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Annals of Intensive Care

Table 2 Respiratory measures at hour 48 for angiotensin-II versus placebo

From: Angiotensin II treatment is associated with improved oxygenation in ARDS patients with refractory vasodilatory shock

Outcome

Placebo

Angiotensin-II

 

Hour-48

∆ vs. hour-0

Hour-48

∆ vs. hour-0

Baseline-adjusted ∆

Mean (SD)

Mean (SD)

[95%CI] p-value

Mean (SD)

Mean (SD)

[95%CI] p-value

Mean [95%CI]

p-value

Oxygenation

     

 P:F (mmHg)

163.6 (73.7)

7.9 (84.2)

[− 21.5 to 37.3]

p = 0.32

265.1 (159.8)

105.9 (172.8)

[37.6 to 174.3]

p = 0.0006

98.4 [35.2 to 161.5]

p = 0.0028

 PaO2 (mmHg)

84.5 (25.8)

− 2.4 (30.4)

[− 13.0 to 8.3]

p = 0.98

118.4 (87.6)

34.9 (89.1)

[− 0.3 to 70.2]

p = 0.0322

34.4 [1.8 to 66.9]

p = 0.0392

 FiO2

0.58 (0.22)

− 0.02 (0.24)

[− 0.11 to 0.06]

p = 0.24

0.47 (0.16)

− 0.12 (0.19)

[− 0.20 to − 0.05]

p = 0.0092

− 0.10 [− 0.18 to − 0.02]

p = 0.0200

 Oxygenation Index (cmH2O/mmHg)

10.8 (7.1)

− 0.4 (8.1)

[− 3.6 to 2.7]

p = 0.26

6.2 (7.0)

− 6.0 (9.2)

[− 10.1 to − 1.9]

p = 0.0118

− 4.8 [− 8.6 to − 1.1]

p = 0.0121

Ventilation

     

 Ventilatory ratio

1.8 (0.6)

− 0.2 (0.3)

[− 0.35 to 0.02]

p = 0.42

2.0 (0.7)

− 0.1 (0.4)

[− 0.35 to 0.14]

p = 0.84

0.20 [ − 0.41 to 0.82]

p = 0.50

 PaCO2 (mmHg)

39.9 (7.8)

0.2 (8.8)

[− 2.9 to 3.3]

p = 0.51

43.1 (11.3)

− 2.0 (8.8)

[− 5.5 to 1.4]

p = 0.89

0.9 [ − 3.5 to 5.3]

p = 0.68

 pH

7.338 (0.147)

0.023 (0.136)

[− 0.020 to 0.070]

p = 0.0858

7.352 (0.099)

0.059 (0.086)

[0.020 to 0.090]

p = 0.0021

0.010 [− 0.040 to 0.070]

p = 0.63

 Respiratory rate (breaths/minute)

23.9 (7.7)

− 0.3 (6.1)

[− 2.29 to 1.71]

p = 0.91

23.3 (7.9)

− 0.2 (4.1)

[− 1.81 to 1.43]

p = 0.81

− 1.1 [− 3.8 to 1.5]

p = 0.39

 Tidal volume (mL)

425.5 (142.4)

− 2.9 (75.0)

[− 28.7 to 22.8]

p = 0.58

436.5 (151.2)

1.7 (79.7)

[− 30.4 to 33.9]

p = 0.98

16.5 [ − 26.9 to 59.9]

p = 0.45

 Minute ventilation (L/min)

10.31 (4.2)

− 0.46 (2.6)

[− 1.36 to 0.43]

p = 0.59

10.04 (2.95)

− 0.11 (2.49)

[− 1.14 to 0.92]

p = 0.69

− 0.20 [− 1.36 to 0.95]

p = 0.73

Mechanics

     

 PEEP (cmH2O)

10.6 (3.9)

− 0.1 (2.8)

[− 0.99 to 0.89]

p = 0.86

9.5 (3.5)

− 0.7 (1.9)

[− 1.46 to − 0.03]

p = 0.36

− 0.59 [− 1.61 to 0.43]

p = 0.26

 mAwP (cmH2O)

16.7 (4.2)

− 0.4 (3.8)

[− 1.90 to 1.09]

p = 0.85

16.1 (6.2)

− 1.5 (2.4)

[− 2.67 to − 0.39]

p = 0.51

− 1.35 [− 3.07 to 0.38]

p = 0.12

  1. Displays respiratory physiologic measures at hour-48 in Angiotensin-II vs. placebo. The Hour-48 columns show the average measures within the treatment group. The ∆ vs. hour-0 columns show the average difference at Hour-48 versus baseline within the treatment group, displayed as: Hour-48–Hour-0. The 95% CI and p-values in these columns reflect the results of a paired T-test. The baseline-adjusted ∆ column reflects the estimate for difference in means by for Angiotensin-II vs. Placebo groups from the linear model adjusted for the hour-0 value (primary analysis)
  2. ∆ difference, SD standard deviation, P:F PaO2/FiO2 ratio, PaO2 arterial partial pressure of oxygen, FiO2 fraction of inspired oxygen, mAwP mean airway pressure, PEEP positive end-expiratory pressure, PaCO2 arterial partial pressure of carbon dioxide
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