From: Inhaled drug delivery: a randomized study in intubated patients with healthy lungs
SCAT group (n = 8) | HH Off group (n = 6) | HH On group (n = 8) | ETT group (n = 9) | |
---|---|---|---|---|
Pulmonary deposition (%) | 19.7 (14.0–24.5)*,†,‡ | 6.2 (5.4–7.3)§ | 6.9 (6.6–7.4)§ | 9.2 (8.0–13.0)§ |
Right lung | 10.6 (8.2–14.2)*,†,‡ | 3.1 (2.7–3.7)§ | 3.5 (3.0–3.9)§ | 4.7 (4.2–7.1)§ |
Inner region | 5.2 (3.6–7.8)*,†,‡ | 1.2 (1.0–1.5)§ | 1.3 (1.2–1.5)§ | 2.2 (1.7–4.4)§ |
Outer region | 5.0 (2.8–6.5)*,† | 1.8 (1.7–2.3)§ | 2.2 (1.9–2.5)§ | 2.6 (2.3–3.0) |
Penetration index | 0.44 ± 0.12 (27)*,† | 0.66 ± 0.10 (15)§ | 0.67 ± 0.07 (10)‡,§ | 0.47 ± 0.19 (40)† |
Left lung | 9.1 (6.6–10.3)*,†,‡ | 3.1 (2.6–3.7)§ | 3.5 (3.1–4.1)§ | 3.8 (3.3–4.9)§ |
Inner region | 3.9 (2.7–4.3)*,†,‡ | 1.1 (0.9–1.3)§ | 1.3 (1.2–1.4)§ | 1.4 (1.2–2.0)§ |
Outer region | 5.2 (3.6–6.3)*,†,‡ | 2.0 (1.7–2.3)§ | 2.1 (1.9–2.7)§ | 2.3 (2.0–2.9)§ |
Penetration index | 0.56 ± 0.17 (30) | 0.73 ± 0.10 (14) | 0.69 ± 0.11 (16) | 0.57 ± 0.13 (23) |
Right/left lung ratio | 1.31 ± 0.23 (17) | 1.04 ± 0.17 (16) | 1.01 ± 0.19 (19) | 1.66 ± 1.23 (74) |
Extrapulm. deposition (%) | 80.3 (75.5–86.0)*,†,‡ | 93.8 (92.7–94.6)§ | 93.1 (92.5–93.4)§ | 90.8 (87.0–92.1)§ |
ETT and Tracheal area | 23.9 (20.3–26.4)*,† | 11.9 (11.1–12.1)‡,§ | 7.4 (6.7–8.6)‡,§ | 19.2 (16.7–24.0)*,† |
Ventilator circuit | 50.5 (48.1–56.3)*,†,‡ | 78.2 (76.8–79.0)‡,§ | 81.5 (79.7–81.7)‡,§ | 65.5 (58.3–71.2)*,†,§ |
Inspiratory circuit | 38.6 ± 5.5 (14)*,†,‡ | 68.9 ± 2.9 (4)‡,§ | 73.7 ± 2.9 (4)‡,§ | 13.5 ± 5.7 (42)*,†,§ |
Inspiratory limb | 27.0 ± 9.1 (34)† | 31.2 ± 2.5 (8) | 34.7 ± 3.0 (9)§ | – |
Humidification chamber | – | 31.3 ± 3.4 (11) | 32.1 ± 5.6 (17) | – |
Nebulizer T-piece | 11.6 ± 5.0 (43) | 6.4 ± 1.4 (21)‡ | 6.9 ± 1.9 (27)‡ | 13.5 ± 5.7 (42)*,† |
Expiratory circuit | 13.1 (11.0–15.5)†,‡ | 9.1 (7.0–11.2)‡ | 6.3 (6.0–8.4)‡,§ | 52.1 (46.5–57.0)*,†,§ |
Nebulizer retention | 4.6 ± 0.11 (2) | 4.2 ± 0.09 (2) | 4.5 ± 1.3 (28) | 4.3 ± 0.13 (3) |