%)

29 (58%)

51 (33%)

  3

27 (13%)

9 (18%)

18 (12%)

  4

7 (3%)

2 (4%)

5 (3%)

  5

3 (2%)

0 (0%)

3 (2%)

  6

1 (1%)

1 (2%)

0 (0%)