Fig. 2
From: Inhaled drug delivery: a randomized study in intubated patients with healthy lungs
Illustration of the planar acquisition to assess aerosol lung deposition with four configurations of aerosol delivery. (1) A specific circuit for aerosol therapy (SCAT group) with the inspiratory limb pre-segmented at 30 cm of a wye to place the nebulizer, a smooth inner surface and a streamlined V-shaped wye (Reference 2154019, Intersurgical Ltd, Wokingham, UK) with the HME filter removed during the nebulization. (2) A conventional circuit equipped with a heated-humidifier (RT380, Fisher & Paykel Healthcare Ltd., Auckland, New Zealand) turned off 30 min before the nebulization (HH Off group) or (3) left on during the whole procedure (HH On group), with the nebulizer at the inlet of the HH. (4) A conventional circuit (IMMED, Brussels, Belgium) with the nebulizer directly connected between the endotracheal tube and an HME filter (ETT group). ETT endotracheal tube, HH heated humidifier, SCAT specific ventilator circuit for aerosol therapy