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Annals of Intensive Care

Table 3 Risk factors at HFNO initiation to predict HFNO failure according to respiratory parameters (multivariate analysis)

From: ROX index performance to predict high-flow nasal oxygen outcome in Covid-19 related hypoxemic acute respiratory failure

Retained covariates known at HFNO initiation

Patients (n)

OR (95% CI)

p-value (level)

p-value (variable)

SAPS II (per additional point)

83

1.19 (1.08–1.30)

 

0.0003

PaO2 (per additional mmHg)

83

0.96 (0.92–1.00)

 

0.0497

Extension of pulmonary injuries on chest X-ray or CT

   

0.0263

  < 25%

28

Ref

  

 25–50%

28

10.32 (1.91–55.67)

0.0067

 

 50–75%

21

7.96 (1.55–41.01)

0.0131

 

  > 75%

6

9.75 (0.81–117.85)

0.0732

 
  1. Bold values depict significant statistical values
  2. HFNO high-flow nasal oxygen therapy, SAPS Simplified Acute Physiology Score, OR odds-ratio, CI confidence interval, ref  reference category for level comparisons via OR
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