Fig. 3
P:F over time by treatment group and vasopressor support level. Left graphs display the predicted P:F over time by treatment group at varying vasopressor dose levels from the longitudinal mixed-effects repeated measures models. Circle markers with solid lines display model estimates for the placebo group. Triangle markers with dashed lines, the angiotensin-II group. Colors are used to display the vasopressor dose: light blue = 0.10 mcg/kg/min; dark blue = 0.25 mcg/kg/min; purple = 0.50 mcg/kg/min; black = 0.75 mcg/kg/min. Right graphs show the model effect size for angiotensin-II treatment (purple triangles) and NED (blue squares) at each time point. Error bars indicate the 95%CIs. The model estimates for both variables are tabulated with 95%CIs and p-values at the bottom of the figure. Ang-II angiotensin-II, NED norepinephrine equivalent dose, P:F PaO2/FiO2 ratio, 95%CI 95% confidence interval, NEDTotal total vasopressor dose in NED, NEDCatechol total catecholamine dose in NED