Fig. 2

Mechanisms of immunosenescence. Triggers of senescence induce several changes in immune cell populations, favoring the shift towards a state of impaired immune response (both innate and adaptative). This “inflammaging” includes a low intensity pro-inflammatory response, in part due to the release of immune mediators from senescent cells. All these mechanisms lead to dysregulation of the immune response and establish a positive feedback loop that perpetuates this state. Created with BioRender.com