The effect of higher or lower mean arterial pressure on kidney function after cardiac arrest: a post hoc analysis of the COMACARE and NEUROPROTECT trials

Annals of Intensive Care

Table 2 Cox proportional hazards regression analysis for time to acute kidney injury (AKI) defined as any KDIGO class 1–3 during the first five days in the ICU and multivariate competing risk analysis when outcome is AKI 1–3 and death

	Univariate HR (95% CI)	P value	Multivariate HR (95% CI)	P value	Multivariate CR HR (95% CI) Outcome: AKI 1–3	P value	Multivariate CR HR (95% CI) Outcome: death	P value
Age	1.03 (1.01–1.05)	0.02	1.02 (1.00–1.04)	0.06	1.02 (1.00–1.05)	0.06	1.02 (1.00–1.04)	0.11
Lack of bystander CPR	2.59 (1.68–3.98)	< 0.01	2.19 (1.38–3.48)	< 0.01	2.42 (1.49–3.95)	< 0.01	2.19 (1.38–3.48)	0.85
Initial rhythm, non-shockable	2.91 (1.82–4.64)	< 0.01	2.78 (1.65–4.68)	< 0.01	2.76 (1.60–4.78)	< 0.01	2.78 (1.65–4.68)	0.02
HTA	1.96 (1.26–3.05)	0.03	1.72 (1.07–2.78)	0.03	1.71 (1.03–2.83)	0.04	1.72 (1.07–2.78)	0.14
Time to ROSC	1.03 (1.00–1.05)	0.02	1.04 (1.02–1.06)	< 0.01	1.04 (1.02–1.07)	< 0.01	1.04 (1.02–1.06)	0.42
MAP high	0.87 (0.57–1.33)	0.51	0.78 (0.50–1.23)	0.29	0.79 (0.49–1.28)	0.34	0.78 (0.50–1.23)	0.60

A two-sided p value < 0.05 was considered statistically significant (in bold)
HR hazard ratio, CI Confidence interval, CR competing risk, MAP mean arterial pressure