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Annals of Intensive Care

Table 1 Patient characteristics of patients who developed acute kidney injury (KDIGO classes 1–3 defined by changes in creatinine) during the first five days after cardiac arrest

From: The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials

 

Data available

All patients

Any AKI

n = 86

No AKI

n = 141

p value

Sex, n (%) (male)

227

176 (78)

64 (74)

112 (79)

0.38

Age, years (IQR)

227

63 (54–72)

67 (58–77)

61 (52–68)

 < 0.01

BMI (IQR)

209

23 (21–25)

23 (22–26)

23 (21–25)

0.10

Cardiac arrest characteristics and resuscitation factors

 Bystander CPR or compressions only, n (%)

221

159 (72)

46 (55)

113 (83)

 < 0.01

 Public place, n (%)

223

111 (50)

38 (44)

73 (53)

0.19

 Initial rhythm

226

    

 VF, n (%)

 

183 (81)

58 (67)

125 (89)

 < 0.01

 VT, n (%)

 

7 (3)

3 (4)

4 (3)

 PEA, n (%)

 

7 (3)

5 (6)

2 (1)

 ASY, n (%)

 

29 (13)

20 (23)

9 (6)

 Time to ROSC, minutes (IQR)

222

20 (14–25)

20 (15–30)

18 (14–25)

0.10

Medical history

 HTA, n (%)

221

106 (48)

51 (61)

55 (40)

 < 0.01

 Diabetes, n (%)*

104

10 (10)

9 (15)

1 (2)

0.03

 COPD/asthma, n (%)

226

20 (9)

12 (14)

8 (6)

0.48

Norepinephrine at admission, mean (IQR)

209

0.13 (0.10–0.24)

0.15 (0.10–0.25)

0.13 (0.09–0.23)

0.86

Treatment

 CAG, n (%)

223

187 (84)

69 (81)

118 (86)

0.40

 PCI, n (%)

224

112 (50)

42 (49)

70 (50)

0.89

MAP treatment group

227

   

0.51

 High-normal, n (%)

 

112 (49)

40 (36)

72 (64)

 

 Low-normal, n (%)

 

115 (51)

46 (40)

69 (60)

Duration of mechanical ventilation, days (IQR)

195

4 (2–7)

5 (3–8)

4 (2–6)

0.01

RRT, n (%)

226

3 (1.7)

3 (3.5)

0 (0)

0.03

Length of stay in ICU, days (IQR)

221

6 (4–9)

6 (4–12)

5 (3–8)

0.10

Death in ICU, n (%)

227

91 (40%)

52 (61%)

39 (28%)

 < 0.01

Death in hospital, n (%)*

     

(Neuroprotect trial)

106

106 (47%)

42 (68%)

20 (32%)

 < 0.01

Mortality 30d, n (%)

227

93 (41%)

53 (62%)

33 (23%)

 < 0.01

CPC 6 months, poor, n (%)

227

106 (47)

59 (69)

47 (33)

 < 0.01

  1. A two-sided p value < 0.05 was considered statistically significant (in bold)
  2. The numbers are median (interquartile range), mean (95% CI), or n (%). BMI body mass index (kg/m2), CPR cardiopulmonary resuscitation, VF ventricular fibrillation, VT ventricular tachycardia, PEA pulseless electrical activity, ASY asystole, ROSC return of spontaneous circulation, HTA arterial hypertension, COPD chronic obstructive pulmonary disease, ACE angiotensin-converting enzyme, CAG coronary angiography, PCI percutaneous coronary intervention, SOFA sequential organ failure assessment, MAP mean arterial pressure, ICU intensive care unit, CPC cerebral performance category, RRT Renal replacement therapy
  3. *”Diabetes mellitus and Death in hospital” data were available only in Neuroprotect trial
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