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Annals of Intensive Care

Table 3 Univariate and multivariate analysis of factors associated with renal replacement therapy requirement during the ICU stay

From: Disseminated intravascular coagulation is strongly associated with severe acute kidney injury in patients with septic shock

 

Univariate analysis

Multivariate analysis

OR

IC 95%

p

OR

IC 95%

p

DIC

3.32

2.07–5.33

 < 0.001

2.82

1.53–5.20

0.001

Male sex

0.89

0.55–1.42

0.62

–

–

–

Age, (per 1-year increment)

1.01

0.99–1.02

0.364

0.97

0.95–1

0.048

SAPS II (per 1pt increment)

1.06

1.04–1.08

 < 0.001

1.06

1.04–1.07

 < 0.001

SOFA (per 1pt increment)

1.44

1.31–1.58

 < 0.001

–

–

–

Chronic hypertension

2.05

1.26–3.32

0.004

2.16

1.11–4.20

0.023

Diabetes

1.57

0.97–2.56

0.068

1.36

0.73–2.54

0.337

Chronic heart failure

1.21

0.50–2.95

0.674

–

–

–

CKD

1.67

0.90–3.11

0.106

1.70

0.74–3.90

0.208

Liver cirrhosis

4.31

1.41–13.18

0.01

2.01

0.50–7.89

0.325

Cancer

0.64

0.33–1.21

0.168

0.55

0.25–1.24

0.15

COPD

0.99

0.56–1.78

0.986

–

–

–

Source of infection

 Lung

0.84

0.52–1.36

0.474

–

–

–

 Abdominal

1.74

0.95–3.18

0.071

1.58

0.76–3.31

0.221

 Urinary tract

0.83

0.47–1.48

0.526

–

–

–

 Bloodstream infection

0.71

0.41–1.21

0.208

–

–

–

 Nosocomial infection

0.76

0.33–1.76

0.525

–

–

–

 Immunosuppression

1.14

0.56–2.31

0.723

–

–

–

 Cocci gram positive

0.59

0.36–0.97

0.037

0.53

0.29–0.97

0.04

 Bacillus gram negative

1.37

0.87–2.16

0.173

1.15

0.62–1.96

0.747

Organ-support at inclusion

 Epinephrine

4.77

2.31–9.83

 < 0.001

1.32

0.52–3.36

0.556

 Dobutamine

1.6

0.92–2.79

0.097

1.12

0.55–2.31

0.75

 Norepinephrine > 1 µg/kg/min at day 1

3.75

2.31–6.08

 < 0.001

0.57

0.31–1.07

0.079

 Fluid before inclusion > 1L

2.31

0.73–7.35

0.155

0.67

0.37–1.22

0.193

 Nephrotoxic drugs, yes

0.73

0.26–2.07

0.557

–

–

–

 Nephrotoxic drugs

1.09

0.91–1.33

0.336

1.02

0.80–1.30

0.871

  1. Bolditalic characters were proposed to illustrate values who reached statistical significancy, i.e. p < 0.05
  2. CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; DIC, disseminated intravascular coagulation; OR, hazard ratio; SAPS II, Simplified Acute Physiologic Score II; SOFA, Sequential Organ Failure Assessment
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