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Table 3 Aerosol deposition in thirty-one postoperative neurological patients

From: Inhaled drug delivery: a randomized study in intubated patients with healthy lungs

 

SCAT group (n = 8)

HH Off group (n = 6)

HH On group (n = 8)

ETT group (n = 9)

Pulmonary deposition (%)

19.7 (14.0–24.5)*,†,‡

6.2 (5.4–7.3)§

6.9 (6.6–7.4)§

9.2 (8.0–13.0)§

Right lung

10.6 (8.2–14.2)*,†,‡

3.1 (2.7–3.7)§

3.5 (3.0–3.9)§

4.7 (4.2–7.1)§

Inner region

5.2 (3.6–7.8)*,†,‡

1.2 (1.0–1.5)§

1.3 (1.2–1.5)§

2.2 (1.7–4.4)§

Outer region

5.0 (2.8–6.5)*,†

1.8 (1.7–2.3)§

2.2 (1.9–2.5)§

2.6 (2.3–3.0)

Penetration index

0.44 ± 0.12 (27)*,†

0.66 ± 0.10 (15)§

0.67 ± 0.07 (10)‡,§

0.47 ± 0.19 (40)

Left lung

9.1 (6.6–10.3)*,†,‡

3.1 (2.6–3.7)§

3.5 (3.1–4.1)§

3.8 (3.3–4.9)§

Inner region

3.9 (2.7–4.3)*,†,‡

1.1 (0.9–1.3)§

1.3 (1.2–1.4)§

1.4 (1.2–2.0)§

Outer region

5.2 (3.6–6.3)*,†,‡

2.0 (1.7–2.3)§

2.1 (1.9–2.7)§

2.3 (2.0–2.9)§

Penetration index

0.56 ± 0.17 (30)

0.73 ± 0.10 (14)

0.69 ± 0.11 (16)

0.57 ± 0.13 (23)

Right/left lung ratio

1.31 ± 0.23 (17)

1.04 ± 0.17 (16)

1.01 ± 0.19 (19)

1.66 ± 1.23 (74)

Extrapulm. deposition (%)

80.3 (75.5–86.0)*,†,‡

93.8 (92.7–94.6)§

93.1 (92.5–93.4)§

90.8 (87.0–92.1)§

ETT and Tracheal area

23.9 (20.3–26.4)*,†

11.9 (11.1–12.1)‡,§

7.4 (6.7–8.6)‡,§

19.2 (16.7–24.0)*,†

Ventilator circuit

50.5 (48.1–56.3)*,†,‡

78.2 (76.8–79.0)‡,§

81.5 (79.7–81.7)‡,§

65.5 (58.3–71.2)*,†,§

Inspiratory circuit

38.6 ± 5.5 (14)*,†,‡

68.9 ± 2.9 (4)‡,§

73.7 ± 2.9 (4)‡,§

13.5 ± 5.7 (42)*,†,§

Inspiratory limb

27.0 ± 9.1 (34)

31.2 ± 2.5 (8)

34.7 ± 3.0 (9)§

Humidification chamber

31.3 ± 3.4 (11)

32.1 ± 5.6 (17)

Nebulizer T-piece

11.6 ± 5.0 (43)

6.4 ± 1.4 (21)

6.9 ± 1.9 (27)

13.5 ± 5.7 (42)*,†

Expiratory circuit

13.1 (11.0–15.5)†,‡

9.1 (7.0–11.2)

6.3 (6.0–8.4)‡,§

52.1 (46.5–57.0)*,†,§

Nebulizer retention

4.6 ± 0.11 (2)

4.2 ± 0.09 (2)

4.5 ± 1.3 (28)

4.3 ± 0.13 (3)

  1. The penetration index was the outer to inner lung region ratio (O/I) from the 99mTc-DTPA acquisition normalized to the lung volume, i.e. divided by the O/I ratio from the 99mTc flood-field acquisition. A penetration index inferior to 1 indicated a major deposition in the inner region, mainly composed of central airways. Deposition in the expiratory circuit included the drug dose deposited in the expiratory limb and exhaled in the expiratory filter, including the heat and moisture exchanger filter in the ETT group. Data expressed as mean ± SD (coefficient of variation, %) or median (25–75% IQR) percentage of the nominal dose
  2. ETT endotracheal tube, HH heated humidifier, SCAT specific ventilator circuit for aerosol therapy
  3. * p < 0.05 vs HH Off group; p < 0.05 vs HH On group; p < 0.05 vs ETT group; §p < 0.05 vs SCAT group