Sex difference in the risk of extubation failure in ICUs

Annals of Intensive Care

Table 4 Multivariate logistic regression analysis of factors associated with reintubation within the 7 days following extubation

Variables independently associated with reintubation	Adjusted odds ratio [95% confidence interval]	P value
Variables associated with an increased risk of reintubation
Male sex (women as reference)	1.70 [1.01–2.89]	0.048
SOFA score the day of extubation—for each point increase	1.09 [1.01–1.19]	0.034
Respiratory rate before extubation—for each breath increase	1.04 [1.00–1.07]	0.048
Variables associated with a decreased risk of reintubation
Body-mass index—for each point increase	0.96 [0.92–0.99]	0.039
Cardiac arrest as main reason of admission	0.17 [0.04–0.70]	0.014
Use of prophylactic noninvasive ventilation after extubation	0.56 [0.35–0.89]	0.015

SOFA = Sequential Organ Failure Assessment
*In bold are indicated all variables independently associated with reintubation within 7 days following extubation in the final model using multivariable analysis with a p value of less than 0.05
All variables associated with reintubation with a P value < 0.10 were included in the model (R² = 0.06): (1) Male sex, (2) SOFA score the day of extubation, (3) Respiratory rate before extubation, (4) Body-mass index, (5) Cardiac arrest as main reason of admission, (6) Use of prophylactic noninvasive ventilation after extubation