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Annals of Intensive Care

Table 2 Univariate and multivariate analysis of factors associated with acute kidney injury meeting the criteria for the stage 3 of the KDIGO classification

From: Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock

 

Univariate analysis

Multivariate analysis

OR

IC 95%

p

OR

IC 95%

p

DIC

3.12

1.99–4.91

 < 0.001

2.74

1.53–4.91

 < 0.001

Age (per 1-year increment)

1.0

0.99–1.02

0.645

0.97

0.95–0.99

0.011

Male sex

0.96

0.62–1.50

0.865

–

–

–

SAPS II (per 1pt increment)

1.06

1.05–1.08

 < 0.001

1.06

1.04–1.07

 < 0.001

SOFA (per 1pt increment)

1.44

1.31–1.57

 < 0.001

–

–

–

Chronic hypertension

1.80

1.16–2.81

0.009

1.75

0.95–3.20

0.071

Diabetes

1.56

0.98–2.48

0.059

1.41

0.77–2.60

0.265

Chronic heart failure

1.35

0.58–3.16

0.483

–

–

–

CKD

1.78

0.97–3.26

0.063

2.42

1.03–5.68

0.043

Liver cirrhosis

2.71

0.89–8.27

0.079

1.00

0.26–3.91

0.996

Cancer

0.68

0.38–1.22

0.194

0.52

0.25–1.11

0.091

COPD

0.82

0.47–1.42

0.475

–

–

–

Source of infection

 Lung

1.15

0.74–1.80

0.532

–

–

–

 Abdominal

1.77

0.99–3.19

0.056

1.66

0.80–3.43

0.175

 Urinary tract

0.90

0.53–1.53

0.703

–

–

–

 Bloodstream infection

0.79

0.48–1.29

0.349

–

–

–

 Nosocomial infection

0.78

0.36–1.68

0.525

–

–

–

 Immunosuppression

1.13

0.58–2.22

0.713

–

–

–

 Cocci gram positive

0.78

0.49–1.22

0.269

–

–

-

 Bacillus gram negative

1.49

0.97–2.28

0.071

1.47

0.86–2. 45

0.161

Organ-support at inclusion

 Epinephrine

6.06

2.67–13.73

 < 0.001

1.99

0.71–5.55

0.187

 Dobutamine

1.71

1.00–2.92

0.052

1.28

0.63–2.59

0.494

 Norepinephrine > 1 µg/kg/min at day 1

3.18

1.99–5.07

 < 0.001

1.31

0.72–2.39

0.372

 Fluid before inclusion > 1L

5.57

1.21–17.18

0.025

4.34

0.82–23.1

0.085

 Invasive mechanical ventilation

5.13

2.11–12.50

 < 0.001

2.50

0.86–7.27

0.092

 Nephrotoxic drugs, yes

0.52

0.19–1.43

0.207

0.77

0.18–3.23

0.724

 Nephrotoxic drugs

1.06

0.89–1.25

0.514

–

–

–

  1. Bolditalic characters were proposed to illustrate values who reached statistical significancy, i.e. p < 0.05
  2. CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; DIC, disseminated intravascular coagulation; OR, odds ratio; SAPS II, Simplified Acute Physiologic Score II; SOFA, Sequential Organ Failure Assessment
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