Skip to main content
Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: High-flow nasal cannula oxygen versus conventional oxygen therapy for acute respiratory failure due to COVID-19: a systematic review and meta-analysis

Fig. 3

Trial sequential analysis of intubation outcome. Studies are shown as black-filled squares on the cumulative Z curve. For the conventional boundaries, p = 0.05 and z =|1.96|. The TSA software only generates Z scores from − 8 to + 8. The cumulative Z curve crosses the conventional boundary for benefit and the trial sequential monitoring boundary for benefit without reaching the required information size line at n = 2776 showing that, compared with COT, HFNC has clinical benefit, leading to reduced risk of intubation. COT conventional oxygen therapy; HFNC high-flow nasal cannula; TSA trial sequential analysis

Back to article page