Use of airway pressure-based indices to detect high and low inspiratory effort during pressure support ventilation: a diagnostic accuracy study

Annals of Intensive Care

Table 2 Diagnostic performance for detecting high inspiratory effort

Indices	AUC	Cutoff	Sensitivity	Specificity	PPV	NPV
Classified by PTP_mus per minute (> 200 cmH₂O s min⁻¹)
P_0.1 (cmH₂O)	0.94 (0.91–0.98)	2.2	1.00 (0.80–1.00)	0.86 (0.81–0.90)	0.35 (0.28–0.42)	1.00 (0.98–1.00)
∆P_occ (cmH₂O)	0.93 (0.88–0.97)	8.4	1.00 (0.80–1.00)	0.75 (0.69–0.81)	0.23 (0.19–0.27)	1.00 (0.98–1.00)
PMI (cmH₂O)	0.93 (0.88–0.98)	2.1	0.88 (0.64–0.99)	0.81 (0.76–0.86)	0.26 (0.20–0.32)	0.99 (0.96–1.00)
Classified by P_mus (> 10 cmH₂O)
P_0.1 (cmH₂O)	0.95 (0.92–0.98)	2.0	0.91 (0.77–0.98)	0.89 (0.84–0.93)	0.57 (0.47–0.66)	0.98 (0.95–0.99)
∆P_occ (cmH₂O)	0.93 (0.89–0.98)	9.2	0.94 (0.81–0.99)	0.84 (0.79–0.89)	0.50 (0.42–0.58)	0.99 (0.96–1.00)
PMI (cmH₂O)	0.93 (0.89–0.98)	2.8	0.80 (0.63–0.92)	0.92 (0.88–0.96)	0.64 (0.52–0.74)	0.97 (0.93–0.98)

95% confidence intervals are shown in parentheses for diagnostic performance measures
PTP_mus: inspiratory muscle pressure–time product; P_0.1: negative swing of airway pressure against end-expiratory airway occlusion at first 100 ms; ∆P_occ: the maximal negative swing of airway pressure against end-expiratory airway occlusion; PMI: pressure muscle index; P_mus: inspiratory muscle pressure; AUC: area under the receiver-operating-characteristics curve; PPV: positive predictive value; NPV: negative predictive value