Table 3 Odds ratios of Hospital mortality during the consecutive stages of the COVID-19 pandemic (see Additional file 1: Table S4 and Additional file 1: Table S5 for details of the fully adjusted models and missing data)
|  | 1.Wave 1 01/02/2020- 24/05/2020 Reference | 2.In-between 25/05/2020–04/10/2020 | 3.Wave 2.1 05/10/2020- 31/01/2021 | 4.Wave 2.2 01/02/2021- 24/05/2021 | 5.In-between 25/05/2021- 04/10/2021 | 6.Wave 3.1 05/10/2021- 31/01/2022 | 7.Wave 3.2 01/02/2022- 24/05/2022 | 8.In-between 25/05/2022- 04/10/2022 | 9.Endemic 05/10/2022- 31/01/2023 |
|---|---|---|---|---|---|---|---|---|---|
Total (N = 18,772) | |||||||||
1. Crude | 1.00 | 0.83 | 1.12 | 0.74 | 0.60 | 0.95 | 0.86 | 0.73 | 0.83 |
|  | [1.00–1.00] | [0.67–1.04] | [1.00–1.24] | [0.66–0.82] | [0.51–0.70] | [0.84–1.06] | [0.74–1.01] | [0.58–0.90] | [0.68–1.02] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 119.96, 8, |  < 0.001 |
2. Adjusted for age, sex | 1.00 | 0.91 | 0.99 | 0.78 | 0.83 | 1.04 | 0.75 | 0.54 | 0.55 |
BMI, and APACHE-IV risk | [1.00 – 1.00] | [0.71–1.17] | [0.88–1.11] | [0.70–0.88] | [0.70–1.00] | [0.91–1.18] | [0.63–0.89] | [0.43 – 0.69] | [0.44–0.70] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 78.95, 8, |  < 0.001 |
3. Adjusted for (…), and | 1.00 | 0.86 | 0.98 | 0.78 | 0.79 | 1.01 | 0.70 | 0.50 | 0.52 |
ICU occupancy rate | [1.00 – 1.00] | [0.67–1.11] | [0.87–1.1] | [0.69–0.88] | [0.65–0.95] | [0.88–1.16] | [0.58–0.84] | [0.39–0.65] | [0.41–0.66] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 81.97, 8, |  < 0.001 |
Restricted to those with APACHE-IV diagnosis indicative of Covid-19 as main reason for ICU admission (N = 16,187) |  |  | |||||||
|---|---|---|---|---|---|---|---|---|---|
1. Crude | 1.00 | 0.85 | 1.13 | 0.75 | 0.6 | 0.96 | 1.14 | 0.88 | 0.87 |
|  | [1.00 – 1.00] | [0.67–1.07] | [1.01–1.26] | [0.67–0.84] | [0.5–0.71] | [0.85–1.08] | [0.94–1.39] | [0.63–1.22] | [0.64–1.17] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 112.62, 8, |  < 0.001 |
2. Adjusted for age, sex | 1.00 | 0.89 | 0.99 | 0.80 | 0.86 | 1.05 | 0.86 | 0.52 | 0.51 |
BMI, and APACHE-IV risk | [1.00 – 1.00] | [0.69–1.16] | [0.88–1.12] | [0.71–0.91] | [0.71–1.04] | [0.92–1.20] | [0.69–1.07] | [0.36–0.74] | [0.37–0.71] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 51.838, 8, |  < 0.001 |
3. Adjusted for (…), and | 1.00 | 0.85 | 0.98 | 0.80 | 0.81 | 1.03 | 0.81 | 0.48 | 0.48 |
ICU occupancy rate | [1.00–1.00] | [0.65–1.11] | [0.87–1.11] | [0.71–0.91] | [0.67–0.99] | [0.89–1.18] | [0.64–1.01] | [0.33–0.69] | [0.34–0.68] |
Wald X2, df, P-value |  |  |  |  |  |  |  | 54.59, 8, |  < 0.001 |